5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
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5-HT Receptor
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5-HT1 Receptor
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5-HT2 Receptor
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5-HT3 Receptor
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5-HT4 Receptor
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5-HT5 Receptor
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5-HT6 Receptor
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5-HT7 Receptor
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All Product Categories
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5-HT Receptor Inhibitors
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5-HT Receptor Agonists
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5-HT Receptor Antagonists
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5-HT Receptor Activators
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5-HT Receptor Modulators
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5-HT Receptor Inducers
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5-HT Receptor Controls
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5-HT Receptor Ligands
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5-HT Receptor Related Products (1770)
Related Products (1770)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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5-HT Receptor Isoform Comparison
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Quetiapine-d8 fumarate
0 ImagesCat. No.: HY-B0031S2CAS No.: 1185247-12-4Quetiapine-d8 (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.
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2,6-DMA hydrochloride
0 ImagesCat. No.: HY-W713312CAS No.: 3904-11-82,6-DMA hydrochloride is a serotonin 5-HT2 receptor agonist with an apparent pA2 value of 5.09.
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Olanzapine-d4
0 ImagesCat. No.: HY-14541S1CAS No.: 1252611-62-3Synonyms: LY170053-d4
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Arbortristoside A
0 ImagesCat. No.: HY-127080CAS No.: 97145-52-3Arbortristoside A is an orally active inhibitor of prostaglandin (prostaglandin), histamine (histamine) and serotonin (serotonin). Arbortristoside A mediates anti-inflammatory, analgesic, anti-allergic, immunomodulatory, antiviral and anti-ulcerogenic effects, and also exhibits in vitro anticancer activity. Arbortristoside A can be used in research related to human hepatocellular carcinoma, breast cancer, fibrosarcoma, leishmaniasis, allergic diseases, viral infections and gastric ulcers.
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4-CAB hydrochloride
0 ImagesCat. No.: HY-114859CAS No.: 23292-08-24-CAB hydrochloride is an analog of p-chloroamphetamine, a psychoactive compound which inhibits the reuptake of serotonin (IC50 = 330 nM) and dopamine (IC50 = 2.3 μM).
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18-Methoxycoronaridine hydrochloride
0 ImagesCat. No.: HY-106980ACAS No.: 266686-77-5Synonyms: (-)-18-Methoxycoronaridine hydrochloride18-Methoxycoronaridine ((-)-18-Methoxycoronaridine) hydrochloride is an orally active and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist. 18-Methoxycoronaridine hydrochloride is an inhibitor of serotonin transporter (SERT) and norepinephrine transporter (NET), with IC50 values of 51.6 μM and 121 μM for SERT and NET, respectively. 18-Methoxycoronaridine hydrochloride inhibits the function of SERT and NET, promotes 5-HT3A receptor desensitization, blocks α3β4 nAChR, and modulates receptor signaling pathways associated with reinforcement. 18-Methoxycoronaridine hydrochloride also exhibits potent antiparasitic activity. 18-Methoxycoronaridine hydrochloride can be used in research related to depression, obesity, alcoholism, smoking addiction, and cutaneous leishmaniasis.
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Flibanserin (Standard)
0 ImagesSynonyms: BIMT-17 (Standard); BIMT-17BS (Standard)Flibanserin (Standard) is the analytical standard of Flibanserin. This product is intended for research and analytical applications. Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-.
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(R)-Indeloxazine benzenesulfonate
0 ImagesCat. No.: HY-138257ACAS No.: 1623762-83-3Synonyms: AS1069562; (R)-YM-08054 benzenesulfonate(R)-Indeloxazine benzenesulfonate (AS1069562) is an orally active 5-HT and NE reuptake inhibitor, with IC50 values of 0.35 μM and 3.3 μM, respectively. (R)-Indeloxazine benzenesulfonate (AS1069562) possesses curative-like analgesic effect. (R)-Indeloxazine benzenesulfonate (AS1069562) might improve nerve function impairment via the amelioration of neurotrophic support.
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Pizotifen (Standard)
0 ImagesSynonyms: Pizotyline (Standard); BC-105 (Standard)Pizotifen (Standard) (Pizotyline (Standard)) is the analytical standard of Pizotifen (HY-B0115). This product is intended for research and analytical applications. Pizotifen (Pizotyline) is a 5-HT2 receptor antagonist. Pizotifen inhibits the Wnt/β-catenin-EMT signaling pathway and induces mitochondria-mediated Apoptosis. Pizotifen causes transient ERK1/2 phosphorylation and restores ATP. Pizotifen blocks Serotonin (HY-B1473A)-mediated platelet activation, inhibits Serotonin-enhanced ADP-induced platelet aggregation, and prolongs carotid artery occlusion and tail bleeding time. Pizotifen exhibits anticancer activity against gastric cancer and colon cancer. Pizotifen exerts neuroprotective effects in the striatum of R6/2 mice. Pizotifen can be used for research on gastric cancer, colon cancer, Huntington's disease, metastasis, and thromboembolic diseases.
