5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
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5-HT Receptor
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5-HT1 Receptor
(454)
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5-HT2 Receptor
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5-HT3 Receptor
(35)
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5-HT4 Receptor
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5-HT5 Receptor
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5-HT6 Receptor
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5-HT7 Receptor
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All Product Categories
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5-HT Receptor Inhibitors
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5-HT Receptor Agonists
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5-HT Receptor Antagonists
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5-HT Receptor Activators
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5-HT Receptor Modulators
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5-HT Receptor Inducers
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5-HT Receptor Controls
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5-HT Receptor Ligands
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5-HT Receptor Related Products (1770)
Related Products (1770)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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5-HT Receptor Isoform Comparison
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Dehydroaripiprazole (Standard)
0 ImagesCat. No.: HY-100665RCAS No.: 129722-25-4Synonyms: OPC-14857 (Standard); DM-14857 (Standard)Dehydroaripiprazole (Standard) is the analytical standard of Dehydroaripiprazole. This product is intended for research and analytical applications. Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole (HY-14546) and dopamine D2/D3 receptor partial agonist. Dehydroaripiprazole also has certain affinity for serotonin 5-HT1A, 5-HT2A and 5-HT2B receptors. Dehydroaripiprazole has antipsychotic activity equivalent to Aripiprazole.
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Quetiapine-d8 hemifumarate
0 ImagesCat. No.: HY-B0031S3Quetiapine-d8 (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.
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BRL-15572 hydrochloride
0 ImagesCat. No.: HY-13200ACAS No.: 1173022-77-9BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.
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NXN-188
0 ImagesCat. No.: HY-139049CAS No.: 915036-97-4
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Lirexapride
0 ImagesCat. No.: HY-105524CAS No.: 145414-12-6Lirexapride is a 5-HT4/Dopamine D2 receptor agonist. Lirexapride stimulants gastrointestinal motor. Lirexapride can be used for research on digestive system disorders.
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SB-221284
0 ImagesCat. No.: HY-103155CAS No.: 196965-14-7SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease.
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Metoclopramide hydrochloride hydrate (Standard)
0 ImagesMetoclopramide (hydrochloride hydrate) (Standard) is the analytical standard of Metoclopramide (hydrochloride hydrate). This product is intended for research and analytical applications. Metoclopramide hydrochloride hydrate is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide hydrochloride hydrate can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis.
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5-HT2C agonist-11
0 ImagesCat. No.: HY-175515CAS No.: 3006787-99-85-HT2C agonist-11 (Compound 1) is an orally active, brain-penetrant and selective 5-HT2C receptor agonist (EC50=15 nM). 5-HT2C agonist-11 activates the Gq protein signaling pathway, promoting intracellular calcium release. 5-HT2C agonist-11 is promising for research of depression, post-traumatic stress disorder (PTSD) and neuropathic pain.
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GTS-21
0 ImagesCat. No.: HY-14564CAS No.: 148372-04-7GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti inflammatory and cognition enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist. GTS-21 can be used in age-associated memory impairment (AAMI) and Alzheimer's disease research.
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5-HT2A receptor activator-1
0 ImagesCat. No.: HY-187504CAS No.: 3129083-72-05-HT2A receptor activator-1 is an allosteric modulator of the 5-HT2A receptor, with an EC50 of 0.56 μM. 5-HT2A receptor activator-1 exerts allosteric interaction with the 5-HT2A receptor, enhances 5-HT-induced receptor activation by binding to the allosteric site, and shows no obvious agonistic activity on its own. 5-HT2A receptor activator-1 can be used in the research of neurological or psychiatric disorders.
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5-HT2A receptor agonist-11
0 ImagesCat. No.: HY-174909CAS No.: 3088416-38-75-HT2A receptor agonist-11 (Compound I-69) is a 5-HT2A receptor agonist with an EC50 of 22 nM. 5-HT2A receptor agonist-11 can be used in the research of mental illness or central nervous system disorders.
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Thiothixene hydrochloride
0 ImagesCat. No.: HY-108324ACAS No.: 49746-04-5Thiothixene hydrochloride is an antipsychotic agent. Thiothixene hydrochloride can be used for borderline and schizotypal disorder research.
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NLX-266
0 ImagesCat. No.: HY-172924CAS No.: 2170564-20-0NLX-266 is an orally active ERK1/2-biased 5-HT1A receptor agonist. NLX-266 can be used in the study of Parkinson's disease.
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5-HT2A agonist 8
0 ImagesCat. No.: HY-179291CAS No.: 3006788-03-75-HT2A agonist 8 (Compound 67) is a 5-HT2A agonist, with an EC50 of 4 nM. 5-HT2A agonist 8 can be used in the research of neuropsychiatric and neurodegenerative diseases.
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Isamoltane hemifumarate
0 ImagesCat. No.: HY-19578BCAS No.: 874882-92-5Synonyms: (±)-Isamoltane hemifumarateIsamoltane hemifumarate is a selective antagonist of 5-HT1B receptor, with an IC50 of 39 nM for inhibits the binding of [125I]ICYP to 5-HT1B recognition sites in rat brain membranes. Isamoltane hemifumarate is also a β-adrenoceptor ligand, with an IC50 of 8.4 nM. Isamoltane hemifumarate shows anxiolytic activity.
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Relenopride
0 ImagesCat. No.: HY-16729CAS No.: 1221416-43-8Synonyms: YKP10811Relenopride is a agonist of novel potent 5-HT4 receptor partial with weak binding to 5-HT 2B receptors (Ki = 31 nM).
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AZD3676
0 ImagesCat. No.: HY-122557CAS No.: 1259929-13-9AZD3676 is an orally active and blood-brain barrier-permeable ligand for 5-HT1ₐ and 5-HT1ᵦ receptors, with nanomolar binding affinity. AZD3676 is applicable to research related to cognitive impairment in Alzheimer's disease.
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GSK-588045
0 ImagesCat. No.: HY-10800CAS No.: 876922-98-4GSK-588045 is a potent 5-HT(1A/B/D) receptor antagonist. GSK-588045 shows high degree of selectivity over human ether-a-go-go related gene (hERG) potassium channels. GSK-588045 can be used for the research of neurological disease, such as depression and anxiety.
