CBP-IN-1
CBP-IN-1 is a potent CBP inhibitor with an IC50 of 1.5 nM. CBP-IN-1 also inhibits CBP BRET and BRD4 (1), with IC50 values of 690 nM and 3100 nM, respectively. CBP-IN-1 can be used in oncology and immuno-oncology research.
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- CAS No.: 1936431-44-5
- Formule: C27H33F2N7O
- Masse moléculaire:509.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
690 nM
Compound: 12
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Inhibition of Halo-tagged histone H3.3 binding to NanoLuc luciferase conjugated human CBP expressed in HEK293 cells after overnight incubation by BRET assay
Inhibition of Halo-tagged histone H3.3 binding to NanoLuc luciferase conjugated human CBP expressed in HEK293 cells after overnight incubation by BRET assay
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[PMID: 28892380] |
CBP-IN-1 (Compound 12) exhibits low predicted hepatic clearance in mouse, rat, and human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1936431-44-5
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Masse moléculaire 509.59
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Formule C27H33F2N7O
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SMILES
O=C(C)N1CC2=C(CC1)N(C3CCNCC3)N=C2N4C5=C(CCC4)C=C(C6=CN(C)N=C6)C(C(F)F)=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CBP-IN-1 Related Classifications
HY-153948 Related Classifications
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