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Results for "

rooting agent

" in MedChemExpress (MCE) Product Catalog:

44

Inhibitors & Agonists

7

Biochemical Assay Reagents

24

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1964
    Gibberellic acid
    1 Publications Verification

    Gibberellin A3

    		 Environmental Pollutants Drug Derivative Metabolic Disease
    Gibberellic acid (GA3) is a natural plant growth regulator with oral bioactivity. Gibberellic acid governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid can be used in studies of plant growth, metabolism, and abiotic stress responses .
    Gibberellic acid
  • HY-109061
    Lazertinib
    3 Publications Verification

    YH25448; GNS-1480

    		 Apoptosis Akt TRP Channel EGFR ERK Infection Neurological Disease Metabolic Disease Cancer
    Lazertinib (YH25448; GNS-1480) is an orally active, blood-brain barrier permeable third-generation EGFR tyrosine kinase inhibitor, as well as an ABCB1/ABCG2 inhibitor and a TRPA1 activator. Lazertinib exhibits IC50 values of 0.4 mM and 0.2 mM against human ABCB1 and ABCG2, respectively. By inhibiting mutant EGFR signaling, EGFR phosphorylation and the downstream ERK/AKT pathway, as well as upregulating surface expression of EGFR/MET, Lazertinib induces cell cycle arrest, apoptosis, spontaneous calcium responses, hyperexcitability of dorsal root ganglion (DRG) neurons, and TRPA1-dependent pain-like behaviors. Lazertinib competitively binds to the substrate-binding sites of ABCB1/ABCG2, stimulates their ATPase activity without altering their expression or plasma membrane localization, thereby enhancing ADCC activity, acting as a chemosensitizer, and reversing ABCB1-mediated multidrug resistance. It exerts antitumor activity as a single agent or in combination with other drugs. Lazertinib is applicable to research related to non-small cell lung cancer, multidrug-resistant cancers, and paresthesia .
    Lazertinib
  • HY-N6973
    Boldine
    1 Publications Verification

    		 RANKL/RANK Apoptosis Inflammation/Immunology Cancer
    Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research .
    Boldine
  • HY-N0186
    Indole-3-butyric acid
    1 Publications Verification

    Indolebutyric acid

    		 Environmental Pollutants Endogenous Metabolite Others
    Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process .
    Indole-3-butyric acid
  • HY-N0834
    Pulsatilla saponin D
    1 Publications Verification

    SB365; Hederacolchiside A

    		 Apoptosis Cancer
    Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla chinensis, is an anti-tumor agent .
    Pulsatilla saponin D
  • HY-W116336D
    Zinc oxide, <100 nm particle size

    		Biochemical Assay Reagents Fungal Bacterial Infection Cancer
    Zinc oxide, <100 nm particle size is a nitrate reductase modulator and growth promoter with plant stress resistance activity and oral toxicity. Zinc oxide, <100 nm particle size acts as a nutrient source for maize plants. By enhancing nitrate reductase activity and reducing free proline levels, it significantly improves plant height, root length and dry matter weight of maize, and its growth-promoting effect is comparable to that of traditional zinc sulfate fertilizer. Zinc oxide, <100 nm particle size induces anemia-related and persistent tissue inflammatory damage, leading to obvious histopathological adverse reactions in the stomach, pancreas, eyes and prostate of rats. Zinc oxide, <100 nm particle size acts as a non-toxic antibacterial agent and selective cytotoxin against multiple bacteria, fungi and spores .
    Zinc oxide, <100 nm particle size
  • HY-107339
    Deserpidine

    Harmonyl

    		 Angiotensin-converting Enzyme (ACE) Cardiovascular Disease Neurological Disease Metabolic Disease
    Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex .
    Deserpidine
  • HY-N0331
    Ziyuglycoside I
    1 Publications Verification

    		 MDM-2/p53 Apoptosis Cancer
    Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .
    Ziyuglycoside I
  • HY-109061B
    Lazertinib mesylate
    3 Publications Verification

