Prostaglandin Receptor
Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.
Prostaglandin Receptor Isoform Specific Products
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Prostaglandin Receptor Inhibitors
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Prostaglandin Receptor Agonists
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Prostaglandin Receptor Antagonists
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Prostaglandin Receptor Activators
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Prostaglandin Receptor Modulators
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Prostaglandin Receptor Inducers
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Prostaglandin Receptor Degrader
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Prostaglandin Receptor Controls
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Prostaglandin Receptor Ligands
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Prostaglandin Receptor Related Products (767)
Related Products (767)
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Antibodies (2)
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Prostaglandin Receptor Isoform Comparison
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Laropiprant sodium
0 ImagesCat. No.: HY-50175ACAS No.: 572874-50-1Synonyms: MK-0524 sodium
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MK-8318
0 ImagesCat. No.: HY-112604CAS No.: 1416581-40-2MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.
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ARRY-502
0 ImagesCat. No.: HY-124065CAS No.: 1202891-16-4ARRY-502 is an orally active, potent and selective CRTh2 antagonist. ARRY-502 blocks PGD2-mediated Th2 inflammation (e.g., eosinophil activation, airway hyperresponsiveness). ARRY-502 is promising for research of Th2-related asthma.
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ICI 185282
0 ImagesCat. No.: HY-101235CAS No.: 106393-80-0ICI 185282 is a potent, selective, orally active thromboxane A2 (TXA₂) receptor antagonist. ICI 185282 causes dose-dependent inhibition of U-46619 (HY-108566)-induced platelet aggregation ex-vivo in guinea-pig. ICI 185,282 inhibits bronchospasm induced by U-46619, PGD2 (HY-101988), PGF2α (HY-12956), arachidonic acid (HY-109590), LTD4 and PAF (HY-108635) in vivo. ICI 185282 can be used for bronchial asthma research.
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ACT-774312
0 ImagesCat. No.: HY-182637CAS No.: 1809863-68-0ACT-774312 is a potent and selective CRTH2 antagonist with an IC50 of 4 nM. ACT-774312 blocks the activity and internalization of the CRTH2 receptor, and inhibits PGD2-induced morphological changes in eosinophils. ACT-774312 can be used in the research of nasal polyps and type 2 inflammatory diseases.
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GSK345931A
0 ImagesCat. No.: HY-111258CAS No.: 869499-38-7GSK345931A is an EP1 receptor antagonist. GSK345931A shows measurable CNS penetration in the mouse and rat and potent analgesic efficacy in acute and sub-chronic models of inflammatory pain.
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MK-1029
0 ImagesCat. No.: HY-123787CAS No.: 1242273-04-6MK-1029 is a DP2 antagonist. MK-1029 can be used in research on respiratory diseases such as asthma.
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NVP-QAV680
0 ImagesCat. No.: HY-12284CAS No.: 872365-16-7NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with low nanomolar (nM) functional potency to inhibit CRTh2-driven activation of human eosinophils and Th2 lymphocytes. NVP-QAV680 exhibits good oral bioavailability and demonstrates efficacy in CRTh2-dependent mechanisms and allergic disease models in rats.
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(R)-Vorbipiprant
0 ImagesCat. No.: HY-163651CAS No.: 2502965-92-4Synonyms: (R)-CR6086(R)-Vorbipiprant ((R)-CR6086) is an orally active antagonist for prostaglandin E2 receptor 4 (EP4) with Ki of 16.6 nM for human EP4. (R)-Vorbipiprant inhibits PGE2 (HY-101952)-induced cAMP production with an IC50 of 22 nM. (R)-Vorbipiprant exhibits immunomodulatory and anti-angiogenic activities, and ameliorates the collagen-induced arthritis in mice.
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TGI-15
0 ImagesCat. No.: HY-178792CAS No.: 3073601-32-5TGI-15 is a highly selective prostaglandin F receptor antagonist. TGI-15 inhibits downstream signaling pathways by blocking the binding of PGF2 α to FP receptors. TGI-15 can be used for research on fibrotic and inflammatory conditions.
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EP1 receptor antagonist-1
0 ImagesCat. No.: HY-177544CAS No.: 330795-70-5EP1 receptor antagonist-1 (Compound Example 5a freebase) is an EP1 prostaglandin receptor antagonist. EP1 receptor antagonist-1 is promising for research of urinary system-related diseases.
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ASP7657 free base
0 ImagesASP7657 free base is an orally active EP4 receptor antagonist, with Kis of 2.21 and 6.02 nM for the human and rat EP4 receptors.
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(S)-Trimetoquinol hydrochloride
0 ImagesCat. No.: HY-108282CAS No.: 18559-59-6Synonyms: (S)-AQL 208 hydrochloride; (S)-TMQ hydrochloride(S)-Trimetoquinol hydrochloride (Compound 1) is a apotent, nonselective, nonclassical β-adrenergic agonist and nonprostanoid thromboxane A2/prostaglandin H2 antagonist. (S)-Trimetoquinol hydrochloride can be used for research of neurological and cardiovascular disease.
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CGS-22652
0 ImagesCat. No.: HY-19132CAS No.: 134235-78-2CGS 22652 is a potent thromboxane A2 receptor antagonist. CGS 22652 has selective thromboxane A2 synthase inhibitory properties. CGS 22652 can be used in the research of coronary artery thrombosis.
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I-SAP
0 ImagesCat. No.: HY-118044CAS No.: 133538-58-6I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC).
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AH22921
0 ImagesCat. No.: HY-115827CAS No.: 74480-23-2AH22921 is an EP4 prostaglandin receptor antagonist with the activity of antagonizing the activation of adenylate cyclase by prostaglandins in CHO cells. AH22921 can shift the PGE2 concentration-response curve to the right in CHO cells. It is a non-competitive antagonist that is selective for EP4 receptors and has an antagonistic effect on EP4 receptors in CHO cells, but does not affect the PGE2 concentration-response curve in NPE cells containing EP2 receptors.
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MF266-1
0 ImagesCat. No.: HY-111304CAS No.: 848188-18-1MF266-1 is a selective E prostanoid receptor 1 (EP1) antagonist with an Ki value of 3.8 nM. MF266-1 also has moderate selectivity for thromboxane A2 receptor (TP). MF266-1 is promising for research of arthritis.
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KF15766
0 ImagesCat. No.: HY-100570CAS No.: 124907-44-4KF15766 (compd 34E) is an orally active TXA2 and H1 dual antagonist with Kis of 740 and 20 nM. KF15766 can be used for antiallergic research.
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Domitroban
0 ImagesCat. No.: HY-106891CAS No.: 112966-96-8Domitroban is a thromboxane A2 receptor (TBXA2R) antagonist. Domitroban can inhibit platelet aggregation. Domitroban can be used for the research of cardiovascular disease, such as thrombosis.
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EP3 antagonist 4
0 ImagesCat. No.: HY-153256CAS No.: 2408297-80-1EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes.
