BRD4 Inhibitor-38
BRD4 Inhibitor-38 (Compound 25) is an orally active inhibitor of BRD4 with IC50 values of 3.64 μM and 0.12 μM against BRD4 BD1 and BRD4 BD2, respectively. BRD4 Inhibitor-38 also exhibits anti-inflammatory activity, with an IC50 value of 1.98 μM for inhibiting nitric oxide (NO) production.
For research use only. We do not sell to patients.
- Formula: C19H18N2O4
- Molecular Weight:338.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRD4 BD1 3.64 μM (IC50) |
BRD4 BD2 0.12 μM (IC50) |
BRD4 Inhibitor-38 (Compound 25) (2.5-20 μM; 2 h) exhibits anti-inflammatory activity in Raw 264.7 and THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Raw 264.7, THP-1
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Concentration:2.5, 5, 10, 20 μM
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Incubation Time:2 h (stimulated with LPS (1 μg/mL) and LPS (100 ng/mL) + IFN-γ (20 ng/mL) for 6 h. note: Compound 25 were pre-treated for 2 h before stimulating with LPS for 6 h.)
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Result:Inhibited the mRNA expression of LPS-induced IL-6 and TNF-α in a dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-induced mouse model of acute inflammation[1].
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Dosage:25, 50, 100 mg/kg
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Administration:Oral administration (p.o.)，single dose. After LPS treatment (10mg/kg; Single dose)
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Result:Significantly inhibited the increase of inflammatory genes IL-6 and TNF-α at doses of 50 and 100 mg/kg. Alleviated lung tissue edema, damage, and lung hemorrhage. Mitigated kidney damage, significantly increased the proportion of normal renal tubules, improved the internal brush border structure, reduced renal interstitial inflammatory cell infiltration, and decreased the number of interstitial vacuoles at a dose of 100 mg/kg.
Chemical Information
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Molecular Weight 338.36
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Formula C19H18N2O4
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SMILES
COC1=C2C(N=C(/C=C/C3=CC=C(OC)C=C3)NC2=O)=CC(OC)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRD4 Inhibitor-38 Related Classifications
HY-170686 Related Classifications
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