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By Targets:	5-HT Receptor (8) Acyltransferase (1) ADC Payload (1) Adenosine Receptor (1) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Adrenergic Receptor (9) Akt (1) Amyloid-β (1) Angiotensin Receptor (1) Antibiotic (5) Apoptosis (22) Arrestin (1) Autophagy (3) Bacterial (16) Bcl-2 Family (4) BCL6 (4) BCRP (1) Biochemical Assay Reagents (19) c-Kit (1) c-Met/HGFR (1) Cadherin (2) Calcium Channel (2) Carbonic Anhydrase (3) Caspase (5) CD47 (1) CDK (4) Cholinesterase (ChE) (2) COX (10) Cytochrome P450 (2) Dengue Virus (1) Deubiquitinase (1) DNA Alkylator/Crosslinker (2) DNA Stain (3) DNA/RNA Synthesis (6) Dopamine Receptor (7) Drug Derivative (2) Drug Intermediate (2) Drug Isomer (1) Drug Metabolite (11) DYRK (2) E1/E2/E3 Enzyme (3) EGFR (1) Endogenous Metabolite (29) Enterovirus (1) Environmental Pollutants (9) Epigenetic Reader Domain (1) ERK (2) Estrogen Receptor/ERR (14) Eukaryotic Initiation Factor (eIF) (1) Factor Xa (1) FAK (1) Fatty Acid Synthase (FASN) (1) Flavivirus (1) FLT3 (2) Fluorescent Dye (47) Fungal (3) GABA Receptor (1) Glycosyltransferase (1) HCV (1) HCV Protease (1) Herbicide (2) Histamine Receptor (4) Histone Methyltransferase (1) HIV (4) IFNAR (1) iGluR (2) IKK (2) IKZF Family (1) Influenza Virus (1) Integrin (3) Interleukin Related (9) IRAK (1) Isotope-Labeled Compounds (12) JAK (1) Keap1-Nrf2 (1) Lipase (2) Liposome (4) Lipoxygenase (1) LPL Receptor (1) LRRK2 (2) LXR (1) MDM-2/p53 (2) mGluR (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Molecular Glues (2) Monoamine Oxidase (2) Mps1 (1) nAChR (1) NAMPT (1) NF-κB (3) NKCC (3) NO Synthase (1) Opioid Receptor (1) Orphan GPCR (1) P-glycoprotein (4) Parasite (7) PDGFR (1) PDK-1 (2) PERK (1) Phospholipase (1) PI3K (1) Potassium Channel (3) PPAR (2) Prostaglandin Receptor (1) PROTACs (2) Quinone Reductase (1) Radionuclide-Drug Conjugates (RDCs) (1) Ras (1) Reactive Oxygen Species (ROS) (4) Reference Standards (16) RET (3) ROR (1) Ser/Thr Protease (1) Sodium Channel (1) Somatostatin Receptor (3) STAT (4) STK33 (3) Taste Receptor (1) Tau Protein (1) TGF-β Receptor (3) TNF Receptor (2) TNK1 (2) Topoisomerase (1) TRP Channel (1) UGT (1) VEGFR (1)
By Research Areas:	Cancer (68) Cardiovascular Disease (25) Endocrinology (9) Infection (31) Inflammation/Immunology (35) Metabolic Disease (37) Neurological Disease (39)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Emulsifiers (2) Solubilizing Agents (1) Cholesterol (2)

257

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W090090

BODIPY 493/503 Maximum Cited Publications 104 Publications Verification Pyrromethene 546	Fluorescent Dye	Others
BODIPY493/503 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .

HY-N2333

Resiniferatoxin 5+ Cited Publications (+)-Resiniferatoxin	TRP Channel	Cardiovascular Disease Cancer
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .

HY-116705

2-Deoxy-2-fluoro-L-fucose 1 Publications Verification	Glycosyltransferase	Cancer
2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma .

HY-P99029

Magrolimab 3 Publications Verification Hu5F9-G4	CD47	Cancer
Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab, an IgG4 isotype, lacks ADCC function and exhibits relatively weak ADCP effector function. Magrolimab can be used for the study of malignant bone tumors and breast cancer .

