1. Epigenetics
  2. Histone Methyltransferase

UNC1215 

Cat. No.: HY-15649 Purity: 98.39%
Handling Instructions

UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM.

For research use only. We do not sell to patients.

UNC1215 Chemical Structure

UNC1215 Chemical Structure

CAS No. : 1415800-43-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
50 mg USD 617 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM. IC50 Value: 120 nM (Kd) [1] Target: L3MBTL3 In vitro: UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2:2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization [1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 270 mg/mL (509.70 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8878 mL 9.4389 mL 18.8779 mL
5 mM 0.3776 mL 1.8878 mL 3.7756 mL
10 mM 0.1888 mL 0.9439 mL 1.8878 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

529.72

Formula

C₃₂H₄₃N₅O₂

CAS No.

1415800-43-9

SMILES

O=C(C1=CC=C(C(N2CCC(N3CCCC3)CC2)=O)C=C1NC4=CC=CC=C4)N5CCC(N6CCCC6)CC5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
UNC1215
Cat. No.:
HY-15649
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UNC1215

Cat. No.: HY-15649