KH-259
KH-259 (compound 1) is a potent, selective and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain. KH-259 can be used for neurodegenerative diseases research.
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- CAS. Nr.: 3023019-93-1
- Formel: C20H25N3O2
- Molecular Weight:339.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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HDAC6 0.26 ± 0.2 μM (IC50) |
HDAC1 6.7 ± 0.14 μM (IC50) |
HDAC4 12.3 ± 0.4 μM (IC50) |
KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3023019-93-1
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Molecular Weight 339.43
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Formel C20H25N3O2
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SMILES
CC(N1CCN(CC2=CC=C(C(NO)=O)C=C2)CC1)C3=CC=CC=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KH-259 Related Classifications
HY-150503 Related Classifications
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