HY-D1237

BODIPY 505/515 2 Publications Verification	Fluorescent Dye	Metabolic Disease
BODIPY505/515 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 505/515 nm .

HY-D1614

BODIPY 493/503 methyl bromide 15+ Cited Publications	Fluorescent Dye	Others
BODIPY493/503 methyl bromide is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .

HY-D1106

Py-BODIPY-NHS ester	Fluorescent Dye	Cancer
BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions . Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells .

HY-138226

BODIPY 558/568 C12 4 Publications Verification	Fluorescent Dye	Others
BODIPY 558/568 C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 558/568 nm .

HY-101836

DKM 2-93 5 Publications Verification	E1/E2/E3 Enzyme	Cancer
DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC₅₀ of 430 μM.

HY-10791

Ritanserin 3 Publications Verification R 55667	5-HT Receptor Histamine Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT₂ receptor, with an IC₅₀ of 0.9 nM, less active on Histamine H₁, Dopamine D₂, Adrenergic α₁, Adrenergic α₂ receptors .

HY-112780

UC2288 5+ Cited Publications	MDM-2/p53 Apoptosis	Cancer
UC2288 is a potent and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 potently inhibits cancer cell growth by inducing apoptosis. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM .

HY-D0846

Diethyl pyrocarbonate	Biochemical Assay Reagents	Neurological Disease
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .

HY-DY1004

BODIPY 493/503 (solution)	Fluorescent Dye	Others
BODIPY 493/503 (solution) is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm. Solvent and concentration: DMSO: 5 mM.

HY-D1570

BODIPY FL C12	Fluorescent Dye	Others
BODIPYFL C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 480/508 nm .

HY-D1617

BODIPY 500/510 C1, C12 2 Publications Verification	Fluorescent Dye	Others
BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 500/510 nm . Protect from light, stored at -20°C.

HY-135731

4-Methylamino antipyrine	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-D1610

BODIPY FL C5	Fluorescent Dye	Others
BODIPY FL C₅ is a green fluorescent fatty acid. BODIPY FL C₅ can be used as a precursor for the synthesis of various fluorescent phospholipids. BODIPY FL C₅ is relatively insensitive to the environment and fluoresces in both water-soluble and lipid environments .

HY-101011

Naloxonazine dihydrochloride	Opioid Receptor	Infection Neurological Disease
Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC₅₀ of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity .

HY-121276

Benperidol 1 Publications Verification	Dopamine Receptor	Neurological Disease
Benperidol is a relatively old antipsychotic agent. Benperidol is a butyrophenone antipsychotic, with the highest neuroleptic potency in terms of D2 receptor blockade .

HY-113008A

cis-Urocanic acid (Z)-Urocanic acid; cis-UCA	5-HT Receptor	Inflammation/Immunology
cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (K_d=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor .

HY-100024

NTRC 0066-0	Mps1	Cancer
NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC₅₀=0.9 nM). NTRC 0066-0 can be used for the research of cancer .

HY-DY1061

BODIPY 558/568 C12 (solution)	Fluorescent Dye	Others
BODIPY 558/568 C12 (solution) is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 558/568 nm . Solvent and concentration: DMSO: 2 mM

HY-119816

Piretanide	NKCC	Cardiovascular Disease
Piretanide is an oral active, relatively safe and effective diuretic. Piretanide has the potential for the research of congestive heart failure with a potential advantage of having potassium-sparing properties. Piretanide can also be used for the research of hypertension ^[1] ^[2].

HY-D2083

BODIPY 540 (purity 99%) 1 Publications Verification	Fluorescent Dye	Metabolic Disease
BODIPY 540 (purity>98%) is a BODIPY dye.BODIPY dye is a small molecule dye with strong UV absorption ability.Its fluorescence peak is relatively sharp, its quantum yield is high, and it is relatively insensitive to the polarity and pH value of the environment.BODIPY 540 (purity>98%) has a purity higher than 98% and is suitable for cell experiments (Ex/Em = 540/580 nm) .

HY-N8194

Syringetin-3-O-glucoside Syringetin 3-O-β-D-glucoside	Others	Neurological Disease
Syringetin-3-O-glucosid (Syringetin 3-O-β-D-glucoside), a flavonol glycoside, shows relatively weak DPPH and ABTS radical scavenging activity .