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Minesapride hydrobromide
0 ImagesCat. No.: HY-109065ACAS No.: 1184661-33-3Synonyms: DSP-6952 hydrobromideMinesapride hydrobromide (DSP-6952 hydrobromide) is an orally active, selective 5-HT4 receptor partial agonist. Minesapride hydrobromide enhances gastrointestinal motility, colonic transit and defecation function, and inhibits visceral hypersensitivity. Minesapride hydrobromide does not inhibit/induce cytochrome P450 isozymes, has no significant affinity for hERG, and does not trigger the risk of cardiac ischemia via coronary vasoconstriction. Minesapride hydrobromide can be used in research related to constipation-predominant irritable bowel syndrome, chronic constipation, atonic constipation, spastic constipation, functional constipation and functional dyspepsia.
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Risperidone mesylate
0 ImagesCat. No.: HY-11018BCAS No.: 666179-96-0Synonyms: R 64 766 mesylateRisperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
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4-Iodoamphetamine hydrochloride
0 ImagesCat. No.: HY-131556CAS No.: 21894-58-6Synonyms: p-Iodoamphetamine hydrochloride4-Iodoamphetamine (p-Iodoamphetamine) hydrochloride is a halogenated amphetamine featuring an iodine atom at the para position of the phenyl group. 4-Iodoamphetamine hydrochloride selectively induces serotonin release and inhibits reuptake by rat brain synaptosomes.
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Ondansetron hydrochloride dihydrate (Standard)
0 ImagesSynonyms: GR 38032 hydrochloride dihydrate (Standard); SN 307 hydrochloride dihydrate (Standard)Ondansetron (hydrochloride dihydrate) (Standard) is the analytical standard of Ondansetron (hydrochloride dihydrate). This product is intended for research and analytical applications. Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery.
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GR 113808 (Standard)
0 ImagesGR 113808 (Standard) is the analytical standard of GR 113808. This product is intended for research and analytical applications. GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.
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Zacopride hydrochloride (Standard)
0 ImagesZacopride (hydrochloride) (Standard) is the analytical standard of Zacopride (hydrochloride). This product is intended for research and analytical applications. Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist with Kis of 0.38 and 373 nM for 5-HT3 and 5-HT4 receptor, respectively. Zacopride hydrochloride is also a moderate IK1 channel agonist. Zacopride hydrochloride exerts significant antiarrhythmic and cardiac protective effects.
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SC-53116 hydrochloride
0 ImagesCat. No.: HY-123747ACAS No.: 879208-42-1SC-53116 hydrochloride is a selective 5-HT4 receptor agonist with EC50 at 23 nM.
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NAS-181 dimesylate (Standard)
0 ImagesCat. No.: HY-103156RCAS No.: 1217474-40-2NAS-181 dimesylate (Standard) is the analytical standard of NAS-181 dimesylate (HY-103156). This product is intended for research and analytical applications. NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.
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Masupirdine mesylate (Standard)
0 ImagesCat. No.: HY-109118ARCAS No.: 1791396-46-7Synonyms: SUVN-502 mesylate (Standard)Masupirdine mesylate (Standard) is the analytical standard of Masupirdine (mesylate) (HY-109118A). This product is intended for research and analytical applications. Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally active, and brain-penetrating 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate has pro-cognitive effects on all stages of cognition (acquisition, consolidation, and retention), and can reverse Scopolamine (HY-N0296), MK-801 (HY-15084B)-induced and aging-related memory deficits. Masupirdine mesylate can be used in the research of Alzheimer's disease.
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Revospirone
0 ImagesCat. No.: HY-111985CAS No.: 95847-87-3Synonyms: BAY Vq 7813Revospirone (BAY Vq 7813) is a partial agonist of the 5-HT1A receptor with a Ki of 2 nmol/L. Revospirone inhibits adenylate cyclase activity with an IC50 of 124 nmol/L.
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Blonanserin-d5
0 ImagesCat. No.: HY-13575S1CAS No.: 1346599-86-7Synonyms: AD-5423-d5Blonanserin-d5 (AD-5423-d5) is a deuterium labeled Blonanserin (HY-13575). Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic.
