2. Epigenetics
  3. Epigenetic Reader Domain
  4. UMB298

UMB298 

Cat. No.: HY-139148 Purity: 99.11%
COA Handling Instructions

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor.

For research use only. We do not sell to patients.

UMB298 Chemical Structure

UMB298 Chemical Structure

CAS No. : 2266569-73-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 369 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 369 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1].

IC50 & Target[1]

BRD4

5193 nM (IC50)

In Vitro

UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1].
UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1].
UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MOLM13 and MM cells
Concentration: 0.01~10 μM
Incubation Time: 50 days
Result: Inhibited cells growth.

Western Blot Analysis[1]

Cell Line: MOLM13 cells
Concentration: 1~10 μM
Incubation Time: 2 hours
Result: Reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia.

RT-PCR[1]

Cell Line: MOLM13 cells
Concentration: 3 μM
Incubation Time: 2 hours
Result: Down-regulated MYC expression.
Molecular Weight

479.01

Appearance

Solid

Formula

C27H31ClN4O2
CAS No.
SMILES

CC1=C(C2=CC3=NC(CCC4=CC=C(OC)C(Cl)=C4)=C(NC5CCCCC5)N3C=C2)C(C)=NO1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (52.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0876 mL 10.4382 mL 20.8764 mL
5 mM 0.4175 mL 2.0876 mL 4.1753 mL
10 mM 0.2088 mL 1.0438 mL 2.0876 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

UMB2982266569-73-5UMB 298UMB-298Epigenetic Reader DomainpotentselectiveMOLM13MMbromodomainCBP30Inhibitorinhibitorinhibit

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