HY-N16617

Platycodin V	Lipase	Metabolic Disease
Platycodin V is a triterpenoid saponin. Platycodin V has a relatively weak inhibitory effect on pancreatic lipase.

HY-N2102

Tenacissoside I	Others	Cancer
Tenacissoside I is a C21 steroid from the Marsdenia tenacissima, which is detected at relatively high level in M. tenacissima .

HY-W001536

7-Methoxyindole, 98%	Biochemical Assay Reagents Fluorescent Dye	Others
7-Methoxyindole, 98% is a Fluorescent emitter. 7-Methoxyindole, 98% exhibits a relatively blue excitation spectrum .\n

HY-126031A

(S)-KT109	Endogenous Metabolite	Others
(S)-KT109 is an inhibitor of diacylglycerol lipase β (DAGLβ) with low inhibitory activity (IC50 = 39.81 nM). (S)-KT109 has relatively low inhibitory activity against DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM). (S)-KT109 also has relatively low inhibitory activity against α/β-amidase domain-containing 6 (ABHD6) (IC50 = 630.9 nM) .

HY-N6737

Aureothricin	Bacterial Antibiotic	Infection
Aureothricin is a dithiolopyrrolone (DTP) antibiotic first isolated from Streptomyces and exhibits relatively broad-spectrum antibiotic activity. Aureothricin can inhibit adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin .

HY-15904

N-Ethyl-N-(3-sulfopropyl)-m-anisidine sodium ESPA	Biochemical Assay Reagents	Others
N-Ethyl-N-(3-sulfopropyl)-m-anisidine sodium (ESPA) is a Trinder's reagent and a highly water-soluble aniline derivative. N-Ethyl-N-(3-sulfopropyl)-m-anisidine sodium has a relatively high absorption wavelength at 540 nm and can be widely used in diagnostic tests and biochemical experiments .

HY-118332

19(R)-HETE	Prostaglandin Receptor	Cardiovascular Disease
19(R)-HETE is a vasodilator in renal arteries, whereas 19(S)-HETE was relatively inactive .

HY-139114

20-Carboxyarachidonic acid	PPAR	Metabolic Disease
20-Carboxyarachidonic acid, a relatively stable metabolite of 20-HETE, is an endogenous dual activator of PPARalpha and PPARgamma .

HY-109571

HZ-1157	Flavivirus Dengue Virus HCV Protease	Infection Inflammation/Immunology
HZ-1157 inhibits HCV NS3/4A protease with an IC₅₀ of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC₅₀ = 0.15 μM) and is a relatively nontoxic (CC₅₀ > 10 μM) dengue antiviral agent .

HY-135731A

4-Methylamino antipyrine hydrochloride	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-119392

16-Hexadecanolide	Biochemical Assay Reagents	Others
16-Hexadecanolide is a lactone that is commonly used in ring-opening polymerization reactions and can be catalyzed by enzymes to form polymers at a relatively high polymerization rate .

HY-D0144

Resorufin methyl ether Methoxyresorufin	Cytochrome P450	Others
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate . Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents .

HY-D1768

Fluo-4FF AM	Fluorescent Dye	Others
Fluo-4FF AM is a cell-permeant fluorescent calcium indicator. Fluo-4FF is an analog of Fluo-4 with a lower affinity for calcium, which is suitable for investigation of relatively high level of intracellular calcium.

HY-W110781

Basic Blue 20	DNA Stain	Others
Basic Blue 20 is a very convenient red-emitting DNA stains. Basic Blue 20 has relatively narrow excitation and emission spectra, with peaks at 633 and 677 nm, respectively. Basic Blue 20 also has a very high resistance to photobleaching .

HY-W142446S

2,6-Dichlorobenzamide-3,4,5-d3	Isotope-Labeled Compounds Environmental Pollutants Herbicide	Others
2,6-Dichlorobenzamide-3,4,5-d₃ is the deuterium labeled 2,6-Dichlorobenzamide (HY-W142446). 2,6-Dichlorobenzamide is a herbicide degradation product that is relatively difficult to degrade .

