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Art. -Nr.: HY-P11915

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GG13

GG13 is an anti-inflammatory peptide. GG13 reduces the expression of STAT1, NOS2, COX2, and CD40. GG13 decreases the expression and secretion of iNOS and TNF-α proteins. GG13 is applicable to the research of inflammatory diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₄₈H₇₆N₁₆O₁₇
Molecular Weight:1149.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

GG13 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

COX-2

STAT1

iNOS

NOS2

Alle STAT Isoform-spezifische Produkte anzeigen :

Alle NO Synthase Isoform-spezifische Produkte anzeigen :

Alle COX Isoform-spezifische Produkte anzeigen :

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

GG13 (25-400 μg/mL; 20 h) promotes the proliferation of RAW264.7 macrophages without reducing cell viability^[1].
GG13 (50-400 μg/mL; 12 h) inhibits LPS-stimulated NO production in RAW264.7 macrophages in a concentration-dependent manner, with an inhibition rate of 68.81% at 200 μg/mL and 73.53% at 400 μg/mL^[1].
GG13 downregulates the expression of key pro-inflammatory proteins STAT1, NOS2, COX2 and CD40 in LPS-stimulated RAW264.7 macrophages, a finding confirmed by label-free proteomic analysis^[1].
GG13 (50-200 μg/mL; 12 h) inhibits TNF-α secretion in LPS-stimulated RAW264.7 macrophages in a concentration-dependent manner, with an inhibition rate of 40.25% at the concentration of 200 μg/mL^[1].
GG13 (50-200 μg/mL; 12 h) reduces the expression of pro-inflammatory iNOS and TNF-α proteins in LPS-stimulated RAW264.7 macrophages in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RAW264.7 macrophages
Concentration:

25-400 μg/mL
Incubation Time:

20 h
Result:

Enhanced cell proliferation across all tested concentrations without significantly affecting cell viability, relative to untreated control cells.

ELISA Assay^[1]

Cell Line:

LPS-stimulated RAW264.7 macrophages
Concentration:

50-200 μg/mL
Incubation Time:

12 h pre-incubation, followed by 8 h LPS co-incubation
Result:

Inhibited TNF-α secretion in a concentration-dependent manner (p < 0.001).
Reduced TNF-α secretion by 40.25% at 200 μg/mL.

Western Blot Analysis^[1]

Cell Line:

LPS-stimulated RAW264.7 macrophages
Concentration:

50-200 μg/mL
Incubation Time:

12 h pre-incubation, followed by 8 h LPS co-incubation
Result:

Reduced the expression of iNOS and TNF-α proteins significantly in a concentration-dependent manner (p < 0.01).

Chemical Information

Molecular Weight 1149.21
Formel C₄₈H₇₆N₁₆O₁₇
Sequence

Gly-Pro-Gly-Ala-Pro-Ala-Asp-Pro-Gly-Arg-Pro-Thr-Gly
Sequence Shortening

GPGAPADPGRPTG
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zheng W, et al. Identification of a novel peptide with anti-inflammatory activity from Binglangjiang buffalo fermented milk and its potential inhibitory mechanism in lipopolysaccharide-stimulated RAW264.7 cells. Food chemistry. 2025 Mar 15;468:142451.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

GG13

Alle STAT Isoform-spezifische Produkte anzeigen

Alle NO Synthase Isoform-spezifische Produkte anzeigen

Alle COX Isoform-spezifische Produkte anzeigen

Alle TNF Receptor Isoform-spezifische Produkte anzeigen