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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
261 Results for "
membrane function
" in MedChemExpress (MCE) Product Catalog:
Products (261)
261 Results for "membrane function" in MCE Product Catalog:
186
186 Publications Verification
Target:
Mitochondrial Metabolism PINK1/Parkin NOD-like Receptor (NLR) Autophagy Calcium Channel Apoptosis
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
MitoTEMPO hydrate is a mitochondria-targeted antioxidant . MitoTEMPO hydrate induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. MitoTEMPO hydrate regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. MitoTEMPO hydrate reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. MitoTEMPO hydrate can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
186
186 Publications Verification
Target:
Calcium Channel PINK1/Parkin Mitochondrial Metabolism Apoptosis Autophagy NOD-like Receptor (NLR)
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
184
184 Cited Publications
Art. -Nr.: HY-D0814
CAS. Nr.: 28718-90-3
Synonyms: 4',6-Diamidino-2-phenylindole dihydrochloride
184
184 Cited Publications
Art. -Nr.: HY-D2868
CAS. Nr.: 47165-04-8
Synonyms: 4',6-Diamidino-2-phenylindole
178
178 Cited Publications
Art. -Nr.: HY-D1738
CAS. Nr.: 28718-91-4
Synonyms: 4',6-Diamidino-2-phenylindole dilactate
95
95
95 Cited Publications
Art. -Nr.: HY-N0322A
Target:
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)
71
71 Cited Publications
Synonyms: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B
42
42 Cited Publications
Art. -Nr.: HY-D0989
CAS. Nr.: 145037-81-6
28
20
20 Cited Publications
Art. -Nr.: HY-W127378
CAS. Nr.: 144189-73-1
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .
16
16 Cited Publications
Art. -Nr.: HY-16657
CAS. Nr.: 163847-77-6
Target:
Forschungsgebiete:
TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions .
14
Cholesterol (synthetic) is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol (synthetic) plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol (synthetic) is also an endogenous estrogen-related receptor α (ERRα) agonist .
14
10
10 Cited Publications
Art. -Nr.: HY-N0570
CAS. Nr.: 10597-60-1
Synonyms: DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol
8
8
8 Cited Publications
Art. -Nr.: HY-15930A
CAS. Nr.: 64285-73-0
Synonyms: BM blue dihydrochloride; Sure Blue TMB dihydrochloride
8
8 Cited Publications
Art. -Nr.: HY-15930B
CAS. Nr.: 207738-08-7
Synonyms: Sure Blue TMB dihydrochloride x.hydrate
8
8 Cited Publications
Art. -Nr.: HY-15930C
CAS. Nr.: 54827-18-8
Synonyms: BM blue monosulfate; Sure Blue TMB monosulfate
6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