    YH25448 mesylate; GNS-1480 mesylate

    		 TRP Channel EGFR Akt ERK Apoptosis Cancer
    Lazertinib (YH25448; GNS-1480) mesylate is an orally active, blood-brain barrier permeable third-generation EGFR tyrosine kinase inhibitor, as well as an ABCB1/ABCG2 inhibitor and a TRPA1 activator. Lazertinib mesylate exhibits IC50 values of 0.4 mM and 0.2 mM against human ABCB1 and ABCG2, respectively. By inhibiting mutant EGFR signaling, EGFR phosphorylation and the downstream ERK/AKT pathway, as well as upregulating surface expression of EGFR/MET, Lazertinib mesylate induces cell cycle arrest, apoptosis, spontaneous calcium responses, hyperexcitability of dorsal root ganglion (DRG) neurons, and TRPA1-dependent pain-like behaviors. Lazertinib mesylate competitively binds to the substrate-binding sites of ABCB1/ABCG2, stimulates their ATPase activity without altering their expression or plasma membrane localization, thereby enhancing ADCC activity, acting as a chemosensitizer, and reversing ABCB1-mediated multidrug resistance. It exerts antitumor activity as a single agent or in combination with other drugs. Lazertinib mesylate is applicable to research related to non-small cell lung cancer, multidrug-resistant cancers, and paresthesia .
    Lazertinib mesylate
  • HY-N8022
    Lucidin primeveroside

    Lucidin 3-O-β-primeveroside

    		 Biochemical Assay Reagents Cancer
    Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts .
    Lucidin primeveroside
  • HY-W250721C
    Carbomer 941

    CBM 941

    		 Biochemical Assay Reagents
    Carbomer 941 (CBM 941) is an acrylic acid polymer, which can be used as a thickening agent. Carbomer 941 provides a stable gel matrix, exhibits good heat, light and microbial contamination resistance. Carbomer 941 facilitates the drug release and local application, which can be used in the pharmaceutical industry .
    Carbomer 941
  • HY-N0186A
    Indole-3-butyric acid potassium
    1 Publications Verification

    Indolebutyric acid potassium

    		 Endogenous Metabolite Others
    Indole-3-butyric acid (Indolebutyric acid) potassium is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid potassium is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process .
    Indole-3-butyric acid potassium
  • HY-N0186R
    Indole-3-butyric acid (Standard)

    Indolebutyric acid (Standard)

    		 Reference Standards Endogenous Metabolite Others
    Indole-3-butyric acid (Standard) is the analytical standard of Indole-3-butyric acid. This product is intended for research and analytical applications. Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process .
    Indole-3-butyric acid (Standard)
  • HY-W778225
    Vanillic acid-13C6

    		Isotope-Labeled Compounds Infection
    Vanillic acid- 13C6 is the 13C labeled isotope of Vanillic acid- 13C6(HY-N0708 ).Vanillic acid is a flavoring agent found in edible plants and fruits, and in the root of angelica. Vanillic acid inhibits NF-κB activation. It has anti-inflammatory and antimicrobial activities.
    Vanillic acid-13C6
  • HY-N7659A
    Glucobrassicin potassium

    		Phytohormone Microtubule/Tubulin Apoptosis Others
    Glucobrassicin potassium is an indole-based anticancer agent and plant growth-regulating hormone. Glucobrassicin potassium exerts its biological activity by disrupting the integrity of microtubule networks in both plant and mammalian cells. At high concentrations, Glucobrassicin potassium inhibits seed germination and root growth; it can also specifically induce apoptosis in mammalian cancer cells and interfere with the intercellular transmission of viruses that rely on microtubules. In plants, Glucobrassicin potassium can be catalyzed by myrosinase to release growth-regulating substances, exhibiting a concentration-dependent growth-regulating effect .
    Glucobrassicin potassium
  • HY-N7659
    Glucobrassicin

    		Phytohormone Apoptosis Microtubule/Tubulin Cancer
    Glucobrassicin is an indole-based anticancer agent and plant growth-regulating hormone. Glucobrassicin exerts its biological activity by disrupting the integrity of microtubule networks in both plant and mammalian cells. At high concentrations, Glucobrassicin inhibits seed germination and root growth; it can also specifically induce apoptosis in mammalian cancer cells and interfere with the intercellular transmission of viruses that rely on microtubules. In plants, Glucobrassicin can be catalyzed by myrosinase to release growth-regulating substances, exhibiting a concentration-dependent growth-regulating effect .
    Glucobrassicin
  • HY-N0186B
    Indole-3-butyric acid,suitable for plant cell culture

    IBA

    		 Biochemical Assay Reagents Others
    Indole-3-butyric acid,suitable for plant cell culture (IBA) is a plant auxin and a good rooting agent. Indole-3-butyric acid,suitable for plant cell culture can promote rooting of herbaceous and woody ornamental plants and is used to increase fruiting rate. Indole-3-butyric acid is an auxin precursor that is converted into indole 3-acetic acid (IAA) during peroxisomal β-oxidation. Indole-3-butyric acid,suitable for plant cell culture can be used for cell culture .
    Indole-3-butyric acid,suitable for plant cell culture
  • HY-163311
    Transketolase-IN-6

