SGC6870
Based on 1 publication(s) in Google Scholar
SGC6870, a chemical probe, is a potent, selective and cytoactive allosteric inhibitor of PRMT6 with IC50 of 77 nM.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 2561471-27-8
- Formula: C23H21BrN2O2S
- Molecular Weight:469.39
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SGC6870
MoreAll Histone Methyltransferase Isoforms
More
Biological Activity
IC50: 77 nM (PRMT6)[1].
Chemical Information
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CAS No. 2561471-27-8
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Appearance Solid
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Molecular Weight 469.39
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Formula C23H21BrN2O2S
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Color White to off-white
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SMILES
O=C1CN(C(C2=CC=C(Br)S2)=O)[C@H](C3=CC(C)=CC(C)=C3)C4=CC(C)=CC=C4N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Transl Med
2025 Jan 16;23(1):74. PMID: 39819457
Solvent & Solubility
DMSO : ≥ 100 mg/mL (213.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1304 mL | 10.6521 mL | 21.3042 mL | 53.2606 mL |
| 5 mM | 0.4261 mL | 2.1304 mL | 4.2608 mL | 10.6521 mL | |
| 10 mM | 0.2130 mL | 1.0652 mL | 2.1304 mL | 5.3261 mL | |
| 15 mM | 0.1420 mL | 0.7101 mL | 1.4203 mL | 3.5507 mL | |
| 20 mM | 0.1065 mL | 0.5326 mL | 1.0652 mL | 2.6630 mL | |
| 25 mM | 0.0852 mL | 0.4261 mL | 0.8522 mL | 2.1304 mL | |
| 30 mM | 0.0710 mL | 0.3551 mL | 0.7101 mL | 1.7754 mL | |
| 40 mM | 0.0533 mL | 0.2663 mL | 0.5326 mL | 1.3315 mL | |
| 50 mM | 0.0426 mL | 0.2130 mL | 0.4261 mL | 1.0652 mL | |
| 60 mM | 0.0355 mL | 0.1775 mL | 0.3551 mL | 0.8877 mL | |
| 80 mM | 0.0266 mL | 0.1332 mL | 0.2663 mL | 0.6658 mL | |
| 100 mM | 0.0213 mL | 0.1065 mL | 0.2130 mL | 0.5326 mL |
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