OM-1700
OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM).
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- CAS. Nr.: 2406276-78-4
- Formel: C25H23FN6O2
- Molecular Weight:458.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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TNKS1 127 nM (IC50) |
TNKS2 14 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 320DM | GI50 |
650 nM
Compound: 13; OM-1700
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Antiproliferative activity against human COLO320DM cells measured after 5 days by MTS assay
Antiproliferative activity against human COLO320DM cells measured after 5 days by MTS assay
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[PMID: 32511917] |
| COLO 320DM | GI50 |
650 nM
Compound: 1; OM-1700
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Antiproliferative activity against human COLO 320DM cells assessed as growth inhibition incubated for 5 days by MTS assay
Antiproliferative activity against human COLO 320DM cells assessed as growth inhibition incubated for 5 days by MTS assay
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[PMID: 34878777] |
| HEK293 | IC50 |
19 nM
Compound: 13; OM-1700
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Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo luciferase reporter gene assay
Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo luciferase reporter gene assay
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[PMID: 32511917] |
| RKO | GI50 |
>10000 nM
Compound: 1; OM-1700
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Antiproliferative activity against human RKO cells assessed as growth inhibition incubated for 5 days by MTS assay
Antiproliferative activity against human RKO cells assessed as growth inhibition incubated for 5 days by MTS assay
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[PMID: 34878777] |
OM-153 shows inhibition (IC50=19 nM) in a cellular (HEK293) WNT/β-catenin signaling reporter assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2406276-78-4
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Molecular Weight 458.49
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Formel C25H23FN6O2
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SMILES
FC1=[C@](C=CC=C1)[N@]2C([C@]3([H])C[C@H](C3)NC(C4=CC=CC=N4)=O)=NN=C2C5=CC=C(C=N5)OCC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
OM-1700 Related Classifications
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