    		Transketolase Herbicide Others
    Transketolase-IN-6 is a potent transketolase inhibitor and a herbicide. Transketolase-IN-6 inhibits root growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis. Transketolase-IN-6 shows low phytotoxicity to wheat, maize, soybean, and cotton. Transketolase-IN-6 can be used for the research of herbicidal agent development .
    Transketolase-IN-6
  • HY-N6973R
    Boldine (Standard)
    1 Publications Verification

    		 Reference Standards RANKL/RANK Inflammation/Immunology
    Boldine (Standard) is the analytical standard of Boldine. This product is intended for research and analytical applications. Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis .
    Boldine (Standard)
  • HY-N1964A
    Gibberellic acid, suitable for plant cell culture

    		Drug Derivative Metabolic Disease
    Gibberellic acid, suitable for plant cell culture (GA3, suitable for plant cell culture) is a natural plant growth regulator with oral bioactivity. Gibberellic acid, suitable for plant cell culture governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid, suitable for plant cell culture optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid, suitable for plant cell culture mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid, suitable for plant cell culture can be used in studies of plant growth, metabolism, and abiotic stress responses .
    Gibberellic acid, suitable for plant cell culture
  • HY-175736
    Herbicidal agent 11

    		Herbicide Others
    Herbicidal agent 11 (Compound 8a) is a herbicidal agent. Herbicidal agent 11 has significant postemergence herbicidal activities against the monocotyledonous weed Echinochloa crusgalli with inhibition of potent root and stem growth and has a good crop selectivity against wheat, maize, and oilseed rape. Herbicidal agent 11 also has effective inhibitory effects on Digitaria sanguinalis, Eclipta prostrate and Eleusine indica. Herbicidal agent 11 can be used for the development of herbicides .
    Herbicidal agent 11
  • HY-135243
    Ypenyl

    		DNA/RNA Synthesis Cancer
    Ypenyl is a cytostatic. Ypenyl hydrochloride, belonging to the alkylating agent class, exhibits clear genotoxicity and cell cycle disruption properties. Ypenyl induces chromosomal aberrations in broad bean root tip meristem cells and leads to a decrease in the mitotic index. Ypenyl may be used in cancer research .
    Ypenyl
  • HY-N1964R
    Gibberellic acid (Standard)

    Gibberellin A3 (Standard)

    		 Reference Standards Drug Derivative Metabolic Disease
    Gibberellic acid (Standard) is the analytical standard of Gibberellic acid (GA3) (HY-N1964). This product is intended for research and analytical applications. Gibberellic acidis a natural plant growth regulator with oral bioactivity. Gibberellic acid governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid can be used in studies of plant growth, metabolism, and abiotic stress responses .
    Gibberellic acid (Standard)
  • HY-128498
    Anticancer agent 182

    		Others Cancer
    Anticancer agent 182 (Compound 1) is a cytotoxic flavonoid compound isolated from the root ofMuntingia colabura L. Anticancer agent 182 exhibits anticancer activity .
    Anticancer agent 182
  • HY-156778
    Antitumor agent-120

    		Drug Derivative Cancer
    Antitumor agent-120 (compound 1) is a flavonoid compound isolated from Kudzu root.Antitumor agent-120 has no significant inhibitory activity against LNCaP and PC3 cancer cells, with IC50s >50 μM .
    Antitumor agent-120
  • HY-133800
    Volvaltrate B

    		Biochemical Assay Reagents Cancer
    Volvaltrate B is an anticancer agent, iridoid, can be obtained from the root of valerian (Valeriana officinalis). Volvaltrate B is effective against ovarian tumors in female mice. Volvaltrate B has the potential to study cancer .
    Volvaltrate B
  • HY-N2021AR
    Phosphoramidon Disodium (Standard)

    		Reference Standards MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology Cancer
    Indole-3-butyric acid (Standard) is the analytical standard of Indole-3-butyric acid. This product is intended for research and analytical applications. Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process .
    Phosphoramidon Disodium (Standard)
  • HY-N4322R
    Decursinol angelate (Standard)

    		Reference Standards PKC Inflammation/Immunology Cancer
    Decursinol angelate (Standard) is the analytical standard of Decursinol angelate. This product is intended for research and analytical applications. Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities .
    Decursinol angelate (Standard)
  • HY-167735
    Salvizol

