NAB2 - NGFI-A binding protein 2 Gene

Also Known as MADER

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4665

About NAB2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,089,114-57,095,476 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 51 phenotypes. Ubiquitous expression in endometrium (RPKM 17.8), ovary (RPKM 17.7) and 25 other tissues.

Summary

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with Other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

NAB2 Products (2)

mRNA Protein Name
NM_001330305.2 NP_001317234.1 NGFI-A-binding protein 2 isoform 2
NM_005967.4 NP_005958.1 NGFI-A-binding protein 2 isoform 1
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of transcription by RNA polymerase III IDA
IDA: Inferred from direct assay
8668170 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAB2 Protein Structure

NCD1

NCD1: NAB conserved region 1 (NCD1) (34 - 115)

NCD2

NCD2: NAB conserved region 2 (NCD2) (200 - 366)

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  • 200
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  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

NGFI-A-binding protein 2

  • EGR1 binding protein 2

NAB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NAB2 Q15742 KRTAP10-8 Homo sapiens P60410 25416956
Intra
NAB2 Q15742 KRTAP10-8 Homo sapiens P60410 25416956
Intra
NAB2 Q15742 CCHCR1 Homo sapiens Q8TD31-3 25416956
Intra
NAB2 Q15742 CCHCR1 Homo sapiens Q8TD31-3 25416956
Intra
NAB2 Q15742 CCHCR1 Homo sapiens Q8TD31-3 25416956
Intra
NAB2 Q15742 SUMO1P1 Homo sapiens G2XKQ0 25416956
Intra
NAB2 Q15742 TSGA10IP Homo sapiens Q3SY00 32296183
Intra
NAB2 Q15742 NDOR1 Homo sapiens Q9UHB4 32296183
Intra
NAB2 Q15742 MORF4L1 Homo sapiens Q9UBU8-2 32296183
Intra
NAB2 Q15742 KRT34 Homo sapiens O76011 32296183
Intra
NAB2 Q15742 KRT34 Homo sapiens O76011 32296183
Intra
NAB2 Q15742 CCDC57 Homo sapiens Q2TAC2-2 32296183
Intra
NAB2 Q15742 UTP14C Homo sapiens Q5TAP6 32296183
Intra
NAB2 Q15742 CTAG1A Homo sapiens P78358 32296183
Intra
NAB2 Q15742 CTAG1A Homo sapiens P78358 32296183
Intra
NAB2 Q15742 TCEANC Homo sapiens Q8N8B7-2 32296183
Intra
NAB2 Q15742 CTNNA3 Homo sapiens Q9UI47-2 32296183
Intra
NAB2 Q15742 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
NAB2 Q15742 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
NAB2 Q15742 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
NAB2 Q15742 KIFC3 Homo sapiens Q9BVG8-5 32296183
Intra
NAB2 Q15742 MGC50722 Homo sapiens Q8IVT4 32296183
Intra
NAB2 Q15742 ANKRD11 Homo sapiens X5D778 32296183
Intra
NAB2 Q15742 NEDD9 Homo sapiens Q14511 25416956
Intra
NAB2 Q15742 NEDD9 Homo sapiens Q14511 25416956
Intra
NAB2 Q15742 ZMAT2 Homo sapiens Q96NC0 32296183
Intra
NAB2 Q15742 PHOSPHO2 Homo sapiens Q8TCD6 25416956
Intra
NAB2 Q15742 PHOSPHO2 Homo sapiens Q8TCD6 25416956
Intra
NAB2 Q15742 PHOSPHO2 Homo sapiens Q8TCD6 32296183
Intra
NAB2 Q15742 PHOSPHO2 Homo sapiens Q8TCD6 25416956
Intra
NAB2 Q15742 MCRS1 Homo sapiens Q96EZ8 32296183
Intra
NAB2 Q15742 TRAF2 Homo sapiens Q12933 32296183
Intra
NAB2 Q15742 TRAF2 Homo sapiens Q12933 32296183
Intra
NAB2 Q15742 MCM7 Homo sapiens P33993 25416956
Intra
NAB2 Q15742 MCM7 Homo sapiens P33993 25416956
Intra
NAB2 Q15742 SMARCD1 Homo sapiens Q96GM5 32296183
Intra
NAB2 Q15742 CDC23 Homo sapiens Q9UJX2 32296183
Intra
NAB2 Q15742 MORF4L1 Homo sapiens Q9UBU8 25416956
Intra
NAB2 Q15742 MORF4L1 Homo sapiens Q9UBU8 25416956
