325 Results for "

division

" in MedChemExpress (MCE) Product Catalog:
Products (325)

325 Results for "division" in MCE Product Catalog:

346
346 Publications Verification
Cat. No.: HY-15886
CAS No.: 338967-87-6
Purity:  99.96%
Synonyms: Mitochondrial division inhibitor 1
Research Areas:  

Cancer

Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.
loading...
    loading...
119
119 Cited Publications
Cat. No.: HY-D0938
CAS No.: 150347-59-4
Synonyms: CFSE; 5(6)-Carboxyfluorescein diacetate succinimidyl ester; 5(6)-CFDA N-succinmidyl ester
CFDA-SE is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus . CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells .
loading...
    loading...
80
80 Cited Publications
Cat. No.: HY-14519B
CAS No.: 133073-73-1
Purity:  98.41%
Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate
Methotrexate hydrate is a substance that affects cell growth and division. It is commonly used to fight certain diseases, especially cancer and autoimmune diseases. It works by inhibiting the process by which cells synthesize DNA.
loading...
    loading...
29
29 Cited Publications
Cat. No.: HY-N7452
CAS No.: 4434-05-3
Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.
loading...
    loading...
17
17 Cited Publications
Cat. No.: HY-N6733
CAS No.: 38966-21-1
Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .
loading...
    loading...
14
14 Cited Publications
Cat. No.: HY-18062
CAS No.: 58-14-0
Synonyms: Pirimecidan; Pirimetamin; RP 4753
Target:  

Antifolate Parasite

Research Areas:  

Infection Cancer

Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .
loading...
    loading...
13
13 Cited Publications
Cat. No.: HY-100888
CAS No.: 1330782-76-7
Purity:  99.94%
Synonyms: TAK-931
Target:  

CDK

Research Areas:  

Cancer

Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM. Simurosertib has anti-cancer activity .
loading...
    loading...
12
12 Cited Publications
Cat. No.: HY-12054
CAS No.: 422513-13-1
Purity:  98.89%
Research Areas:  

Cancer

Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral .
loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-N0160
CAS No.: 525-79-1
Synonyms: 6-Furfuryladenine; N6-Furfuryladenine
Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects .
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-12454
CAS No.: 796073-69-3
Purity:  99.64%
Synonyms: Ravtansine
Research Areas:  

Cancer

DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-17563
CAS No.: 961-07-9
Synonyms: Deoxyguanosine; Guanine deoxyriboside
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells .
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-126542
CAS No.: 2378855-09-3
Purity:  99.47%
Target:  

VRK

Research Areas:  

Neurological Disease

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-124306
CAS No.: 496775-95-2
Purity:  99.75%
Synonyms: CID-888706
Target:  

Ras

Research Areas:  

Cancer

ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-B0941
CAS No.: 1214-39-7
Synonyms: Benzyladenine; 6-BAP; N6-Benzyladenine
6-Benzylaminopurine (Benzyladenine) is a cytokinin that causes plant growth and development by stimulating cell division and inhibiting respiratory kinases, thereby prolonging the preservation of green vegetables .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-111548
CAS No.: 2351882-11-4
Purity:  98.61%
Target:  

Microtubule/Tubulin

Research Areas:  

Others

Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-N5034
CAS No.: 1071-23-4
Synonyms: Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine
Phosphorylethanolamine (Monoaminoethyl phosphate) is a membrane phospholipid and an important precursor of Phosphatidylcholine (HY-B2233B). It is found in most animal tissues and various human extracranial tumors, playing a critical role in membrane integrity, cell division, mitochondrial respiratory function, and more. Studies have shown that changes in the abundance of Phosphorylethanolamine are associated with Alzheimer's disease and Parkinson's disease. Lowering the ratio of Phosphorylethanolamine to Phosphatidylcholine in the liver can improve insulin signaling. Phosphorylethanolamine holds promise for research in the fields of cancer, neurodegenerative disorders, and metabolic diseases .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-19700
CAS No.: 1637-39-4
trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P9980
CAS No.: 2061894-48-0
Synonyms: GSK2857914

Research Areas:  

Cancer

Belantamab (GSK2857916) is a humanized IgG1 anti-BCMA/TNFRSF17 monoclonal antibody. Belantamab is linked to MMAF (HY-15579) through a non-cleavable ADC linker to synthesize the antibody-active molecule conjugate (ADC) Belantamab mafodotin (HY-P3239). After binding to BCMA on the surface of tumor cells, Belantamab mafodotin enters the cell through receptor-mediated endocytosis. After entering the cell, Belantamab mafodotin releases MMAF, blocks cell division by inhibiting tubulin polymerization, arrests the cell cycle and induces cell apoptosis. Belantamab can be used for the study of multiple myeloma, especially relapsed/refractory multiple myeloma .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-118208
CAS No.: 743456-83-9
Purity:  99.90%
Synonyms: CID-2160985
Target:  

Ras

Research Areas:  

Cancer

ML-097 (CID-2160985) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7 .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P80611
Synonyms: CDK1; CDC2; CDC28A; CDKN1; P34CDC2; Cyclin-dependent kinase 1; CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase

Host:  

Rabbit

Application:  

WB, IP

Reactivity:  

Human

loading...
    loading...