    Bisdequalinium diacetate

    		 Bacterial Infection
    Salvizol (Bisdequalinium diacetate) is a chemotherapeutic agent with a broad spectrum of bactericidal activity, effective in the apical third of root canals. Salvizol possesses the ability to dissolve organic dentin matrix, facilitating mineralization and tubule exposure. Salvizol maintains a neutral pH, ensuring biological compatibility while exhibiting significant cleansing potency.
    Salvizol
  • HY-107339R
    Deserpidine (Standard)

    Harmonyl (Standard)

    		 Reference Standards Angiotensin-converting Enzyme (ACE) Neurological Disease Metabolic Disease
    Deserpidine (Standard) is the analytical standard of Deserpidine. This product is intended for research and analytical applications. Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex .
    Deserpidine (Standard)
  • HY-N0331R
    Ziyuglycoside I (Standard)

    		Reference Standards MDM-2/p53 Apoptosis Cancer
    Ziyuglycoside I (Standard) is the analytical standard of Ziyuglycoside I. This product is intended for research and analytical applications. Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .
    Ziyuglycoside I (Standard)
  • HY-N15426
    Herbicidal agent 9

    		Herbicide Others
    Herbicidal Agent 9 (Compound 5) is a herbicidal derivative of 23-spirocholestane. In combination with Compound 6, Herbicidal Agent 9 inhibits Arabidopsis root growth, exhibiting an EC50 of 6.89 μM .
    Herbicidal agent 9
  • HY-170401
    Antibacterial agent 260

    		Bacterial Herbicide Infection
    Antibacterial agent 260 (Compound 4r) exhibits board-spectrum antibacterial activity, inhibits P. aeruginosa and S. aureus with MIC of 0.0076 μM. Antibacterial agent 260 acts as a herbicidal agent, that inhibits the root- and stem-growth of Raphanus sativus L. (radish seed) .
    Antibacterial agent 260
  • HY-N17359
    Mulberrofuran W

    		Drug Derivative Cancer
    Mulberrofuran W is a 2-arylbenzofuran with a farnesyl group that exists in the root bark of Morus mongolica. It also acts as a cytotoxic agent with low cytotoxicity and weak tumor specificity .
    Mulberrofuran W
  • HY-182568
    Iocarmic acid

    		Biochemical Assay Reagents Neurological Disease
    Iocarmic acid is a myelographic contrast agent. Iocarmic acid is used for lumbar nerve root angiography and ventriculography. Iocarmic acid induces arachnoiditis via lumbar subarachnoid injection. Iocarmic acid can be used for the research of arachnoiditis .
    Iocarmic acid
  • HY-N19220
    Radiclonic acid

    		Bacterial Endogenous Metabolite Antibiotic Infection Cancer
    Radiclonic acid acts as an antibacterial agent, anticancer agent, and root growth promoter. Radiclonic acid is isolable from fungi of the genus Penicillium. Radiclonic acid exhibits antibacterial activity against MRSA with a MIC of 3.13 μg/mL. Radiclonic acid shows anticancer activity against esophageal cancer, bladder cancer, and liver cancer. Radiclonic acid promotes root growth in Chinese cabbage seedlings. Radiclonic acid is inactive against pancreatic cancer and cervical cancer. Radiclonic acid can be used in research related to Staphylococcus aureus infection, bladder cancer, esophageal cancer, and liver cancer .
    Radiclonic acid
  • HY-122145
    Ypenyl hydrochloride

    		DNA/RNA Synthesis Cancer
    Ypenyl hydrochloride is a cytostatic. Ypenyl hydrochloride, belonging to the alkylating agent class, exhibits clear genotoxicity and cell cycle disruption properties. Ypenyl hydrochloride induces chromosomal aberrations in broad bean root tip meristem cells and leads to a decrease in the mitotic index. Ypenyl hydrochloride may be used in cancer research .
    Ypenyl hydrochloride
  • HY-N0186S3
    Indole-3-butyric acid-d2

    Indolebutyric acid-d2

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    Indole-3-butyric acid-d2 (Indolebutyric acid-d2) is the deuterium labeled Indole-3-butyric acid (HY-N0186). Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process .
    Indole-3-butyric acid-d2
  • HY-N13282
    Glyceocarpin