Intra
NAB2 Q15742 MORF4L1 Homo sapiens Q9UBU8 25416956
Intra
NAB2 Q15742 PHF1 Homo sapiens O43189 31515488
Intra
NAB2 Q15742 PHF1 Homo sapiens O43189 25416956
Intra
NAB2 Q15742 PHF1 Homo sapiens O43189 25416956
Intra
NAB2 Q15742 PHF1 Homo sapiens O43189 25416956
Intra
NAB2 Q15742 CWF19L2 Homo sapiens Q2TBE0 25416956
Intra
NAB2 Q15742 CWF19L2 Homo sapiens Q2TBE0 32296183
Intra
NAB2 Q15742 CWF19L2 Homo sapiens Q2TBE0 25416956
Intra
NAB2 Q15742 GOLGA6L9 Homo sapiens A6NEM1 32296183
Intra
NAB2 Q15742 GOLGA6L9 Homo sapiens A6NEM1 32296183
Intra
NAB2 Q15742 RFC5 Homo sapiens P40937 29892012
Intra
NAB2 Q15742 RFC5 Homo sapiens P40937 31515488
Intra
NAB2 Q15742 RFC5 Homo sapiens P40937 25416956
Intra
NAB2 Q15742 CBX8 Homo sapiens Q9HC52 32296183
Intra
NAB2 Q15742 PIN1 Homo sapiens Q13526 25416956
Intra
NAB2 Q15742 PIN1 Homo sapiens Q13526 25416956
Intra
NAB2 Q15742 TLE5 Homo sapiens Q08117 25416956
Intra
NAB2 Q15742 FAM200C Homo sapiens Q8IZ13 31515488
Intra
NAB2 Q15742 FAM200C Homo sapiens Q8IZ13 25416956
Intra
NAB2 Q15742 FAM200C Homo sapiens Q8IZ13 32296183
Intra
NAB2 Q15742 FAM200C Homo sapiens Q8IZ13 25416956
Intra
NAB2 Q15742 FAM200C Homo sapiens Q8IZ13 25416956
Intra
NAB2 Q15742 LENG1 Homo sapiens Q96BZ8 25416956
Intra
NAB2 Q15742 LENG1 Homo sapiens Q96BZ8 32296183
Intra
NAB2 Q15742 RINT1 Homo sapiens Q6NUQ1 32296183
Intra
NAB2 Q15742 RINT1 Homo sapiens Q6NUQ1 32296183
Intra
NAB2 Q15742 RINT1 Homo sapiens Q6NUQ1 32296183
Intra
NAB2 Q15742 LNX1 Homo sapiens Q8TBB1 32296183
Intra
NAB2 Q15742 TRIM23 Homo sapiens P36406 32296183
Intra
NAB2 Q15742 TRIM23 Homo sapiens P36406 32296183
Intra
NAB2 Q15742 ZNF417 Homo sapiens Q8TAU3 32296183
Intra
NAB2 Q15742 TCHP Homo sapiens Q9BT92 31515488
Intra
NAB2 Q15742 TCHP Homo sapiens Q9BT92 32296183
Intra
NAB2 Q15742 NTAQ1 Homo sapiens Q96HA8 32296183
Intra
NAB2 Q15742 SORBS3 Homo sapiens O60504 32296183
Intra
NAB2 Q15742 SORBS3 Homo sapiens O60504 32296183
Intra
NAB2 Q15742 EXOC8 Homo sapiens Q8IYI6 32296183
Intra
NAB2 Q15742 SPG21 Homo sapiens Q9NZD8 32296183
Intra
NAB2 Q15742 DGCR6L Homo sapiens Q9BY27 32296183
Intra
NAB2 Q15742 ENKD1 Homo sapiens Q9H0I2 32296183
Intra
NAB2 Q15742 NME7 Homo sapiens Q9Y5B8 32296183
Intra
NAB2 Q15742 NME7 Homo sapiens Q9Y5B8 25416956
Intra
NAB2 Q15742 NME7 Homo sapiens Q9Y5B8 25416956
Intra
NAB2 Q15742 NME7 Homo sapiens Q9Y5B8 25416956
Intra
NAB2 Q15742 TSGA10 Homo sapiens Q9BZW7 32296183
Intra
NAB2 Q15742 GCC1 Homo sapiens Q96CN9 25416956
Intra
NAB2 Q15742 ZMYND19 Homo sapiens Q96E35 25416956
Intra
NAB2 Q15742 ZMYND19 Homo sapiens Q96E35 32296183
Intra
NAB2 Q15742 SCNM1 Homo sapiens Q9BWG6 25416956
Intra
NAB2 Q15742 SCNM1 Homo sapiens Q9BWG6 25416956
Intra
NAB2 Q15742 JAKMIP2 Homo sapiens Q96AA8 25416956
Intra
NAB2 Q15742 JAKMIP2 Homo sapiens Q96AA8 25416956
Intra
NAB2 Q15742 PIK3R3 Homo sapiens Q92569 32296183
Intra
NAB2 Q15742 TGIF2LY Homo sapiens Q8IUE0 32296183
Intra
NAB2 Q15742 FAM9A Homo sapiens Q8IZU1 32296183
Intra
NAB2 Q15742 FAM9A Homo sapiens Q8IZU1 32296183
Intra
NAB2 Q15742 FAM9A Homo sapiens Q8IZU1 32296183
Intra
NAB2 Q15742 KIF9 Homo sapiens Q9HAQ2 32296183
Intra
NAB2 Q15742 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
NAB2 Q15742 TTC19 Homo sapiens Q6DKK2 25416956
Intra
NAB2 Q15742 TCEANC Homo sapiens Q8N8B7 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Solitary Fibrous Tumor/Hemangiopericytoma
  • Sft/Hpc

