α-Linolenic acid sodium
Based on 13 publication(s) in Google Scholar
α-Linolenic acid sodium (ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3) is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid sodium can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid sodium possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.
For research use only. We do not sell to patients.
- Purity : 96.66%
- CAS No.: 822-18-4
- Formula: C18H29NaO2
- Molecular Weight:300.41
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) α-Linolenic acid sodium
More- Nat Commun. 2024 Sep 27;15(1):8273. [Abstract]
- Exp Mol Med. 2026 May;58(5):1642-1656. [Abstract]
- J Adv Res. 2025 Apr:70:339-353. [Abstract]
- Redox Biol. 2023 Oct:66:102857. [Abstract]
- Adv Sci (Weinh). 2025 Aug;12(32):e00058. [Abstract]
- Phytomedicine. 2025 Nov:147:157214. [Abstract]
- J Ethnopharmacol. 2025 May 28:348:119891. [Abstract]
- Food Biosci. 2025 Jul.
- Eur J Pharmacol. 2023 Apr 15:945:175618. [Abstract]
- Molecules. 2023 Apr 11;28(8):3375. [Abstract]
- ACS Pharmacol Transl Sci. 2025 Oct 4;8(11):4095-4106. [Abstract]
- Bulletin of Medical Sciences. 2026;99(2):125-146.
- bioRxiv. 2025 Jun 16.
Customer Validation & Images
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Histological Imaging/Staining
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In Vivo Efficacy Study
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Bio/Physico-chemical Assay
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RT-PCR
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Cell Proliferation/Viability Assay
Biological Activity
Description
In Vitro
α-Linolenic acid sodium converses into the longer chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
α-Linolenic acid (35-175 mg/kg; i.v., for 10 days) sodium suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g)[1].
α-Linolenic acid (70-175 mg/kg; i.v., for 10 days) sodium inhibits collagen stimulated platelet aggregation in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice
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Dosage:50, 100, 250 mg/kg
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Administration:i.v., 10 days
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Result:Inhibited collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 822-18-4
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Appearance Solid
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Molecular Weight 300.41
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Formula C18H29NaO2
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Color White to light yellow
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SMILES
CC/C=C\C/C=C\C/C=C\CCCCCCCC(O[Na])=O
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Synonyms
ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Nat Commun
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice. [Abstract]2024 Sep 27;15(1):8273. PMID: 39333556 -
Exp Mol Med
Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation. [Abstract]2026 May;58(5):1642-1656. PMID: 42120478 -
J Adv Res
Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging. [Abstract]2025 Apr:70:339-353. PMID: 38718895
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Apr:70:339-353. [Abstract]
VIMTIN / K14, CD31 and FLT4 immunostaining shows angiogenesis after ALA (200 μM; s.c.) treatment in young mice; Statistics of CD31+ cells and FLT4+ cells. Scale bars, 50 μm.
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Redox Biol
Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury. [Abstract]2023 Oct:66:102857. PMID: 37611494
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Oct:66:102857. [Abstract]
Percentage of dead FHs74Int cells, treated with indicated PUFAs (20 or 40 μM) or/and Fer-1 (5 μM), detected at 120 h after irradiation. αLA: α-Linolenic acid (40 μM); LA: Linoleic acid; DHA: Docosahexaenoic acid; AA: Arachidonic acid.
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Adv Sci (Weinh)
Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar-Modified Arabidopsis. [Abstract]2025 Aug;12(32):e00058. PMID: 40470697 -
Phytomedicine
Alpha-linolenic acid ameliorates T2DM via reshaping gut-liver axis and inflammatory GPR120-NF-κB/NLRP3 pathway in mouse and rat models. [Abstract]2025 Nov:147:157214. PMID: 40929881
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov:147:157214. [Abstract]
α-Linolenic acid (ALA, 500 mg/kg; Oral gavage; Once daily for 8 weeks) treatment effectively reduced weight gain starting at week 4.
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov:147:157214. [Abstract]
α-Linolenic acid (ALA, 500 mg/kg; Oral gavage; Once daily for 8 weeks) significantly inhibited the increase of FBG in mice starting from week 6.
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov:147:157214. [Abstract]
The mRNA expression levels of inflammatory cytokines (TNF-α, IL-6, IL-17A, IFN-γ, IL-10, IL-1β and IL-18) in the liver of db/db mice were quantified by qRT-PCR. The results showed that, compared with the CO group, a significant decrease in liver TNF-α, IL-6, IL-17A, interferon-γ (IFN-γ), IL-1β, and IL-18 levels was observed in theα-Linolenic acid (ALA, 500 mg/kg; Oral gavage; Once daily for 8 weeks)-treated group.
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J Ethnopharmacol
Xihuang pill suppressed primary liver cancer growth by downregulation of AFP and YAP signaling. [Abstract]2025 May 28:348:119891. PMID: 40294663 -
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Eur J Pharmacol
Polyunsaturated fatty acids drive neutrophil extracellular trap formation in nonalcoholic steatohepatitis. [Abstract]2023 Apr 15:945:175618. PMID: 36841284 -
Molecules
Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]2023 Apr 11;28(8):3375. PMID: 37110608 -
ACS Pharmacol Transl Sci
Ultrasensitive Profiling of Arachidonic Acid Metabolites Based on 5‑(Diisopropylamino)amylamine Derivatization-Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. [Abstract]2025 Oct 4;8(11):4095-4106. PMID: 41262585 -
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Protocols
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Purity & Documentation
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Data Sheet (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Linolenic acid sodium Related Classifications
HY-N0728A Related Classifications
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