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K-41

K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity.

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CAS. Nr.: 53026-37-2
Formel: C₄₈H₈₂O₁₈
Molecular Weight:947.15

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

K-41 Chemical Structure

CAS. Nr.: 53026-37-2

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity^[1]^[2].

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In Vitro

K-41 inhibits K1 and FCR3 strains of Plasmodium falciparum, with IC₅₀s of 8.5 and 31 nM^[1].
K-41 inhibits B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumonia, C. diphtheria, and M. tuberculosis, with MICs of 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/mL, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

K-41 (p.o.) inhibits P. berghei and P. yoelii infection in mice, with ED₅₀s of 1.9 and 7.0 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 53026-37-2
Molecular Weight 947.15
Formel C₄₈H₈₂O₁₈
SMILES

C[C@H]([C@H]1OC)[C@](O[C@@H](C2)C[C@H](O[C@]3(O)[C@@H](O)C(O)=O)[C@@](C)([C@H]([C@@H]3C)OC)OC)([C@@H]([C@@H]2OC)C)O[C@@]1([C@]4([H])O[C@@]([C@]5([H])O[C@]([C@](O[C@@]6(O)C)([H])[C@H]([C@@H]([C@H]6C)O[C@@H](CC[C@@H]7OC)O[C@@H]7C)C)([H])CC5)([H])CC4)C
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
germ
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Otoguro K, et al. In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia. J Antibiot (Tokyo). 2002 Sep;55(9):832-4. [Content Brief]

[2]. Tsuji N, et al. Two new antibiotics, A-218 and K-41. Isolation and characterization. J Antibiot (Tokyo). 1976 Jan;29(1):10-4. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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K-41

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