HY-110257

BDY FL-X, SE	Fluorescent Dye	Others
BODIPY FL-X,SE is a fluorescent greendye for the labeling of amine, shows a high fluorescence quantum yield and is relatively insensitive to pH change. BODIPY FL-X,SE can be used as an alternative for FAM, Cy2 or FITC. λ_abs: 504 nm; λ_em:510 nm .

HY-161096

Antitumor agent-127	ROR	Cancer
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines .

HY-157920

Biotin-PE-maleimide N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine	Biochemical Assay Reagents	Others
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .

HY-W127739

Zineb Zinc ethylene-1, 2-bisdithiocarbamate	Environmental Pollutants Biochemical Assay Reagents	Others
Zineb is an agricultural fungicide of the dithiocarbamate class. Its toxicity is relatively low, and there is little evidence of human harm from exposure. Oxidative stress is one of the main factors contributing to diseases caused by Zineb. Zineb does not alter the activity of any superoxide dismutase enzymes. Catalase (CAT) activity was reduced only by Zineb.

HY-N5060R

Estragole (Standard) 4-Allylanisole (Standard)	Parasite Reference Standards	Neurological Disease
Estragole (Standard) is the analytical standard of Estragole. This product is intended for research and analytical applications. Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .

HY-144366

P-gp inhibitor 3	P-glycoprotein	Cancer
P-gp inhibitor 3 is an effective P-glycoprotein (P-gp) inhibitor. P-gp inhibitor 3 inhibits the efflux function of P-gp by activating P-gp ATPase. P-gp inhibitor 3 has relatively stronger multidrug resistance (MDR) reversal ability and enhances the anti-tumor activity of Paclitaxel .

HY-176885

CDD-2211	STK33 RET	Others
CDD-2211 is a STK33 inhibitor, with a K_d of 0.018 nM and an IC₅₀ of 5 nM. CDD-2211 has relatively weak inhibitory effects on off-target kinases, with IC₅₀ values of 115 nM for CLK1, 48 nM for CLK2, 187 nM for CLK4, and 78 nM for RET. CDD-2211 can be used for the study of contraception .

HY-176885A

CDD-2212	STK33 RET	Others
CDD-2212 is a STK33 inhibitor, with a K_d of 1.9 nM and an IC₅₀ of 999 nM. CDD-2212 has relatively weak inhibitory effects on off-target kinases, with IC₅₀ values of 3223 nM for CLK1, 1555 nM for CLK2, 5884 nM for CLK4, and 1093 nM for RET. CDD-2212 can be used for the study of contraception .

HY-167082

AY 31906	NKCC Potassium Channel Sodium Channel	Cardiovascular Disease
AY 31906 is an orally active pyrimidine sulfonamide diuretic. AY 31906 exhibits potent diuretic and natriuretic activities in rats and dogs, along with relatively potassium-sparing properties. AY 31906 exhibits superior activity to Furosemide (HY-B0135). AY-31906 also has antihypertensive effects and can be used in the research of cardiovascular diseases .

HY-125463

ANQ9040	nAChR	Neurological Disease
ANQ9040 is a steroidal relaxant. ANQ9040 is a relatively low-affinity and non-depolarizing nicotinic antagonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0322

Cholesterol (from animal) Maximum Cited Publications 85 Publications Verification	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Environmental Pollutants Endogenous Metabolite Estrogen Receptor/ERR Bacterial Liposome
Cholesterol (from animal) is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol (from animal) plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol (from animal) is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N2333

Resiniferatoxin 5+ Cited Publications (+)-Resiniferatoxin	Cardiovascular Disease Structural Classification Euphorbia resinifera O. Berg Monophenols Classification of Application Fields Phenols Euphorbiaceae Plants Disease Research Fields Source Classification	TRP Channel
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .

