5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
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5-HT Receptor
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5-HT1 Receptor
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5-HT2 Receptor
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5-HT3 Receptor
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5-HT4 Receptor
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5-HT5 Receptor
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5-HT6 Receptor
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5-HT7 Receptor
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All Product Categories
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5-HT Receptor Inhibitors
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5-HT Receptor Agonists
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5-HT Receptor Antagonists
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5-HT Receptor Activators
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5-HT Receptor Modulators
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5-HT Receptor Inducers
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5-HT Receptor Controls
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5-HT Receptor Ligands
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5-HT Receptor Related Products (1770)
Related Products (1770)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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5-HT Receptor Isoform Comparison
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Lofepramine hydrochloride
0 ImagesCat. No.: HY-12390ACAS No.: 26786-32-3Synonyms: Lopramine hydrochlorideLofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .
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Flibanserin-d4-1
0 ImagesSynonyms: BIMT-17-d4-1; BIMT-17BS-d4-1Flibanserin-d4-1 (BIMT-17-d4-1; BIMT-17BS-d4-1) is the d4-labeled Flibanserin (HY-A0095). Flibanserin is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-.
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Alnespirone
0 ImagesCat. No.: HY-10347CAS No.: 138298-79-0Synonyms: S-20499Alnespirone (S-20499) is a selective, orally active 5-HT1A receptor agonist (K0.5 = 0.2 nM). Alnespirone shows antidepressant-like and anxiolytic effects.
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ZINC866533340
0 ImagesCat. No.: HY-161664ZINC866533340 is a ligand for 5-HT receptor 5-HT2A with Ki of 1.6 nM. ZINC866533340 is used in AlphaFold2 technology to determines three-dimensional structure of proteins.
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Org-13011 fumarate
0 ImagesCat. No.: HY-19158ACAS No.: 142494-13-1Org 13011 fumarate is a central nervous system-active 5-HT1A receptor agonist that induces conditioned taste aversion.
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Batanopride
0 ImagesCat. No.: HY-183136CAS No.: 102670-46-2Synonyms: BMY 25801Batanopride (BMY 25801) is a selective 5-HT3 receptor antagonist. Batanopride inhibits chemotherapy-induced emesis, and prevents Cisplatin (HY-17394)-, Cyclophosphamide (HY-17420)-, Doxorubicin (HY-15142A)-, and total body irradiation-induced emesis.
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Dehydroaripiprazole hydrochloride
0 ImagesCat. No.: HY-113575CAS No.: 1008531-60-9Synonyms: OPC-14857 hydrochloride; DM-14857 hydrochlorideDehydroaripiprazole (OPC-14857) hydrochloride is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole hydrochloride. Dehydroaripiprazole hydrochloride has with antipsychotic activity equivalent to Aripiprazole.
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Binospirone hydrochloride
0 ImagesCat. No.: HY-100925CAS No.: 102908-60-1Binospirone hydrochloride serves as an antagonist of the 5-HT1A receptor.
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Levemopamil
0 ImagesCat. No.: HY-113581CAS No.: 101238-51-1Levemopamil is a calcium channel blocker and 5-HT2 receptor antagonist. Levemopamil exerts renoprotective effects against ischemic acute kidney injury. Levemopamil is applicable to research related to ischemic acute renal failure.
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Eptapirone fumarate
0 ImagesCat. No.: HY-19946ACAS No.: 179756-85-5Synonyms: F 11440 fumarateEptapirone fumarate (F11440 fumarate) is a potent, selective and orally active 5-HT1A receptor agonist (pKi = 8.33). Eptapirone fumarate can inhibit cAMP production. Eptapirone fumarate can reduce 5-HT levels and increase corticosterone levels. Eptapirone fumarate shows potent anxiolytic and antidepressant potential. Eptapirone fumarate can be used for the research of neurological disease, such as anxiety and depression.
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Hymenidin
0 ImagesCat. No.: HY-118328CAS No.: 107019-95-4
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Myristicin (Standard)
0 ImagesMyristicin (Standard) is the analytical standard of Myristicin. This product is intended for research and analytical applications. Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc.
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LY215840
0 ImagesCat. No.: HY-103148CAS No.: 137328-52-0LY215840, a 5-HT7 receptor ligand and a 5-HT2 receptor antagonist, blocks serotonin-induced relaxation in canine coronary artery.
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ALD-52
0 ImagesALD-52 (1-Acetyl-LSD) is a prodrug for LSD. ALD-52 shows an affinity to 5-HT1A, 5-HT2A and 5-HT2C with a sub>D values of 1054, 174 and 10.2 nM, respectively. ALD-52 is converted to LSD and induces a head-twitch response (HTR) in vivo. ALD-52 can be used for hallucinogen research.
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NAS-181
0 ImagesCat. No.: HY-135507CAS No.: 205242-62-2NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.
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Nefazodone-d6 hydrochloride
0 ImagesCat. No.: HY-B1396SSynonyms: BMY-13754-d6; MJ-13754-1-d6Nefazodone-d6 (hydrochloride) is the deuterium labeled Nefazodone hydrochloride. Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity.
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5-HT2C agonist-9
0 ImagesCat. No.: HY-174898CAS No.: 2873459-44-85-HT2C agonist-9 (Compound 33) is a 5-HT2C agonist with an EC50 of 1.4 nM for h5-HT2C. 5-HT2C agonist-9 can be used in the research of diseases such as depression, drug addiction, alcoholism, PTSD and neuropathic pain.
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SUN C5174
0 ImagesCat. No.: HY-13708CAS No.: 191592-36-6SUN C5174 is an antagonist for 5-HT2 receptor with a mild sympathomimetic efficacy. SUN C5174 attenuates disorders in various experimental models of peripheral circulatory disturbance, and exhibits good pharmacokinetic properties.
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5-HT6/5-HT2AR antagonist-1
0 ImagesCat. No.: HY-145862CAS No.: 2763654-60-85-HT6/5-HT2AR antagonist-1 is a potent dual 5-HT6/5-HT2AR antagonist with Ki values of 11 nM and 39 nM, respectively.
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SDZ 216-525
0 ImagesCat. No.: HY-116309CAS No.: 141533-35-9SDZ 216-525 is a selective silent antagonist of 5-HT1A receptor.
