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Cat. No.: HY-118394

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β-Hydroxymethyl chalcone

β-Hydroxymethyl chalcone is a time-dependent selective HDAC2 inhibitor, with IC₅₀ values of 0.17 μM (24 h) and 9.19 μM (1 h). After binding to the catalytic zinc ion in the active pocket of HDAC2, β-Hydroxymethyl chalcone undergoes an intramolecular nucleophilic attack to form a cyclic product, resulting in time-dependent tight binding. β-Hydroxymethyl chalcone can be used for the study of HDAC2 selective inhibition and related epigenetic targets^[1].

For research use only. We do not sell to patients.

CAS No.: 1613310-15-8
Formula: C₁₆H₁₄O₂
Molecular Weight:238.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

β-Hydroxymethyl chalcone Chemical Structure

CAS No.: 1613310-15-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

hHDAC2

0.17 μM (IC₅₀, 24 h)

hHDAC2

9.19 μM (IC₅₀, 1 h)

hHDAC1

2.74 μM (IC₅₀, 24 h)

hHDAC1

3.68 μM (IC₅₀, 1 h)

hHDAC3

~ 50 μM (IC₅₀, 1h, 24 h)

All HDAC Isoforms :

In Vitro

β-Hydroxymethyl chalcone (1-24 h) exhibits time-dependent selective inhibition of HDAC2 in in vitro recombinant enzymatic assays. The IC₅₀ values after 1 h and 24 h of incubation are 9.19 μM and 0.17 μM, respectively, with an approximately 20-fold selectivity for HDAC2 over HDAC1 (3.68 μM at 1 h; 2.74 μM at 24 h), and shows weak activity against HDAC3 (approximately 50 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1613310-15-8
Molecular Weight 238.28
Formula C₁₆H₁₄O₂
SMILES

O=C(C1=CC=CC=C1)/C=C(C2=CC=CC=C2)\CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou J, et al. Computational design of a time-dependent histone deacetylase 2 selective inhibitor. ACS chemical biology. 2015 Mar 20;10(3):687-92.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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