HY-16950A

(E/Z)-4-Hydroxytamoxifen 3 Publications Verification Afimoxifene; 4-OHT	Alkaloids Monophenols Classification of Application Fields Other Alkaloids Phenols Endogenous metabolite Disease Research Fields Source Classification Cancer	Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

HY-N2334

Glycochenodeoxycholic acid 5 Publications Verification Chenodeoxycholylglycine	Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-N0322A

Cholesterol (Water Soluble) Maximum Cited Publications 85 Publications Verification	Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Liposome
Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells . (Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)

HY-N2334A

Glycochenodeoxycholic acid sodium salt 5 Publications Verification Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-16940

24(S)-Hydroxycholesterol 24S-OHC; 24S-HC; Cerebrosterol	Classification of Application Fields Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids Source Classification	LXR iGluR Endogenous Metabolite
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators .

HY-N0322R

Cholesterol (Standard) 70+ Cited Publications	Classification of Application Fields Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Liposome Reference Standards Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol (Standard) is the analytical standard of Cholesterol. This product is intended for research and analytical applications. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N5060

Estragole 4-Allylanisole	Structural Classification Pandanus amaryllifolius Roxb. Simple Phenylpropanols Phenylpropanoids Plants Pandanaceae Source Classification	Environmental Pollutants Parasite Apoptosis Keap1-Nrf2 NF-κB
Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular ROS production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity .

HY-N8194

Syringetin-3-O-glucoside Syringetin 3-O-β-D-glucoside	Flavonols Flavonoids Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Source Classification	Others
Syringetin-3-O-glucosid (Syringetin 3-O-β-D-glucoside), a flavonol glycoside, shows relatively weak DPPH and ABTS radical scavenging activity .

HY-N2334R

Glycochenodeoxycholic acid (Standard) Chenodeoxycholylglycine (Standard)	Structural Classification Microorganisms Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid (Standard) is the analytical standard of Glycochenodeoxycholic acid. This product is intended for research and analytical applications. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC)[1][2][3][4].

HY-N2334AR

Glycochenodeoxycholic acid sodium salt (Standard) Chenodeoxycholylglycine sodium salt (Standard); Sodium glycochenodeoxycholate (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-N16617

Platycodin V	Triterpenes Structural Classification Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Source Classification	Lipase
Platycodin V is a triterpenoid saponin. Platycodin V has a relatively weak inhibitory effect on pancreatic lipase.

HY-N2102

Tenacissoside I	other families Classification of Application Fields Plants Disease Research Fields Steroids Cancer Source Classification	Others
Tenacissoside I is a C21 steroid from the Marsdenia tenacissima, which is detected at relatively high level in M. tenacissima .

HY-N6737

Aureothricin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Aureothricin is a dithiolopyrrolone (DTP) antibiotic first isolated from Streptomyces and exhibits relatively broad-spectrum antibiotic activity. Aureothricin can inhibit adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin .

HY-139114

20-Carboxyarachidonic acid	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	PPAR
20-Carboxyarachidonic acid, a relatively stable metabolite of 20-HETE, is an endogenous dual activator of PPARalpha and PPARgamma .

HY-N5060R

Estragole (Standard) 4-Allylanisole (Standard)	Structural Classification Pandanus amaryllifolius Roxb. Simple Phenylpropanols Phenylpropanoids Plants Pandanaceae Source Classification	Parasite Reference Standards
Estragole (Standard) is the analytical standard of Estragole. This product is intended for research and analytical applications. Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .

HY-33914

4-Hydroxymethylpyrazole	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876) produced through hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole demonstrates inhibitory effects on alcohol dehydrogenase (ADH) in both humans and monkeys, but its inhibition constant is significantly higher than that of Fomepizole, rendering its in vivo impact negligible .

HY-117845

Citreamicin alpha LL-E19085α	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Citreamicin alpha (LL-E 19085-alpha) is an antibiotic whose in vitro antimicrobial activity against 429 clinical isolates of Gram-positive cocci has been tested by the agar dilution method. These microorganisms included 313 strains of Staphylococci and 116 strains of Streptococci. The in vitro activity of Citreamicin alpha was compared with that of ampicillin, amoxicillin, ceftriaxone, erythromycin, and vancomycin. For Staphylococci, the MIC values of Citreamicin alpha ranged from 0.12-4.0 μg/ml, and for Streptococcus pyogenes of the genus Streptococcus, it was 0.03-0.12 μg/ml. However, enterococci were relatively resistant, requiring 2.0 μg/ml of the agent to inhibit 64% of the 62 tested strains. The in vitro activity of this antibiotic was much better than that of ampicillin, amoxicillin, ceftriaxone, and erythromycin, but comparable or slightly inferior to that of vancomycin.

