Na+/K+ ATPase
Sodium potassium pump
Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.
The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.
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Na+/K+ ATPase Related Products (151)
Related Products (151)
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Antibodies (11)
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Citreoviridin-13C23
0 ImagesCat. No.: HY-N6745SCitreoviridin-13C23 is 13C labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans.
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1,2-Di-13(Z)-docosenoyl-3-oleoyl-rac-glycerol
0 ImagesCat. No.: HY-169036CAS No.: 60003-02-31,2-Di-13(Z)-docosenoyl-3-oleoyl-rac-glycerol (1-Paimitin-2-olein-3-linolenin) is a triacylglycerol that contains 13(Z)-docosenoic acid at the sn-1 and sn-2 positions and Oleic acid (HY-N1446) at the sn-3 position.
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Tegoprazan-d6
0 ImagesCat. No.: HY-17623SSynonyms: CJ-12420-d6; RQ-00000004-d6Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases.
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ADN 138
0 ImagesCat. No.: HY-113738CAS No.: 99434-90-9ADN-138 is an aldose reductase inhibitor. ADN-138 reduces sorbitol levels in diabetic nerves and results in significant increases in MNCV and Na+, K+-ATPase in the nerves. ADN-138 can be used in the research of diabetic nerve complications.
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Ro 18-5364
0 ImagesCat. No.: HY-115312CAS No.: 101387-98-8Ro 18-5364 is an inhibitor of gastric H+/K+ ATPase, which has the effect of inhibiting the activity of the enzyme. Ro 18-5364 has a very strong inhibitory effect on gastric mucosal H+/K+ ATPase, and the inhibitory effect is more significant at low pH. At the same time, there is no selectivity difference between the two enantiomers of H+/K+ ATPase, and its inhibitory effect can be studied and verified by a variety of experimental methods, including inhibition of enzyme activity, proton transport, and studies on its binding.
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JAK05
0 ImagesCat. No.: HY-170586JAK05 exhibits inhibitory activity against Helicobacter pylori, inhibits strains J63, J196 and J107 with MIC of 3-5 µg/mL. JAK05 exhibits binding affinity to H+/K+-ATPase, COX-1/2, TNF-α and PGE2, reveals antioxidant and anti-inflammatory activities. JAK05 exhibits anti-ulcer activity in rat ethanol-induced gastric ulcer models.
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Gitoxin (Standard)
0 ImagesCat. No.: HY-136933RCAS No.: 4562-36-1Gitoxin (Standard) is the analytical standard of Gitoxin (HY-136933). This product is intended for research and analytical applications. Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na+/K+-ATPase inhibitor, with an IC50 of 1.18e-6 M against the porcine high-affinity subtype and an IC50 of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure.
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Prilocaine Hydrochloride-d7
0 ImagesCat. No.: HY-W704786CAS No.: 2509098-78-4Prilocaine Hydrochloride-d7 is the deuterium labeled Prilocaine hydrochloride (HY-B0137A). Prilocaine hydrochloride, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects.
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AR-HO47108
0 ImagesCat. No.: HY-124742CAS No.: 248281-68-7AR-HO47108 is an orally active reversible Na+/K+ ATPase inhibitor. AR-HO47108 reversibly blocks the final step of gastric acid secretion by competitively binding to the potassium ion binding site of the Na+/K+ ATPase in the gastric wall cells. AR-HO47108 can be used for research on diseases related to excessive gastric acid secretion, such as peptic ulcers.
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Oleic acid-13C-1
0 ImagesSynonyms: 9-cis-Octadecenoic acid-13C-1; 9Z-Octadecenoic acid-13C-1Oleic acid-13C-1 is the 13C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.
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Lansoprazole sulfone (Standard)
0 ImagesCat. No.: HY-W008614RCAS No.: 131926-99-3Synonyms: AG-1813 (Standard)Lansoprazole sulfone (AG-1813) (Standard) is the analytical standard of Lansoprazole sulfone (HY-W008614). This product is intended for research and analytical applications. Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H+, K+-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease.
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ME 3407
0 ImagesCat. No.: HY-19133CAS No.: 133903-90-9Synonyms: EF-4040ME-3407 (EF-4040) is a H+-K+-ATPase redistribution disruptor and myosin light chain kinase (MLCK) and protein kinase A inhibitor. ME-3407 blocks gastric acid secretion and aminopyrine accumulation by inhibiting microsomal-to-apical membrane redistribution of H+-K+-ATPase and suppressing MLCK-mediated myosin light chain phosphorylation. ME-3407 is promising for research of peptic ulcer.
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Leminoprazole
0 ImagesCat. No.: HY-105094CAS No.: 104340-86-5Synonyms: NC 1300O3Leminoprazole (NC 1300O3) is an inhibitor for acid pump, H+ K+-ATPase,. Leminoprazole stimulates the secretion and synthesis of gastric mucus, attenuates gastric ulcers. Leminoprazole is orally active.
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SPAI-1
0 ImagesCat. No.: HY-P3711CAS No.: 131359-77-8SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na+, K+-ATPase and H+, K+-ATPase in vitro, stimulates Mg2+-ATPase.
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PROTAC PI3K/110β degrader-2
0 ImagesCat. No.: HY-174469CAS No.: 3070438-79-5PROTAC PI3K/110β degrader-2 is a VHL-recruiting PI3K/110β PROTAC degrader, with DC50 values of 1.258 μM and 2.185 μM in MCF-7/ADM and A549/DDP cells, respectively. PROTAC PI3K/110β degrader-2 induces proteasomal degradation of PI3K/110β, inhibits phosphorylation of AKT and expression of Bcl-2, while suppressing the activity and expression of P-gp. It also induces endoplasmic reticulum stress and mitochondrial apoptosis via the PERK/CHOP pathway. PROTAC PI3K/110β degrader-2 exerts anti-tumor activity against multidrug-resistant cancer cells both in vitro and in vivo, and produces a synergistic effect when combined with Doxorubicin (HY-15142A) or Cisplatin (HY-17394), making it applicable for the research of multidrug-resistant cancers.
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ASI-222
0 ImagesCat. No.: HY-105431CAS No.: 59006-00-7ASI-222 is an aminosugar cardiac glycoside. ASI-222 can inhibit Na+/K+ ATPase and show positive inotropic effect. ASI-222 can be used for the research of cardiovascular disease.
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Deacetyltanghinin
0 ImagesDeacetyltanghinin is a selective inhibitor targeting Na+/K+ ATPase, acting through non-covalent binding but is highly cardiotoxic. Deacetyltanghinin inhibits Na+/K+ ATPase activity, induces cancer cell apoptosis (involving caspase pathway activation), and at the same time affect the TXA2-PGI2 balance in the rabbit heart. Deacetyltanghinin has significant anti-cancer activity and is mainly used in the research field of targeted therapy of malignant tumors such as breast cancer and lung cancer. At the same time, attention should be paid to the regulation of its cardiotoxicity.
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17(S)-HETE
0 ImagesCat. No.: HY-116050CAS No.: 183509-25-317S-HETE is arachidonic acid metabolite through cytochrome P-450 pathways. 17S-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.
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Cryptanoside A
0 ImagesCat. No.: HY-N9149CAS No.: 98570-81-1
