Xanthomicrol
Based on 1 Customer Validation
Xanthomicrol is extracted from the resin of the plant called Chinese bellflower (a member of the Scrophulariaceae family) and is a monoamine oxidase (MAOs) inhibitor. Xanthomicrol has anti-tumor and anti-inflammatory properties, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells. Xanthomicrol's the main metabolite of 5DT in mouse colon, and it can reduce levels of iNOS protein and mRNA, as well as COX-2 protein levels. Additionally, Xanthomicrol decreases the production of the pro-inflammatory cytokine IL-1β and induces the expression of the antioxidant enzyme HO-1.
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- Reinheit: 97.68%
- CAS. Nr.: 16545-23-6
- Formel: C18H16O7
- Molecular Weight:344.32
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Speicherung:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16-F10 | IC50 |
3.8 μM
Compound: 11
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Anti-inflammatory activity in LPS-stimulated mouse B16-F10 cells assessed as reduction in TNFalpha production measured for 12 hrs by ELISA method
Anti-inflammatory activity in LPS-stimulated mouse B16-F10 cells assessed as reduction in TNFalpha production measured for 12 hrs by ELISA method
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[PMID: 37683361] |
| THP-1 | IC50 |
8.1 μM
Compound: 11
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Anti-inflammatory activity in LPS-stimulated human THP-1 cells assessed as reduction of TNFalpha measured for 12 hrs by ELISA method
Anti-inflammatory activity in LPS-stimulated human THP-1 cells assessed as reduction of TNFalpha measured for 12 hrs by ELISA method
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[PMID: 37683361] |
Chemical Information
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CAS. Nr. 16545-23-6
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Appearance Solid
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Molecular Weight 344.32
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Formel C18H16O7
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Color Light yellow to yellow
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SMILES
COC1=C(OC)C(OC)=C2C(C(C=C(C3=CC=C(O)C=C3)O2)=O)=C1O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[2]. Fereshteh Jahaniani, et al. Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry. 2005 Jul;66(13):1581-92. [Content Brief]
[4]. Fatma Pinar Turkmenoglu, et al. Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol. Molecules. 2015 Apr 23;20(5):7454-73. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Xanthomicrol Related Classifications
HY-W419589 Related Classifications
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