NADPH Oxidase
NOX
NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The ROS generated by NADPH oxidases have crucial roles in various physiological processes, including innate immunity, modulation of redox-dependent signalling cascades, and as cofactors in the production of hormones.
NOX enzymes are a family of transmembrane proteins comprising seven members (NOX1-NOX5 and DUOX1 and DUOX2), each with a specific tissue distribution and activation mechanism. They catalyze the reduction of molecular oxygen to superoxide anion, which in turn reacts quickly to generate other ROS, such as hydrogen peroxide. Although basic NOX activity is crucial for normal physiology, overshooting activity of NOX enzymes leads to disease. NADPH oxidases are increasingly recognized as interesting drug targets.
NADPH Oxidase Isoform Specific Products
All Product Categories
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NADPH Oxidase Related Products (105)
Related Products (105)
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Antibodies (3)
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NADPH Oxidase Isoform Comparison
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Thioredoxin reductase
0 ImagesThioredoxin reductase (TrxR) is a selenocysteine-containing NADPH-dependent disulfide oxidoreductase derived from rat liver that utilizes NADPH to reduce oxidized thioredoxin. Thioredoxin reductase can utilize the reducing capacity of human erythrocytes to study the uptake and reduction of α-Lipoic Acid (HY-N0492), and can also be used to investigate the activation mechanism of transglutaminase 2 (TG2) in the extracellular matrix using thioredoxin.
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Y-27632 hydrochloride hydrate
0 ImagesY-27632 hydrochloride hydrate is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 hydrochloride hydrate exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 hydrochloride hydrate enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 hydrochloride hydrate induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 hydrochloride hydrate promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade.
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p67phox-IN-1
0 Imagesp67phox-IN-1 (Formula IIIa Compound) is an inhibitor targeting the interaction between Rac GTPase and p67phox protein.
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Hidrosmin
0 ImagesCat. No.: HY-105946CAS No.: 115960-14-0
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VAS 3947
0 ImagesVAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.
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(Rac)-Nebivolol
0 ImagesCat. No.: HY-B0203BCAS No.: 99200-09-6Synonyms: (Rac)-R 065824(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.
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Glucose 6-phosphate dehydrogenase (yeast, recombinant)
0 ImagesCat. No.: HY-125863BCAS No.: 9001-40-5Synonyms: G6PD (yeast, recombinant)Glucose 6-phosphate dehydrogenase (yeast, recombinant) (G6PD (yeast, recombinant)) is a recombinant enzyme requiring NADP+ as a coenzyme. Glucose 6-phosphate dehydrogenase (yeast, recombinant) catalyzes the oxidative dehydrogenation of glucose-6-phosphate to form 6-phosphoglucono-δ-lactone, as well as the reduction of NADP+ to NADPH. Glucose 6-phosphate dehydrogenase (yeast, recombinant) relies on the amino acid Arg-52 to bind NADP+. Glucose 6-phosphate dehydrogenase (yeast, recombinant) undergoes competitive inhibition by NADPH and strong inhibition by zinc ions (Zn2+). Glucose 6-phosphate dehydrogenase (yeast, recombinant) is an enzyme in the pentose phosphate pathway, which is one of the glucose metabolic pathways. Glucose 6-phosphate dehydrogenase (yeast, recombinant) can be used for the quantitative detection of ATP, glucose and creatine kinase.
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Dihydrotamarixetin
0 ImagesSynonyms: 4'-O-Methyldihydroquercetin; Blumeatin ADihydrotamarixetin (4'-O-Methyldihydroquercetin; Blumeatin A) is a flavonoid with a saturated 2,3-bond and a non-catechol B ring. Dihydrotamarixetin acts as an inhibitor of NADPH Oxidase.
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ML171 (Standard)
0 ImagesSynonyms: 2-Acetylphenothiazine (Standard); 2-APT (Standard)ML171 (Standard) is the analytical standard of ML171. This product is intended for research and analytical applications. ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay.
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NOX2-IN-3
0 ImagesNOX2-IN-3 (compound 3) is an inhibitor of NOX2 (NADPH Oxidase 2). NOX2-IN-3 sensitizes tumor cells to MRTX1133 (HY-134813).
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NoxA1ds TFA
0 ImagesCat. No.: HY-P1435ANoxA1ds TFA is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds TFA can be used in the study of hypertension, atherosclerosis and tumors.
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YF-Mo1
0 ImagesCat. No.: HY-157450CAS No.: 1119826-36-6YF-Mo1 (compound 9) is a CBR1 inhibitor with an IC50 value of 1.1 μM.
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CPP11G
0 ImagesCat. No.: HY-185008CAS No.: 1580464-93-2CPP11G (Compound 11g) is a highly selective NADPH oxidase 2 (Nox2) inhibitor (IC50=20 μM). CPP11G is promising for research of inflammatory diseases (e.g., vasculitis, atherosclerosis) and Nox2-overactivated pathologies (e.g., ischemia-reperfusion injury).
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Niazirin
0 ImagesNiazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis.
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MJ33
0 ImagesCat. No.: HY-136271CAS No.: 137300-78-8MJ-33 is a competitive phospholipase A₂ (PLA₂) inhibitor with an IC50 of 0.3 μM. MJ-33 inhibits the activation of NOX2 by blocking the PLA₂ activity of Prdx6, thereby reducing the production of ROS. MJ-33 effectively inhibits the activity of acidic PLA₂ (pH 4.0), reduces the degradation of pulmonary surfactant phosphatidylcholine (PC), but has no effect on alkaline PLA₂ (pH 8.5). MJ-33 significantly alleviates lung oxidative damage induced by ischemia-reperfusion (I/R). MJ-33 significantly inhibits the invasive, migratory and adhesive abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 can be used to study ROS-related diseases and prostate cancer.
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Thioredoxin Reductase (NADPH), Yeast
0 ImagesCat. No.: HY-P2759BThioredoxin Reductase (NADPH), Yeast is an enzyme belonging to the flavoprotein family of pyridine nucleotide-disulfide oxidoreductases. Thioredoxin reductase (TrxR), a component of the thioredoxin system, including thioredoxin (Trx) and NADPH, catalyzes the transfer of electrons from NADPH to Trx, acts as a reductant of disulfide-containing proteins and participates in the defense system against oxidative stresses.
