Art. -Nr.: HY-B0030

D-Cycloserine

7 Cited Publications

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Based on 7 publication(s) in Google Scholar

D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes, with blood-brain barrier permeability. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research.

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Reinheit: 99.73%
CAS. Nr.: 68-41-7
Formel: C₃H₆N₂O₂
Molecular Weight:102.09

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

D-Cycloserine Chemical Structure

CAS. Nr.: 68-41-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
- Clinical Trial
Chemical Information
Publications (7)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

NMDA Receptor

Alle iGluR Isoform-spezifische Produkte anzeigen :

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	IC₅₀	>1000 μM Compound: Cycloserine	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	>1000 μM Compound: Cycloserine	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Vero	IC₅₀	>62.5 μg/mL Compound: Cycloserine	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23352268]
Vero	IC₅₀	>100 μg/mL Compound: Cycloserine	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay	[PMID: 24087924]
Vero	IC₅₀	>6.25 μg/mL Compound: Cycloserine	Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 28552337]

In Vivo

D-Cycloserine selectively potentiates the duration of motor cortical excitability enhancements induced by anodal transcranial direct current (tDCS). D-Cycloserine alone does not modulate excitability. ^[1].
Chronic D-Cycloserine (40 mg/kg; 5 days/week; for 2 weeks) significantly reduces nicotine self-administration selectively in rats with low baseline nicotine use, but is ineffective with the rats with higher levels of baseline nicotine self-administration^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 68-41-7
Appearance Solid
Molecular Weight 102.09
Formel C₃H₆N₂O₂
Color White to off-white
SMILES

O=C1[C@H](N)CON1
Structure Classification
- Antibiotics
- Other Antibiotics
- Antibiotics
- Resistance Selection
Initial Source
- Microorganisms
Streptomyces
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (7)

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Journal Impact Factor

mLife

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria. [Abstract]

2025 Apr 15;4(2):155-168. PMID: 40313980
J Affect Disord

Enriched environment prevented glutamate receptor loss in the prefrontal cortex to alleviate CUMS-induced depression-like behaviors. [Abstract]

2026 Feb 15;395(Pt A):120634. PMID: 41237964
Molecules

Identification of Marrubiin as a Cathepsin C Inhibitor for Treating Rheumatoid Arthritis. [Abstract]

2025 Oct 23;30(21):4170. PMID: 41226133
ACS Chem Biol

Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]

2022 Jan 21;17(1):39-53. PMID: 34908399
Biochem Biophys Res Commun

AMPA receptor potentiation alleviates NLRP3 knockout-induced fear generalization in mice. [Abstract]

2024 May 23:722:150074. PMID: 38805785
Exp Brain Res

The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults. [Abstract]

2023 Dec;241(11-12):2735-2750. PMID: 37845379
Research Square Preprint

2021 Aug.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 12.5 mg/mL (122.44 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1 mg/mL (9.80 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

9.7953 mL

48.9764 mL

97.9528 mL

5 mM

1.9591 mL

9.7953 mL

19.5906 mL

10 mM

0.9795 mL

4.8976 mL

9.7953 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 11.11 mg/mL (108.83 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nitsche, M.A., et al., Consolidation of human motor cortical neuroplasticity by D-cycloserine. Neuropsychopharmacology, 2004. 29(8): p. 1573-8. [Content Brief]

[2]. Sarah Batson, et al. Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nat Commun. 2017 Dec 5;8(1):1939. [Content Brief]

[3]. Levin, E.D., et al., D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response. Pharmacol Biochem Behav, 2011. 98(2): p. 210-4. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	9.7953 mL	48.9764 mL	97.9528 mL	244.8820 mL
DMSO / H₂O	5 mM	1.9591 mL	9.7953 mL	19.5906 mL	48.9764 mL
H₂O	10 mM	0.9795 mL	4.8976 mL	9.7953 mL	24.4882 mL
	15 mM	0.6530 mL	3.2651 mL	6.5302 mL	16.3255 mL
	20 mM	0.4898 mL	2.4488 mL	4.8976 mL	12.2441 mL
	25 mM	0.3918 mL	1.9591 mL	3.9181 mL	9.7953 mL
	30 mM	0.3265 mL	1.6325 mL	3.2651 mL	8.1627 mL
	40 mM	0.2449 mL	1.2244 mL	2.4488 mL	6.1220 mL
	50 mM	0.1959 mL	0.9795 mL	1.9591 mL	4.8976 mL
	60 mM	0.1633 mL	0.8163 mL	1.6325 mL	4.0814 mL
	80 mM	0.1224 mL	0.6122 mL	1.2244 mL	3.0610 mL
	100 mM	0.0980 mL	0.4898 mL	0.9795 mL	2.4488 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

D-Cycloserine

7 Cited Publications

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D-Cycloserine

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Publications Citing Use of MedChemExpress (MCE) D-Cycloserine

Alle iGluR Isoform-spezifische Produkte anzeigen

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

D-Cycloserine Related Classifications

HY-B0030 Related Classifications