Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1893 Results for "
Probe L
" in MedChemExpress (MCE) Product Catalog:
Products (1893)
1893 Results for "Probe L" in MCE Product Catalog:
814
312
312 Cited Publications
Cat. No.: HY-D1055
CAS No.: 1003197-00-9
Excitation/emission wavelength: 510/580 nm.
306
Research Areas:
(+)-JQ-1 (JQ1), a chemical probe, is a potent, specific, CNS-penetrant and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)) . (+)-JQ-1 also activates autophagy .
238
110
110 Cited Publications
Research Areas:
A-485, a chemical probe, is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively .
98
98 Cited Publications
Cat. No.: HY-128868
CAS No.: 60842-46-8
98
98 Cited Publications
Cat. No.: HY-128868A
CAS No.: 60842-46-8
85
85 Cited Publications
Cat. No.: HY-D0985A
CAS No.: 115532-52-0
Synonyms: Tetramethylrhodamine ethyl ester perchlorate
81
81 Cited Publications
59
59 Cited Publications
Target:
Research Areas:
BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .
45
45 Cited Publications
Cat. No.: HY-D1533
CAS No.: 1447815-38-4
42
41
41 Cited Publications
NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 μM, 0.706 μM, and 0.605 μM, respectively. NVP-2 induces cell apoptosis.
34
34 Cited Publications
32
32 Cited Publications
Target:
Research Areas:
GSK343, a chemical probe, is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.
31
31 Cited Publications
Cat. No.: HY-D1913
30
29
27
27 Cited Publications
Target:
Research Areas:
UNC0642, a chemical probe, is a potent and selective lysine methyltransferases G9a and GLP inhibitor, with an IC50 of <2.5 nM for G9a.
26
26 Cited Publications
Cat. No.: HY-D0080
CAS No.: 74515-25-6
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