    		Bacterial Fungal Infection
    Glyceocarpin is a phytoalexin and antibacterial agent naturally occurring in Glycine max, with weak antifungal activity. Glyceocarpin serves as the biosynthetic precursor of Glyceollins II (HY-N18032) and Glyceollins III. Glyceocarpin can be biosynthesized by the prenyltransferase and subsequent modification by cytochrome P450 enzymes. Glyceocarpin can be used for the study of soybean root and stem rot caused by Phytophthora sojae .
    Glyceocarpin
  • HY-N18182
    Mudanpioside E

    		Glycosidase Inflammation/Immunology
    Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC50 of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases .
    Mudanpioside E
  • HY-N20619
    Sterekunthal B

    		Parasite Cardiovascular Disease Infection
    Sterekunthal B is a naphthoquinone compound and antimalarial agent. Sterekunthal B can be isolated from plants of the Bignoniaceae family, including the root bark of Stereospermum colais. Sterekunthal B inhibits the growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum strain PoW with an IC50 of 23.3 μg/mL. Sterekunthal B also inhibits the growth of Chloroquine-resistant Plasmodium falciparum strain Dd2 with an IC50 of 15.2 μg/mL. Sterekunthal B exhibits non-selective cytotoxicity toward endothelial cells. Sterekunthal B can be used in malaria-related research .
    Sterekunthal B
  • HY-N18080
    Parthenin

    		Parasite DNA Alkylator/Crosslinker Bacterial Infection Inflammation/Immunology Cancer
    Parthenin is a pseudoguaianolide-type sesquiterpene lactone present in Parthenium hysterophorus L. Parthenin induces chromosomal aberrations, mainly chromatid breaks, in human peripheral blood lymphocytes. Parthenin exhibits toxicity against Salmonella typhimurium and Escherichia coli strains, with reduced toxicity in the presence of a metabolic activation system (S9). Parthenin acts as an antifeedant against the 6th instar larvae of the tobacco cutworm (Spodoptera litura). Parthenin shows insecticidal activity against adult cowpea weevils (Callosobruchus maculatus). Parthenin inhibits seed germination and seedling growth of sicklepod (Cassia tora). Parthenin possesses nematicidal activity against the 2nd instar larvae of the southern root-knot nematode (Meloidogyne incognita). Parthenin serves as a research agent for studies related to cancer, malaria, amoebiasis, inflammatory diseases, and bacterial infections .
    Parthenin
  • HY-N1964B
    Gibberellic acid Sterile Solution (1 mg/ml)

    GA3 Sterile Solution (1 mg/ml)

    		 Drug Derivative Metabolic Disease
    Gibberellic acid Sterile Solution (1 mg/mL) (GA3 Sterile Solution (1 mg/mL)) is a natural plant growth regulator with oral bioactivity. Gibberellic acid Sterile Solution (1 mg/mL) governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid Sterile Solution (1 mg/mL) optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid Sterile Solution (1 mg/mL) mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid Sterile Solution (1 mg/mL) can be used in studies of plant growth, metabolism, and abiotic stress responses .
    Gibberellic acid Sterile Solution (1 mg/ml)
  • HY-109061A
    Lazertinib mesylate hydrate

    YH25448 mesylate hydrate; GNS-1480 mesylate hydrate

    		 Apoptosis Akt TRP Channel EGFR ERK Cancer
    Lazertinib (YH25448; GNS-1480) mesylate hydrate is an orally active, blood-brain barrier permeable third-generation EGFR tyrosine kinase inhibitor, as well as an ABCB1/ABCG2 inhibitor and a TRPA1 activator. Lazertinib mesylate hydrate exhibits IC50 values of 0.4 mM and 0.2 mM against human ABCB1 and ABCG2, respectively. By inhibiting mutant EGFR signaling, EGFR phosphorylation and the downstream ERK/AKT pathway, as well as upregulating surface expression of EGFR/MET, Lazertinib mesylate hydrate induces cell cycle arrest, apoptosis, spontaneous calcium responses, hyperexcitability of dorsal root ganglion (DRG) neurons, and TRPA1-dependent pain-like behaviors. Lazertinib mesylate hydrate competitively binds to the substrate-binding sites of ABCB1/ABCG2, stimulates their ATPase activity without altering their expression or plasma membrane localization, thereby enhancing ADCC activity, acting as a chemosensitizer, and reversing ABCB1-mediated multidrug resistance. It exerts antitumor activity as a single agent or in combination with other drugs. Lazertinib mesylate hydrate is applicable to research related to non-small cell lung cancer, multidrug-resistant cancers, and paresthesia .
    Lazertinib mesylate hydrate

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