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Cat. No.: HY-121081

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BAY-958

BAY-958 is a potent PTEFb/CDK9 inhibitor with high selectivity demonstrated, particularly within the CDK family. BAY-958 shows strong antiproliferative activity against cancer cell lines such as HeLa and MOLM-13. BAY-958 exhibits good metabolic stability. BAY-958 effectively inhibits tumor growth in mouse xenograft models without significant toxicity.

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CAS No.: 1335490-39-5
Formule: C₁₇H₁₆FN₅O₃S
Masse moléculaire:389.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BAY-958 Chemical Structure

CAS No.: 1335490-39-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform CDK :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	1 μM Compound: 40	Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining method Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining method	[PMID: 32866383]
HeLa	IC₅₀	1 μM Compound: 49; BAY-958	Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay	[PMID: 32870008]
MOLM-13	IC₅₀	280 nM Compound: 40	Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining method Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining method	[PMID: 32866383]
MOLM-13	IC₅₀	280 nM Compound: 49; BAY-958	Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining assay Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining assay	[PMID: 32870008]

Chemical Information

CAS No. 1335490-39-5
Masse moléculaire 389.40
Formule C₁₇H₁₆FN₅O₃S
SMILES

O=S(CC1=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1)(N)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Identification of atuveciclib (BAY 1143572), the first highly selective, clinical PTEFb/CDK9 inhibitor for the treatment of cancer

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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