2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W095774
    (E)-N-(3-Methoxyphenyl)cinnamamide
    		Inhibitor
    (E)-N-(3-Methoxyphenyl) cinnamamide (Compound 5h) is a weakly selective inhibitor of MMP-2 and MMP-9, with weak inhibitory activity against hMMP-2 and hMMP-9, showing IC50 values of 1674.81 nM and 1658.63 nM, respectively, and low selectivity for MMP-1. (E)-N-(3-Methoxyphenyl) cinnamamide is applicable for cancer research.
    (E)-N-(3-Methoxyphenyl)cinnamamide
  • HY-149725
    proMMP-9 selective inhibitor-1
    		Inhibitor
    proMMP-9 selective inhibitor-1 (compound 33) is a highly potent and selective inhibitor of proMMP-9 activation.
    proMMP-9 selective inhibitor-1
  • HY-146216
    MMP-9-IN-3
    		Inhibitor
    MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers.
    MMP-9-IN-3
  • HY-RS08559
    Mmp9 Rat Pre-designed siRNA Set A
    		Inhibitor

    Mmp9 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp9 Rat Pre-designed siRNA Set A
  • HY-12168B
    (Rac)-Tanomastat
    		Inhibitor
    (Rac)-Tanomastat ((Rac)-BAY 12-9566) is the racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models.
    (Rac)-Tanomastat
  • HY-RS08553
    Mmp7 Rat Pre-designed siRNA Set A
    		Inhibitor

    Mmp7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp7 Rat Pre-designed siRNA Set A
  • HY-175276
    JNK-IN-24
    		Inhibitor
    JNK-IN-24, a JNK inhibitor, is an anti-metastatic cancer agent. JNK-IN-24 downregulates JNK and MMP1 expression in Scrib knockdown induced cancer tissues. JNK-IN-24 promotes recovery from tumorous wing disc phenotype of ScribRNAi. JNK-IN-24 can be used for the study in various epithelial cell-derived cancers.
    JNK-IN-24
  • HY-N15588
    Smyrindiol
    		Inhibitor
    Smyrindiol is a compound found in Dorstenia turbinate. Smyrindiol exerts anti-inflammatory and antimicrobial activities by inhibiting the secretion of tumor-associated proteases (MMP-2). Smyrindiol can be used in the study of brain tumors such as glioblastoma.
    Smyrindiol
  • HY-NP115
    Highly purified Type XI collagen, from chick articular cartilage
    Highly purified Type XI collagen, from chick articular cartilage (Chick Type XI collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type XI collagen, from chick articular cartilage
  • HY-P5380
    TNO211
    		Substrate 99.41%
    TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 can specifically detect MMP activity (Ex/Em = 340/485 nm).
    TNO211
  • HY-162039
    MMP-11-IN-1
    MMP-11-IN-1 (compound 9) is a new class of phosphinate prodrug. MMP-11-IN-1 is a glycosyl ester of RXP03 and improves blood–brain barrier (BBB) behavior.
    MMP-11-IN-1
  • HY-W185542
    E09241
    		Inhibitor
    E09241 is an orally active osteoclastogenesis inhibitor. E09241 reduces the RANKL-induced expression of NFATc1 and MMP-9 by activating Wnt/β-catenin. E09241 increases the OPG/RANKL ratio by upregulating OPG expression, inhibits bone resorption, promotes bone formation and prevents ovariectomy-related bone loss. E09241 can be used in the research of osteoporosis.
    E09241
  • HY-12723R
    Apomorphine (Standard)
    		Inhibitor
    Apomorphine ((-)-Apomorphine) (Standard) is the analytical standard of Apomorphine (HY-12723). This product is intended for research and analytical applications. Apomorphine is a potent dopamine receptor agonist. Apomorphine also inhibit MAO-A and MAO-B. Apomorphine exerts neuroprotective effect and can relax rat corpus cavernosum. Apomorphine can inhibit ROS production, DNA fragmentation and inibit JNK and ERK1/2 phosphorylation. Apomorphine can enhance degradation of intracellular Aβ40 and Aβ42, reduces tau protein levels and inhibit MMP-9 expression. Apomorphine is a highly potent radical scavenger and iron chelator. Apomorphine can be used for the researches of dementia, parkinson's disease, alzheimer disease, breast carcinoma, and erectile dysfunction.
    Apomorphine (Standard)
  • HY-14239
    Rebimastat
    		Inhibitor
    Rebimastat (BMS 275291) is an orally active, broad-spectrum MMP inhibitor and non-peptide collagen mimetic. Rebimastat has some selectivity because it does not inhibit all MMP activities. Rebimastat can be used in the research of colorectal cancer.
    Rebimastat
  • HY-N0735R
    Phellodendrine chloride (Standard)
    		Inhibitor
    Phellodendrine chloride (Standard) is the analytical standard of Phellodendrine chloride (HY-N0735). Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway.
    Phellodendrine chloride (Standard)
  • HY-120015
    BE-16627B
    		Inhibitor
    BE-16627B is a metalloproteinase inhibitor. BE-16627B can be isolated from microbial cultures. BE-16627B can inhibit metalloproteinases in enzyme assays. BE-16627B reduces the number and size of HT1080 cell nodules on lung surface in mouse models. BE-16627B inhibits growth of HT1080 cells in mice. BE-16627B can be studied in anti-cancer research.
    BE-16627B
  • HY-180324
    Candidone
    		Inhibitor
    Candidone is a type of flavanone phenolic compound with anti-cancer and antibacterial activities. Candidone inhibits the proliferation of hepatoblastoma and cholangiocarcinoma cells and induces their apoptosis by up-regulating p21, Bax, and caspase 3/9, and down-regulating Bcl-2 and survivin. It reduces the metastatic ability of cancer cells by inhibiting the expression of phosphorylated p38 and matrix metalloproteinase MMP-9. Candidone has inhibitory effects on multidrug-resistant bacterial strains. Candidone binds to the base pairs of DNA in a groove-binding manner, thereby slightly altering the conformation of DNA.
    Candidone
  • HY-RS08530
    Mmp14 Rat Pre-designed siRNA Set A
    		Inhibitor

    Mmp14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp14 Rat Pre-designed siRNA Set A
  • HY-147867
    MMP-2/9-IN-1
    		Inhibitor
    MMP-2/9-IN-1 (Compound 4a) is a potent dual MMP-2 and MMP-9 inhibitor with IC50 values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation.
    MMP-2/9-IN-1
  • HY-P2089
    Dnp-PYAYWMR
    Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm.
    Dnp-PYAYWMR
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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