Meninges Hemangiopericytoma
  • Hemangiopericytoma Of Meninges

  • Meningeal Hemangiopericytoma

Thymus Sarcomatoid Carcinoma
  • Thymic Carcinosarcoma

  • Thymic Sarcomatoid Carcinoma

Benign Pleural Mesothelioma
  • Mesothelioma Of Pleura

  • Benign Neoplasm Of Mesothelial Tissue Of Pleura

  • Pleural Malignant Mesothelioma

Spindle Cell Lipoma
Potter'S Syndrome
  • Potter Sequence

  • Potter Syndrome

  • Oligohydramnios Sequence

  • Congenital Absence Of Kidneys Syndrome

Perivascular Tumor
  • Malignant Perivascular Cancer

Hemangiopericytoma, Malignant
  • Hemangiopericytoma

  • Haemangiopericytic Meningioma

  • Malignant Hemangiopericytoma

  • Solitary Fibrous Tumor

Secondary Hypertrophic Osteoarthropathy
  • Osteoarthropathy, Secondary Hypertrophic

  • Bamberger-Marie Disease

  • Hpoa - Hypertrophic Pulmonary Osteoarthropathy

  • Hypertrophic Pulmonary Osteoarthropathy

  • Marie Bamberger Disease

Fibrous Meningioma
  • Fibroblastic Meningioma

Benign Fibrous Mesothelioma
  • Fibrous Mesothelioma, Benign

  • Localized Benign Fibrous Mesothelioma

  • Solitary Fibrous Tumor, Pleural

  • Pleural Solitary Fibrous Tumor

  • Solitary Fibrous Tumor

Mediastinal Mesenchymal Tumor
  • Mediastinal Mesenchymal Tumour

  • Soft Tissue Tumor Of Mediastinum

  • Soft Tissue Tumour Of Mediastinum

Pericytoma With T(7;12)
Mesenchymal Cell Neoplasm
  • Benign Miscellaneous Mesenchymal Tumor

