α-Linolenic acid sodium
Based on 12 publication(s) in Google Scholar
α-Linolenic acid sodium (ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3) is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid sodium can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid sodium possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.
For research use only. We do not sell to patients.
- Purity: 96.66%
- CAS No.: 822-18-4
- Formula: C18H29NaO2
- Molecular Weight:300.41
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications Citing Use of MedChemExpress (MCE) α-Linolenic acid sodium
More- Nat Commun. 2024 Sep 27;15(1):8273. [Abstract]
- Exp Mol Med. 2026 May;58(5):1642-1656. [Abstract]
- J Adv Res. 2025 Apr:70:339-353. [Abstract]
- Redox Biol. 2023 Oct:66:102857. [Abstract]
- Adv Sci (Weinh). 2025 Aug;12(32):e00058. [Abstract]
- Phytomedicine. 2025 Nov:147:157214. [Abstract]
- J Ethnopharmacol. 2025 May 28:348:119891. [Abstract]
- Food Biosci. 2025 Jul.
- Eur J Pharmacol. 2023 Apr 15:945:175618. [Abstract]
- Molecules. 2023 Apr 11;28(8):3375. [Abstract]
- ACS Pharmacol Transl Sci. 2025 Oct 4;8(11):4095-4106. [Abstract]
- bioRxiv. 2025 Jun 16.
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Histological Imaging/Staining
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In Vivo Efficacy Study
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Bio/Physico-chemical Assay
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RT-PCR
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Cell Proliferation/Viability Assay
Biological Activity
α-Linolenic acid sodium converses into the longer chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
α-Linolenic acid (35-175 mg/kg; i.v., for 10 days) sodium suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g)[1].
α-Linolenic acid (70-175 mg/kg; i.v., for 10 days) sodium inhibits collagen stimulated platelet aggregation in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice
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Dosage:50, 100, 250 mg/kg
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Administration:i.v., 10 days
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Result:Inhibited collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 822-18-4
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Appearance Solid
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Molecular Weight 300.41
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Formula C18H29NaO2
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Color White to light yellow
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SMILES
CC/C=C\C/C=C\C/C=C\CCCCCCCC(O[Na])=O
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Synonyms
ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (12)
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Journal Impact Factor
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Most Recent
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Nat Commun
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice. [Abstract]2024 Sep 27;15(1):8273. PMID: 39333556 -
Exp Mol Med
Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation. [Abstract]2026 May;58(5):1642-1656. PMID: 42120478 -
J Adv Res
Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging. [Abstract]2025 Apr:70:339-353. PMID: 38718895
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Apr:70:339-353. [Abstract]
VIMTIN / K14, CD31 and FLT4 immunostaining shows angiogenesis after ALA (200 μM; s.c.) treatment in young mice; Statistics of CD31+ cells and FLT4+ cells. Scale bars, 50 μm.
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Redox Biol
Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury. [Abstract]2023 Oct:66:102857. PMID: 37611494
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Oct:66:102857. [Abstract]
Percentage of dead FHs74Int cells, treated with indicated PUFAs (20 or 40 μM) or/and Fer-1 (5 μM), detected at 120 h after irradiation. αLA: α-Linolenic acid (40 μM); LA: Linoleic acid; DHA: Docosahexaenoic acid; AA: Arachidonic acid.
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Adv Sci (Weinh)
Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar-Modified Arabidopsis. [Abstract]2025 Aug;12(32):e00058. PMID: 40470697 -
Phytomedicine
Alpha-linolenic acid ameliorates T2DM via reshaping gut-liver axis and inflammatory GPR120-NF-κB/NLRP3 pathway in mouse and rat models. [Abstract]2025 Nov:147:157214. PMID: 40929881
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov:147:157214. [Abstract]
α-Linolenic acid (ALA, 500 mg/kg; Oral gavage; Once daily for 8 weeks) treatment effectively reduced weight gain starting at week 4.
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov:147:157214. [Abstract]
α-Linolenic acid (ALA, 500 mg/kg; Oral gavage; Once daily for 8 weeks) significantly inhibited the increase of FBG in mice starting from week 6.
α-Linolenic acid sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov:147:157214. [Abstract]
The mRNA expression levels of inflammatory cytokines (TNF-α, IL-6, IL-17A, IFN-γ, IL-10, IL-1β and IL-18) in the liver of db/db mice were quantified by qRT-PCR. The results showed that, compared with the CO group, a significant decrease in liver TNF-α, IL-6, IL-17A, interferon-γ (IFN-γ), IL-1β, and IL-18 levels was observed in theα-Linolenic acid (ALA, 500 mg/kg; Oral gavage; Once daily for 8 weeks)-treated group.
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J Ethnopharmacol
Xihuang pill suppressed primary liver cancer growth by downregulation of AFP and YAP signaling. [Abstract]2025 May 28:348:119891. PMID: 40294663 -
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Eur J Pharmacol
Polyunsaturated fatty acids drive neutrophil extracellular trap formation in nonalcoholic steatohepatitis. [Abstract]2023 Apr 15:945:175618. PMID: 36841284 -
Molecules
Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]2023 Apr 11;28(8):3375. PMID: 37110608 -
ACS Pharmacol Transl Sci
Ultrasensitive Profiling of Arachidonic Acid Metabolites Based on 5‑(Diisopropylamino)amylamine Derivatization-Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. [Abstract]2025 Oct 4;8(11):4095-4106. PMID: 41262585 -
Purity & Documentation
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Data Sheet (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)