2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123736
    Ro 32-7315
    		Inhibitor
    Ro 32-7315 is a TNF-α converting enzyme (TACE) inhibitor.
    Ro 32-7315
  • HY-119138
    R-130823
    		Inhibitor
    R-130823 is an orally active, highly selective p38α inhibitor with an IC50 of 22 nM against p38α, an IC50 of 820 nM against p38β, and no activity against p38γ or p38δ. R-130823 downregulates downstream cartilage degradation and inflammatory mediators, and inhibits the release of MMP-13, MMP-1 and PGE2. R-130823 reduces hind paw swelling, improves hyperalgesia, and blocks arthritis progression. R-130823 is applicable to research related to osteoarthritis and rheumatoid arthritis.
    R-130823
  • HY-183784
    P2X7R antagonist-1
    		Inhibitor
    P2X7R antagonist-1 is an orally active P2X7 receptor antagonist with an IC50 of 3.57 μM. P2X7R antagonist-1 inhibits the proliferation, invasion and metastasis abilities of cancer cells. P2X7R antagonist-1 downregulates the expression of FAK and MMP-9. P2X7R antagonist-1 suppresses tumor growth and metastasis in a mouse breast cancer model. P2X7R antagonist-1 promotes the activation of CD4 and CD8 T cells. P2X7R antagonist-1 can be used in breast cancer-related research.
    P2X7R antagonist-1
  • HY-P992307
    Anti-TIMP-1 Antibody
    Anti-TIMP-1 Antibody is a monoclonal antibody that targets TIMP1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-TIMP-1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-TIMP-1 Antibody
  • HY-P991478
    RLVT-14-02
    		Inhibitor
    RLVT-14-02 is a human monoclonal antibody (mAb) targeting MMP14. RLVT-14-02 can be used in neuropathic pain research.
    RLVT-14-02
  • HY-172088
    Tubulin/MMP-IN-3
    		Inhibitor
    Tubulin/MMP-IN-3 (Compound 15j) is the dual inhibitor for tubulin polymerization and MMP, and inhibits MMP-2 and MMP-9 with IC50 of 21.13 μM and 19.24 μM. Tubulin/MMP-IN-3 inhibits NF-κB signaling pathway, causes mitochondrial dysfunction and the apoptosis through a mitochondrial-dependent pathway. Tubulin/MMP-IN-3 exhibits antiproliferative activity in a variety of cancer cells, arrests the cell cycle at G2/M phase, and exhibits antitumor efficacy in mouse models.
    Tubulin/MMP-IN-3
  • HY-P10174
    ADAM-17 Substrate
    ADAM-17 Substrate is a fluorescent substrate of ADAM.
    ADAM-17 Substrate
  • HY-171776
    OPB-3206
    		Inhibitor
    OPB-3206 is a selective matrix metalloproteinase (MMP) inhibitor. OPB-3206 inhibits interstitial collagenase, gelatinase A (MMP-2), gelatinase B (MMP-9) and stromelysin with IC50 values of 7×10-7 M, 5×10-6 M, 5×10-7 M and 2×10-6 M, respectively. OPB-3206 reversibly binds to the zinc-binding region of MMPs, preventing the activation of MMP-9 and reducing extracellular matrix degradation to inhibit tumor lung metastasis. OPB-3206 is promising for research of lung metastasis of osteosarcoma.
    OPB-3206
  • HY-NP130
    Highly purified Type II collagen, from goat articular cartilage
    Highly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type II collagen, from goat articular cartilage
  • HY-RS00272
    Adam17 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Adam17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Adam17 Mouse Pre-designed siRNA Set A
  • HY-165386
    TU-100
    		Inhibitor
    TU-100 is a Japanese herbal medicine. TU-100 exhibits anti-cancer effects by regulating cancer-associated fibroblasts (CAFs) in the TME. TU-100 can antagonize the M2 polarization phenotype of macrophages in the tumor microenvironment by suppressing the TLR4/NF-κB/STAT3 axis. TU-100 can inhibit the high expression of MMP-2, COX-2, and VEGF in TAMs.
    TU-100
  • HY-153913
    MMP-9-IN-7
    		Inhibitor
    MMP-9-IN-7 is a potent MMP9 inhibitor with an IC50 of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research.
    MMP-9-IN-7
  • HY-12270S
    T-5224-d8
    T-5224-d8 is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.
    T-5224-d<sub>8</sub>
  • HY-100113A
    Buloxibutid hydrochloride
    		Inhibitor
    Buloxibutid (AT2 receptor agonist C21) hydrochloride is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid hydrochloride exerts vasodilatory, anti-inflammatory, antifibrotic (promoting the expression of collagenase MMP-13) and tissue repair effects mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway and inflammatory NF-κB pathway. Buloxibutid hydrochloride can be used in research related to idiopathic pulmonary fibrosis, hypertension, systemic sclerosis and other conditions.
    Buloxibutid hydrochloride
  • HY-114581
    U27391
    		Inhibitor
    U27391 is a metalloproteinase inhibitor. U27391 inhibits rhIL-1β Induced proteoglycan loss.
    U27391
  • HY-109097A
    Otaplimastat hydrochloride
    		Inhibitor
    Otaplimastat (SP-8203) hydrobromide, a matrix metalloproteinase (MMP) inhibitor, blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in a competitive manner. Otaplimastat hydrobromide also exhibits anti-oxidant activity. Otaplimastat hydrobromide can be used for the research of brain ischemic injury.
    Otaplimastat hydrochloride
  • HY-137521
    Z-PDLDA-NHOH
    Z-PDLDA-NHOH is a potent and specific inhibitor of vertebrate collagenase.
    Z-PDLDA-NHOH
  • HY-122483
    Diethyl pyimDC
    		Inhibitor
    iethyl pyimDC is a collagen prolyl 4-hydroxylase (CP4H1) inhibitor inhibitor with the IC50 of 2.6μM. Diethyl pyimDC can be used for study of antifibrotic and antimetastatic.
    Diethyl pyimDC
  • HY-121096
    Funalenone
    		Inhibitor
    Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM.
    Funalenone
  • HY-NP122
    Highly purified Type I collagen, from porcine skin
    Highly purified Type I collagen, from porcine skin (Porcine Type I collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type I collagen, from porcine skin
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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