  • Mesenchymal Tumor

  • Mesenchymal Tumors

Melanoma
  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas

Nasal Cavity Benign Neoplasm
  • Benign Nasal Cavity Neoplasm

  • Neoplasm Of Nasal Cavity

  • Tumor Of The Nasal Cavity

  • Cancer Of Nasal Cavity

  • Nostril Cancer

  • Primary Malignant Neoplasm Of Nasal Cavity

  • Primary Malignant Neoplasm Of Vestibule Of Nose

Vascular Cancer
  • Blood Vessel Tumors

  • Malignant Vascular Neoplasm

  • Renal Vein Leiomyosarcoma

  • Vascular Neoplasms

  • Blood Vessel Neoplasm

  • Blood Vessel Tumor

  • Blood Vessel Tumour Disorder

  • Haemangiomatous Tumour

  • Leiomyosarcoma Of The Renal Vein

  • Malignant Great Vessel Tumor

  • Malignant Tumor Of Pulmonary Artery

  • Malignant Tumor Of Pulmonary Vein

  • Malignant Vascular Tumor

  • Neoplasm Of Great Vessel

  • Pulmonary Artery Malignant Neoplasm

  • Pulmonary Vein Malignant Neoplasm

  • Vascular Tissue Neoplasm

  • Vascular Tumors

  • Blood Vessel Cancer

  • Neoplasms, Vascular Tissue

  • Malignant Neoplasm Of Great Vessels

Pseudosarcomatous Fibromatosis
  • Nodular Fasciitis

  • Pseudosarcomatous Fasciitis

  • Fasciitis - Nodular

  • Fasciitis Nodular

Myxofibrosarcoma
  • Fibromyxosarcoma

  • Fibromyxoid Sarcoma

  • Myxoid Malignant Fibrous Histiocytoma

  • Dermatofibrosarcoma Protuberans, Myxoid

Monophasic Synovial Sarcoma
  • Monophasic Sarcoma Of Synovium

Sarcomatoid Mesothelioma
  • Malignant Fibrous Mesothelioma

  • Spindled Mesothelioma

Dedifferentiated Liposarcoma
  • Ddls

  • Liposarcoma Dedifferentiated

  • Liposarcoma, Dedifferentiated

Spindle Cell Thymoma
  • Medullary Thymoma

  • Thymoma, Medullary

  • Thymoma, Type A

Chordoid Meningioma
  • Meningioma, Chordoid

Papillary Craniopharyngioma
  • Craniopharyngioma, Papillary

  • Papillary Rathke'S Pouch Tumor

  • Craniopharyngioma Papillary

Dermatofibrosarcoma Protuberans
  • DFSP

  • Dermatofibrosarcoma

  • Giant Cell Fibroblastoma

  • Metastatic Dermatofibrosarcoma Protuberans

  • Familial Dermatofibrosarcoma Protuberans

  • Darier-Ferrand Tumor

  • Darier-Hoffmann Tumor

Synovium Cancer
  • Malignant Tumor Of Synovium

  • Synovial Neoplasm

Lipomatosis, Multiple
  • Lipoma

  • Familial Multiple Lipomatosis

  • Lipomatosis, Familial Multiple

  • Benign Lipomatous Tumor

  • Lipomatous Neoplasm

  • Multiple Lipomatosis

  • Fml

  • Lipo

  • Benign Tumor Of Adipose Tissue

  • Lipomatous Tumor

  • Tumor Of Adipose Tissue

  • Neoplasms, Adipose Tissue

  • Lipomas

Well-Differentiated Liposarcoma
  • Atypical Lipomatous Tumor

  • Atypical Lipoma

  • Alt

  • Wdls

  • Liposarcoma, Well Differentiated

  • Pleomorphic Lipoma

Infantile Myofibromatosis
  • Lipofibromatosis

  • Myofibromatosis

Hypertrophic Neuropathy Of Dejerine-Sottas
