Cat. No.: HY-A0191

Dexbrompheniramine

(Synonyms: (+)-Brompheniramine; (S)-Brompheniramine)

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Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine can be used in the research of chronic cough and related pathological mechanisms.

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Pureté: 99.93%
CAS No.: 132-21-8
Formule: C₁₆H₁₉BrN₂
Masse moléculaire:319.24

Stockage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Dexbrompheniramine Chemical Structure

CAS No.: 132-21-8

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

H₁ Receptor

TRPV1

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Voir tous les produits spécifiques à Isoform Histamine Receptor :

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In Vivo

Dexbrompheniramine (1 mg/kg; i.p.; single dose; co-administered with 16 mg/kg cimetidine) completely abolishes histamine-induced drinking behavior in rats, but does not alter serotonin-induced drinking behavior in rats^[1].
Dexbrompheniramine (1 mg/kg; i.p.; single administration; 10 min before the start of the test) alone does not alter prandial drinking or sham-feeding behavior in preabsorptive rats, but when co-administered with 16 mg/kg cimetidine, it completely abolishes the drinking response without affecting sham-feeding behavior^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley albino rats (male, 400-600 g, gastric cannula surgery for preabsorptive pregastric food-contingent drinking model)^[3]
Dosage:

1 mg/kg (alone); 1 mg/kg + cimetidine 16 mg/kg (combination)
Administration:

i.p.; single dose; 10 minutes before test initiation
Result:

Did not inhibit sham feeding.
Did not inhibit drinking).
Abolished sham feeding-elicited drinking when co-administered with cimetidine
Did not inhibit sham feeding when co-administered with cimetidine.

Chemical Information

CAS No. 132-21-8
Appearance Viscous Liquid
Masse moléculaire 319.24
Formule C₁₆H₁₉BrN₂
Color Colorless to light brown
SMILES

CN(C)CC[C@H](C1=CC=CC=N1)C2=CC=C(C=C2)Br
Synonyms

(+)-Brompheniramine; (S)-Brompheniramine
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (313.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1324 mL

15.6622 mL

31.3244 mL

5 mM

0.6265 mL

3.1324 mL

6.2649 mL

10 mM

0.3132 mL

1.5662 mL

3.1324 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kraly FS, et al. Histamine and serotonin independently elicit drinking in the rat. Physiol Behav. 1985;34(6):963-967. [Content Brief]

[2]. Singh U, et al. Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach[J]. Clinical and Experimental Allergy, 2025, 55(3): 247.

[3]. Kraly FS, et al. Preabsorptive pregastric vagally mediated histaminergic component of drinking elicited by eating in the rat. Behav Neurosci. 1984;98(2):349-355. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1324 mL	15.6622 mL	31.3244 mL	78.3110 mL
	5 mM	0.6265 mL	3.1324 mL	6.2649 mL	15.6622 mL
	10 mM	0.3132 mL	1.5662 mL	3.1324 mL	7.8311 mL
	15 mM	0.2088 mL	1.0441 mL	2.0883 mL	5.2207 mL
	20 mM	0.1566 mL	0.7831 mL	1.5662 mL	3.9155 mL
	25 mM	0.1253 mL	0.6265 mL	1.2530 mL	3.1324 mL
	30 mM	0.1044 mL	0.5221 mL	1.0441 mL	2.6104 mL
	40 mM	0.0783 mL	0.3916 mL	0.7831 mL	1.9578 mL
	50 mM	0.0626 mL	0.3132 mL	0.6265 mL	1.5662 mL
	60 mM	0.0522 mL	0.2610 mL	0.5221 mL	1.3052 mL
	80 mM	0.0392 mL	0.1958 mL	0.3916 mL	0.9789 mL
	100 mM	0.0313 mL	0.1566 mL	0.3132 mL	0.7831 mL

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Dexbrompheniramine

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Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Voir tous les produits spécifiques à Isoform Histamine Receptor

Voir tous les produits spécifiques à Isoform TRP Channel

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Dexbrompheniramine Related Classifications

HY-A0191 Related Classifications