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Art. -Nr.: HY-151569

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SAHA-OH

SAHA-OH is a selective HDAC6 inhibitor (IC₅₀=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis.

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CAS. Nr.: 2857098-30-5
Formel: C₁₅H₂₂N₂O₄
Molecular Weight:294.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SAHA-OH Chemical Structure

CAS. Nr.: 2857098-30-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

HDAC6

23 nM (IC₅₀)

HDAC1

237 nM (IC₅₀)

HDAC3

359 nM (IC₅₀)

HDAC2

399 nM (IC₅₀)

HDAC8

1070 nM (IC₅₀)

Alle HDAC Isoform-spezifische Produkte anzeigen :

In Vitro

SAHA-OH (0.67-10.76 μM; 51 h) shows inhibition in bone marrow macrophages^[1].
SAHA-OH (0.01 μM; 3 h) treatment in BMMØs (bone marrow macrophages) reduces IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2) and GROα (CXCL1) secretions^[1].
SAHA-OH (10 μM; 4 or 9 h) treatment induces acetylation of cytoplasmic α-tubulin and nuclear histone H3^[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates macrophage apoptosis^[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates B cell death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

BMMØs (bone marrow macrophages)
Concentration:

0.67-10.76 μM
Incubation Time:

51 h
Result:

Showed IC₅₀ value in unstimulated BMMØs of 1.26 μM, and showed IC₅₀ value in LPS-stimulated BMMØs of 10.76 μM.

Apoptosis Analysis^[1]

Cell Line:

BMMØs (bone marrow macrophages)
Concentration:

0-30 μM
Incubation Time:

3 h
Result:

Resulted in a 24- to 26-fold increase in cellular viability as compared to the SAHA treatment.

Cell Cytotoxicity Assay^[1]

Cell Line:

B cells
Concentration:

0-30 μM
Incubation Time:

3 h
Result:

Resulted in a 5-fold enhancement in viability and a 3-fold decrease in cell death for the B cell population.

Western Blot Analysis^[1]

Cell Line:

BMMØs (bone marrow macrophages)
Concentration:

10 μM
Incubation Time:

4 or 9 h
Result:

Resulted in the acetylation of α-tubulin.
Induced the acetylation of histone H3 compared to no treatment (NT).

In Vivo

SAHA-OH (intraperitoneal injection; 50 mg/kg; once) treatment prevents splenic organ damage, and reduces plasma proinflammatory cytokine levels in LPS-induced endotoxemia mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS-induced endotoxemia mouse model^[1]
Dosage:

50 mg/kg
Administration:

Intraperitoneal injection; 50 mg/kg; once
Result:

Reduced proinflammatory cytokine secretions by about 50% compared to no treatment (NT) control mice.
Showed similar architecture as no treatment (NT) control and displayed well-organized lymphoid follicles.

Chemical Information

CAS. Nr. 2857098-30-5
Molecular Weight 294.35
Formel C₁₅H₂₂N₂O₄
SMILES

O=C(NO)CCCCCCC(NC1=CC=C(CO)C=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nhu Truong, et al. Modified Suberoylanilide Hydroxamic Acid Reduced Drug-Associated Immune Cell Death and Organ Damage under Lipopolysaccharide Inflammatory Challenge. ACS Pharmacol. Transl. Sci. 2022.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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SAHA-OH

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

SAHA-OH Related Classifications

HY-151569 Related Classifications