NAB2 - NGFI-A binding protein 2 Gene
Also Known as MADER
Species: Homo sapiens
About NAB2
This gene has 5 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 51 phenotypes. Ubiquitous expression in endometrium (RPKM 17.8), ovary (RPKM 17.7) and 25 other tissues.
Summary
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with Other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
NAB2 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001330305.2 | NP_001317234.1 | NGFI-A-binding protein 2 isoform 2 |
| NM_005967.4 | NP_005958.1 | NGFI-A-binding protein 2 isoform 1 |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
21516116 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| acts upstream of or within negative regulation of transcription by RNA polymerase III |
IDA
IDA: Inferred from direct assay
|
8668170 | GOA |
NAB2 Protein Structure
NCD1: NAB conserved region 1 (NCD1) (34 - 115)
NCD2: NAB conserved region 2 (NCD2) (200 - 366)
- 0
- 100
- 200
- 300
- 400
- 500
- 525 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
NGFI-A-binding protein 2 |
|
NAB2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
NAB2 | Q15742 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | CCHCR1 | Homo sapiens | Q8TD31-3 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | CCHCR1 | Homo sapiens | Q8TD31-3 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | CCHCR1 | Homo sapiens | Q8TD31-3 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | SUMO1P1 | Homo sapiens | G2XKQ0 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | TSGA10IP | Homo sapiens | Q3SY00 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | NDOR1 | Homo sapiens | Q9UHB4 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | MORF4L1 | Homo sapiens | Q9UBU8-2 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | CCDC57 | Homo sapiens | Q2TAC2-2 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | UTP14C | Homo sapiens | Q5TAP6 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | CTAG1A | Homo sapiens | P78358 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | CTAG1A | Homo sapiens | P78358 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | TCEANC | Homo sapiens | Q8N8B7-2 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | CTNNA3 | Homo sapiens | Q9UI47-2 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | ZMYND12 | Homo sapiens | Q9H0C1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | ZMYND12 | Homo sapiens | Q9H0C1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | ZMYND12 | Homo sapiens | Q9H0C1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | MGC50722 | Homo sapiens | Q8IVT4 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | ANKRD11 | Homo sapiens | X5D778 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | NEDD9 | Homo sapiens | Q14511 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | NEDD9 | Homo sapiens | Q14511 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | ZMAT2 | Homo sapiens | Q96NC0 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | PHOSPHO2 | Homo sapiens | Q8TCD6 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | PHOSPHO2 | Homo sapiens | Q8TCD6 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | PHOSPHO2 | Homo sapiens | Q8TCD6 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | PHOSPHO2 | Homo sapiens | Q8TCD6 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | MCRS1 | Homo sapiens | Q96EZ8 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | MCM7 | Homo sapiens | P33993 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | MCM7 | Homo sapiens | P33993 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | SMARCD1 | Homo sapiens | Q96GM5 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | CDC23 | Homo sapiens | Q9UJX2 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | MORF4L1 | Homo sapiens | Q9UBU8 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | MORF4L1 | Homo sapiens | Q9UBU8 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | MORF4L1 | Homo sapiens | Q9UBU8 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | PHF1 | Homo sapiens | O43189 | 31515488 | |
|
Intra
|
NAB2 | Q15742 | PHF1 | Homo sapiens | O43189 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | PHF1 | Homo sapiens | O43189 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | PHF1 | Homo sapiens | O43189 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | CWF19L2 | Homo sapiens | Q2TBE0 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | CWF19L2 | Homo sapiens | Q2TBE0 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | CWF19L2 | Homo sapiens | Q2TBE0 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | GOLGA6L9 | Homo sapiens | A6NEM1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | GOLGA6L9 | Homo sapiens | A6NEM1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | RFC5 | Homo sapiens | P40937 | 29892012 | |
|
Intra
|
NAB2 | Q15742 | RFC5 | Homo sapiens | P40937 | 31515488 | |
|
Intra
|
NAB2 | Q15742 | RFC5 | Homo sapiens | P40937 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | CBX8 | Homo sapiens | Q9HC52 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | PIN1 | Homo sapiens | Q13526 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | PIN1 | Homo sapiens | Q13526 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | TLE5 | Homo sapiens | Q08117 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | FAM200C | Homo sapiens | Q8IZ13 | 31515488 | |