HY-16950AR

(E/Z)-4-Hydroxytamoxifen (Standard) Afimoxifene (Standard); 4-OHT (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Phenols Endogenous metabolite Source Classification	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite
(E/Z)-4-Hydroxytamoxifen (Standard) is the analytical standard of (E/Z)-4-Hydroxytamoxifen. This product is intended for research and analytical applications. (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

HY-W780198

Endophenazine A	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Fungal
Endophenazine A has activity against Gram-positive bacteria and filamentous fungi such as mucor and Penicillium. Its weeding ability to Lemna minor is relatively low .

HY-136293

Mechercharmycin A	Natural Products Microorganisms Classification of Application Fields Marine natural products Disease Research Fields Marine microorganism Cancer Source Classification	Apoptosis
Mechercharmycin A is a cytotoxic substance isolated from marine-derived Thermoactinomyces sp. YM3-251. Mechercharmycin A exhibits relatively strong antitumor activity .

HY-N3602

Cleroindicin F (-)-Rengyolone	Natural Products Classification of Application Fields Tecoma stans Plants Bignoniaceae Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
Cleroindicin F ((-)-Rengyolone), a cleroindicin, is an antimicrobial agent. Cleroindicin F shows relatively high anticandidal activity against Candida strains with a MIC value down to 12.5 µg/mL .

HY-N14207

Cytosporin C	Natural Products Microorganisms Source Classification	Angiotensin Receptor
Cytosporin C is a hexahydrobenzopyran derivative and an angiotensin II receptor inhibitor. Cytosporin C has relatively strong inhibitory activity against AT₂, with an IC₅₀ of 30-40 μM .

HY-B1453R

(±)-Carnitine chloride (Standard) DL-Carnitine chloride (Standard); DL-Levocarnitine chloride (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	Reference Standards Reactive Oxygen Species (ROS)
Benoxaprofen (Standard) is the analytical standard of Benoxaprofen. This product is intended for research and analytical applications. Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation .

HY-N3497

Isochamaejasmin	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Other Flavonoids	NF-κB DNA/RNA Synthesis Parasite Apoptosis
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum) and relatively* low cytotoxicity (CC₅₀ of 29.0 μM) .

HY-N13115A

Protoescigenin 21-tiglate (E)-21-Angeloyl-protoaescigenin	Aesculus chinensis Bunge Triterpenes Terpenoids Hippocastanaceae Plants Source Classification	Others
Protoescigenin 21-tiglate (compound 10) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. However, the antitumor activity of Protoescigenin 21-tiglate is relatively weak, with IC50 values of >80 μM and 80 μM against MCF-7 and HeLa cells, respectively .

HY-152120

(±)-Aiphanol Aiphanol	Phenols Polyphenols Arecaceae Plants Aiphanes aculeata Willd Source Classification	COX VEGFR
(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of COX-1 and COX-2. The inhibitory effect on COX-1 (IC₅₀ = 1.9 μM) is particularly strong, while the effect on COX-2 (IC₅₀= 9.9 μM) is relatively weak .(±)-Aiphanol effectively inhibits VEGFR2 (IC₅₀=0.92 μM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active .

HY-N16328

Cyanine 7.5 maleimide chloride	Structural Classification Lipid	Fluorescent Dye
Cy7.5 maleimide chloride is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .

HY-N15791

Cyanine 3.5 maleimide chloride	Structural Classification Lipid	Fluorescent Dye
Cyanine3.5 maleimide chloride is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .

HY-N9229

Myricadenin A	Structural Classification Natural Products Other Phenylpropanoids Phenylpropanoids Plants Morella adenophora (Hance) J. Herb. Source Classification Myricaceae	NO Synthase Bacterial
Myricadenin A is an iNOS inhibitor, capable of effectively inhibiting the production of NO (EC₅₀ = 18.1 μM). Myricadenin A has moderate ABTS free radical scavenging activity (SC₅₀ = 175.4 μM) and relatively weak anti-tuberculosis activity (MIC = 80.0 μg/mL). Myricadenin A can be used in inflammation-related research .

