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    Immunology/Inflammation
  2. CCR
  3. CCR1 antagonist 8

CCR1 antagonist 8 

Cat. No.: HY-120588 Purity: 99.54%
Handling Instructions

CCR1 antagonist 8 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay.

For research use only. We do not sell to patients.

CCR1 antagonist 8 Chemical Structure

CCR1 antagonist 8 Chemical Structure

CAS No. : 1295298-26-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

CCR1 antagonist 8 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay[1].

IC50 & Target[1]

CCR1

1.8 nM (IC50, in Ca2+ flux assay)

Molecular Weight

451.47

Formula

C₂₂H₁₈FN₅O₃S

CAS No.

1295298-26-8

SMILES

O=C(C1=CN=CC2=C1C=NN2C3=CC=C(F)C=C3)NC4(C5=CC(S(=O)(C)=O)=NC=C5)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (22.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2150 mL 11.0749 mL 22.1499 mL
5 mM 0.4430 mL 2.2150 mL 4.4300 mL
10 mM 0.2215 mL 1.1075 mL 2.2150 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.54%

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CCR1 antagonist 8CCRCC chemokine receptorInhibitorinhibitorinhibit

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Product Name:
CCR1 antagonist 8
Cat. No.:
HY-120588
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