|
Intra
|
NAB2 | Q15742 | FAM200C | Homo sapiens | Q8IZ13 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | FAM200C | Homo sapiens | Q8IZ13 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | FAM200C | Homo sapiens | Q8IZ13 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | FAM200C | Homo sapiens | Q8IZ13 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | LENG1 | Homo sapiens | Q96BZ8 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | LENG1 | Homo sapiens | Q96BZ8 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | RINT1 | Homo sapiens | Q6NUQ1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | RINT1 | Homo sapiens | Q6NUQ1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | RINT1 | Homo sapiens | Q6NUQ1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | TRIM23 | Homo sapiens | P36406 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | TRIM23 | Homo sapiens | P36406 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | ZNF417 | Homo sapiens | Q8TAU3 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | TCHP | Homo sapiens | Q9BT92 | 31515488 | |
|
Intra
|
NAB2 | Q15742 | TCHP | Homo sapiens | Q9BT92 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | NTAQ1 | Homo sapiens | Q96HA8 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | SORBS3 | Homo sapiens | O60504 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | SORBS3 | Homo sapiens | O60504 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | EXOC8 | Homo sapiens | Q8IYI6 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | SPG21 | Homo sapiens | Q9NZD8 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | DGCR6L | Homo sapiens | Q9BY27 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | NME7 | Homo sapiens | Q9Y5B8 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | NME7 | Homo sapiens | Q9Y5B8 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | NME7 | Homo sapiens | Q9Y5B8 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | NME7 | Homo sapiens | Q9Y5B8 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | TSGA10 | Homo sapiens | Q9BZW7 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | GCC1 | Homo sapiens | Q96CN9 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | ZMYND19 | Homo sapiens | Q96E35 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | ZMYND19 | Homo sapiens | Q96E35 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | SCNM1 | Homo sapiens | Q9BWG6 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | SCNM1 | Homo sapiens | Q9BWG6 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | JAKMIP2 | Homo sapiens | Q96AA8 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | JAKMIP2 | Homo sapiens | Q96AA8 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | PIK3R3 | Homo sapiens | Q92569 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | TGIF2LY | Homo sapiens | Q8IUE0 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | FAM9A | Homo sapiens | Q8IZU1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | FAM9A | Homo sapiens | Q8IZU1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | FAM9A | Homo sapiens | Q8IZU1 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | KIF9 | Homo sapiens | Q9HAQ2 | 32296183 | |
|
Intra
|
NAB2 | Q15742 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | TTC19 | Homo sapiens | Q6DKK2 | 25416956 | |
|
Intra
|
NAB2 | Q15742 | TCEANC | Homo sapiens | Q8N8B7 | 25416956 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Solitary Fibrous Tumor/Hemangiopericytoma |
|
|
| Meninges Hemangiopericytoma |
|
|
| Thymus Sarcomatoid Carcinoma |
|
|
| Benign Pleural Mesothelioma |
|
|
| Spindle Cell Lipoma |
|
|
| Potter'S Syndrome |
|
|
| Perivascular Tumor |
|
|
| Hemangiopericytoma, Malignant |
|
|
| Secondary Hypertrophic Osteoarthropathy |
|
|
| Fibrous Meningioma |
|
|
| Benign Fibrous Mesothelioma |
|
|
| Mediastinal Mesenchymal Tumor |
|
|
| Pericytoma With T(7;12) |
|
|
| Mesenchymal Cell Neoplasm |
|
|
| Melanoma |
|
|
| Nasal Cavity Benign Neoplasm |
|
|
| Vascular Cancer |
|
|
| Pseudosarcomatous Fibromatosis |
|
|
| Myxofibrosarcoma |
|
|
| Monophasic Synovial Sarcoma |
|
|
| Sarcomatoid Mesothelioma |
|
|
| Dedifferentiated Liposarcoma |
|
|
| Spindle Cell Thymoma |
|
|
| Chordoid Meningioma |
|
|
| Papillary Craniopharyngioma |
|
|
| Dermatofibrosarcoma Protuberans |
|
|
| Synovium Cancer |
|
|
| Lipomatosis, Multiple |
|
|
| Well-Differentiated Liposarcoma |
|
|
| Infantile Myofibromatosis |
|
|
| Hypertrophic Neuropathy Of Dejerine-Sottas |
|
|
| Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive |
|
|
| Myxoid Liposarcoma |
|
|
| Sarcoma, Synovial |
|
|
| Inflammatory Myofibroblastic Tumor |
|
|
| Prostate Cancer |
|
|
| Meningioma, Familial |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | NAB2 | VGNC | VGNC:43601 |
| Macaca mulatta | NAB2 | VGNC | VGNC:75125 |
| Bos taurus | NAB2 | VGNC | VGNC:31858 |
| Felis catus | NAB2 | VGNC | VGNC:68409 |
| Mus musculus | NAB2 | MGD | MGI:107563 |
| Rattus norvegicus | NAB2 | RGD | RGD:1311712 |
| Others | NAB2 | NCBI |