HY-33914R

4-Hydroxymethylpyrazole (Standard)	Natural Products Endogenous metabolite Source Classification	Drug Metabolite Reference Standards
4-Hydroxymethylpyrazole (Standard) is an analytical standard for 4-Hydroxymethylpyrazole (HY-33914). This product is intended for research and analytical applications. 4-Hydroxymethylpyrazole is the primary metabolite of fomepizole (HY-B0876) via hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole inhibits alcohol dehydrogenase (ADH) in humans and monkeys, but the inhibition constant is much higher than that of fomepizole and is therefore negligible in vivo

HY-N17737

Floramanoside F	Malvaceae Structural Classification Flavonols Flavonoids Abelmoschus manihot (Linn.) Medicus Plants Source Classification	Fatty Acid Synthase (FASN) Cytochrome P450
Floramanoside F is a type of flavonol glycoside compound. Floramanoside F has a moderate free radical scavenging effect, with a SC₅₀ value of 25.1 μM. Floramanoside F has a relatively weak inhibitory activity on aldose reductase, with a IC₅₀ value greater than 100 μM. Floramanoside F has strong binding affinity with key target enzymes of type 1 diabetic nephropathy (T1DN) (Fasn, Cyp2e1, Cyp4a32), and can inhibit lipid accumulation and oxidative stress, thereby alleviating renal inflammation and fibrosis. Floramanoside F can be used to study type 1 diabetic nephropathy and diabetic complications .

Cat. No.	Product Name	Chemical Structure

HY-N0322S

Cholesterol-d7

Cholesterol-d₇ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S5

Cholesterol-13C2

Cholesterol- ¹³C₂ is the ¹³C labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S1

Cholesterol-d6

Cholesterol-d₆ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S2

Cholesterol-d6-1

Cholesterol-d₆-1 is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S4

Cholesterol-13C3

1 Publications Verification

Cholesterol- ¹³C₃ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S6

Cholesterol-d4

1 Publications Verification

Cholesterol-d₄ is deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S7

Cholesterol-d1

Cholesterol-d1 is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N5060S

Estragole-d4

Estragole-d₄ is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular ROS production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity [10] .

HY-N0322S3

Cholesterol-13C5

Cholesterol- ¹³C₅ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-W142446S

2,6-Dichlorobenzamide-3,4,5-d3
2,6-Dichlorobenzamide-3,4,5-d₃ is the deuterium labeled 2,6-Dichlorobenzamide (HY-W142446). 2,6-Dichlorobenzamide is a herbicide degradation product that is relatively difficult to degrade .

HY-135731AS

4-Methylamino antipyrine-d3 hydrochloride

4-Methylamino antipyrine-d₃ (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-N0322S8

Cholesterol-18O

Cholesterol- ¹⁸O is the ¹⁸O-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-12715S

Yohimbine-13C,d3 1 Publications Verification
Yohimbine- ¹³C,d₃ is the ¹³C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.

HY-113008AS

cis-Urocanic acid-13C3
cis-Urocanic acid- ¹³C₃ is the ¹³C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor .

HY-12383S

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

HY-15746S

(rac)-Dobutamine-d4 hydrochloride
(rac)-Dobutamine-d₄ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-15746S1

(rac)-Dobutamine-d6 hydrochloride
(rac)-Dobutamine-d₆ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-119816S

Piretanide-d4
Piretanide-d₄ is the deuterium labeled Piretanide. Piretanide is an oral active, relatively safe and effective diuretic. Piretanide has the potential for the research of congestive heart failure with a potential advantage of having potassium-sparing properties. Piretanide can also be used for the research of hypertension[1][2].

HY-W701503

4-Methylamino antipyrine-d3-1

4-Methylamino antipyrine-d₃-1 is the deuterium labeled 4-Methylamino antipyrine-1. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0322GL

Cholesterol (GMP Like)	Liposome Estrogen Receptor/ERR Endogenous Metabolite	Metabolic Disease Cancer
Cholesterol (GMP Like) is Cholesterol (HY-N0322) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

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