  • Dejerine-Sottas Disease

  • Dejerine-Sottas Syndrome

  • Charcot-Marie-Tooth Disease Type 3

  • DSS

  • Hereditary Motor And Sensory Neuropathy Type Iii

  • Hmsn3

  • Dejerine-Sottas Neuropathy

  • Hmsn Iii

  • Charcot-Marie-Tooth Disease, Type 3

  • Cmt3

  • Dsn

  • Hmsn 3

  • Hereditary Motor And Sensory Neuropathy Type 3

  • Hereditary Motor And Sensory Neuropathy 3

  • Hypertrophic Neuropathy Of Infancy

  • Charcot-Marie-Tooth Disease Demyelinating Type 4f

  • Charcot-Marie-Tooth Disease Type 4f

  • Charcot-Marie-Tooth Neuropathy Type 4f

  • Cmt4f

  • Hereditary Motor And Sensory Neuropathy Iii

  • Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive
  • Charcot-Marie-Tooth Disease Type 4

  • Charcot-Marie-Tooth Disease Type 4e

  • Hereditary Motor And Sensory Neuropathy

  • Cmt4e

  • CHN1

  • Hypomyelinating Neuropathy, Congenital, 1

  • Charcot-Marie-Tooth Neuropathy Type 4e

  • Neuropathy, Congenital Hypomyelinating, 1

  • Ar-Cmt1

  • Autosomal Recessive Demyelinating Charcot-Marie-Tooth

  • Cmt4

  • Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive

  • Hypomyelination, Severe Congenital

  • Charcot-Marie-Tooth Disease, Type 4e

  • Charcot-Marie-Tooth Neuropathy, Type 4e

  • Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy

  • Autosomal Recessive Congenital Hypomyelinating Neuropathy

  • Congenital Amyelinating Neuropathy

  • Congenital Hypomyelinating Neuropathy Autosomal Recessive

  • Neuropathy, Congenital Hypomyelinating Or Amyelinating

  • Severe Congenital Hypomyelination

  • Hereditary Sensory Motor Neuropathy

  • Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive

  • Neuropathy, Hypomyelinating, Congenital, Type 1

  • Neuropathy, Motor And Sensory, Hereditary

  • Congenital Hypomyelinating Neuropathy

  • Hereditary Motor And Sensory Neuropathies

  • Hereditary Sensorimotor Neuropathy

  • Hmsn - [Hereditary Motor And Sensory Neuropathy]

  • Hsmn - [Hereditary Sensory And Motor Neuropathy]

  • Hereditary Motor And Sensory Neuropathy, Types I-Iv

Myxoid Liposarcoma
  • Myxoid/Round Cell Liposarcoma

  • Liposarcoma, Myxoid

  • Mrcls

  • Myxoliposarcoma

  • MXLIPO

  • Liposarcoma Myxoid

  • Liposarcoma

Sarcoma, Synovial
  • Synovial Sarcoma

  • Synovialosarcoma

  • Synovial Cell Sarcoma

  • Sarcoma Synovial

Inflammatory Myofibroblastic Tumor
  • Inflammatory Fibrosarcoma

Prostate Cancer
  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer

Meningioma, Familial
  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris NAB2 VGNC VGNC:43601
Macaca mulatta NAB2 VGNC VGNC:75125
Bos taurus NAB2 VGNC VGNC:31858
Felis catus NAB2 VGNC VGNC:68409
Mus musculus NAB2 MGD MGI:107563
Rattus norvegicus NAB2 RGD RGD:1311712
Others NAB2 NCBI