496 Results for "

bark exudates

" in MedChemExpress (MCE) Product Catalog:

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Magnolol

9 Publications Verification

Cat. No.: HY-N0163

CAS No.: 528-43-8

Category:

Cardiovascular Disease Neurological Disease Lignans Plants Magnolia officinalis. Rehd. et Wils. Phenols Polyphenols Phenylpropanoids Magnoliaceae Extract Disease Research Fields Inflammation/Immunology

Target:

RAR/RXR PPAR Autophagy Bacterial

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

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Esculetin

9 Publications Verification

Cat. No.: HY-N0284

CAS No.: 305-01-1

Category:

Fraxinus rhynchophylla Hance Coumarins Phenols Polyphenols Phenylpropanoids Plants Oleaceae Extract Disease Research Fields Inflammation/Immunology

Target:

PI3K Akt

Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities .

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Quinine

7 Cited Publications

Cat. No.: HY-D0143

CAS No.: 130-95-0

Category:

Infection Cinchona succirubra Pav. ex Klotzsch Alkaloids Quinoline Alkaloids Plants Disease Research Fields Rubiaceae Extract

Target:

Parasite Potassium Channel Dengue Virus Flavivirus

Quinine is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

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Periplocin

7 Cited Publications

Cat. No.: HY-N1381

CAS No.: 13137-64-9

Category:

Asclepiadaceae Extract Plants Periploca sepium Bunge Disease Research Fields Inflammation/Immunology Steroids

Target:

Apoptosis

Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

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Quinine dihydrochloride

7 Cited Publications

Cat. No.: HY-D0143A

CAS No.: 60-93-5

Category:

Cinchona succirubra Pav. ex Klotzsch Alkaloids Piperidine Alkaloids Plants Isoquinoline Alkaloids Rubiaceae Extract

Target:

Parasite Potassium Channel Dengue Virus Flavivirus

Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

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Quinine sulfate hydrate

7 Cited Publications

Cat. No.: HY-W010668

CAS No.: 6119-70-6

Category:

Plants

Target:

Flavivirus Dengue Virus Parasite Potassium Channel

Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

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Quinine hemisulfate hydrate

7 Cited Publications

Cat. No.: HY-D0143B

CAS No.: 207671-44-1

Category:

Infection Alkaloids Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Rubiaceae Extract

Target:

Parasite Potassium Channel Dengue Virus Flavivirus

Quinine hemisulfate hydrate is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine hemisulfate hydrate acts as a potassium channel inhibitor that suppresses the +100 mV current of MT mSlo3 (K_Ca5.1) channels induced by voltage pulses, with an IC₅₀ value of 169 μM. Quinine hemisulfate hydrate serves as a fluorescence standard reference substance with fluorescence spectrum calibration and validation activity .

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Quinine (hydrochloride)

7 Cited Publications

Cat. No.: HY-110082

CAS No.: 130-89-2

Target:

Flavivirus Dengue Virus Parasite Potassium Channel

Research Areas:

Cardiovascular Disease Infection Cancer

Quinine hydrochloride is an alkaloid extracted from cinchona bark and exhibits oral activity, acting as a potassium channel inhibitor. Quinine hydrochloride modulates the tolerance of red blood cells and presents dose-dependent toxicity and embryonic effects. Quinine hydrochloride is a typical hemolysin that directly lyses red blood cells, with cellular components of red blood cell membranes as its action targets. Quinine hydrochloride disrupts red blood cell membranes and induces hemolysis at high concentrations, while merely weakening the anti-hemolytic capacity of red blood cells at low concentrations. Quinine hydrochloride continuously reduces red blood cell tolerance after in vivo administration, and high doses can also alter blood cell counts. Quinine hydrochloride can be applied to researches related to red blood cell hemolysis, cancer and malaria .

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Toosendanin

6 Cited Publications

Cat. No.: HY-N0263

CAS No.: 58812-37-6

Category:

Triterpenes Terpenoids Melia toosendan Sieb. et Zucc. Meliaceae Extract Plants Disease Research Fields Inflammation/Immunology

Target:

Others

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

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Esculin sesquihydrate

5 Cited Publications

Cat. No.: HY-W166297

CAS No.: 66778-17-4

Target:

p38 MAPK

Research Areas:

Cancer

Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway .

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Cinchonine

5 Cited Publications

Cat. No.: HY-Y0152

CAS No.: 118-10-5

Synonyms: (8R,9S)-Cinchonine; LA40221

Category:

Alkaloids Piperidine Alkaloids Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Cancer Rubiaceae Extract

Target:

Apoptosis Parasite Autophagy Caspase Calcium Channel

Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

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Esculin

5 Cited Publications

Cat. No.: HY-N0188

CAS No.: 531-75-9

Category:

Monophenols Coumarins Phenols Phenylpropanoids Plants Other Families Extract Disease Research Fields Cancer

Target:

p38 MAPK

Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

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Fraxinellone

4 Cited Publications

Cat. No.: HY-N0242

CAS No.: 28808-62-0

Category:

Rutaceae Extract Dictamnus dasycarpus Turcz. Terpenoids Sesquiterpenes Plants Disease Research Fields Inflammation/Immunology

Target:

PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT

Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1 .

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Choerospondin

2 Cited Publications

Cat. No.: HY-N6963

CAS No.: 81202-36-0

Category:

Metabolic Disease Leguminosae Extract Choerospondias axillaris Plants Flavonoids Anacardiaceae Extract Flavonones Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch.

Target:

Others

Choerospondin is a flavanone isolated from the bark of Choerospondias axillaris .

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Lancerin

1 Cited Publications

Cat. No.: HY-N2159

CAS No.: 81991-99-3

Category:

Xanthones Polygalaceae Extract Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Polygala tenuifolia Willd.

Target:

Others

Lancerin, isolated from the root bark of Cudraniu cochinchinensis, possesses anti-lipid peroxidation .

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Isoschaftoside

1 Cited Publications

Cat. No.: HY-N1458

CAS No.: 52012-29-0

Category:

Flavones Leguminosae Extract Plants Other Families Extract Desmodium uncinatum DC. Infection Flavonoids Phenols Polyphenols Disease Research Fields Cancer

Target:

Parasite Autophagy p62 Reactive Oxygen Species (ROS)

Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit the growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study .

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Kuwanon A

1 Cited Publications

Cat. No.: HY-N2300

CAS No.: 62949-77-3

Category:

Flavones Moraceae Extract Metabolic Disease Plants Other Families Extract Flavonoids Morus alba L. Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

NO Synthase

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC₅₀ of 10.5 μM.

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A2AAR antagonist 2

1 Cited Publications

Cat. No.: HY-N12422

Category:

Natural Products Allium cepa L. Plants Liliaceae Extract

Target:

Adenosine Receptor

3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A_2AAR antagonist (IC₅₀=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research .

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Calenduloside E

1 Cited Publications

Cat. No.: HY-N6850

CAS No.: 26020-14-4

Category:

Triterpenes Terpenoids Other Diseases Aralia elata (Miq.) Seem. Plants Other Families Extract Endogenous metabolite Disease Research Fields Araliaceae Extract

Target:

Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species (ROS) PPAR

Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and Bcl-2 related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses .

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Kukoamine A

1 Cited Publications

Cat. No.: HY-N2392

CAS No.: 75288-96-9

Category:

Cardiovascular Disease Alkaloids Other Alkaloids Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:

Free Radical Scavengers Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX

Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE₂, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .

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