SLC30A2 - solute carrier family 30 member 2 Gene

Also Known as TNZD; ZNT2; ZnT-2; PP12488

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7780

About SLC30A2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,037,252-26,046,118 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in thyroid (RPKM 19.5), kidney (RPKM 11.8) and 4 other tissues.

Summary

The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

SLC30A2 Products (2)

mRNA	Protein	Name
NM_001004434.3	NP_001004434.1	zinc transporter 2 isoform 1
NM_032513.5	NP_115902.1	zinc transporter 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	22733820	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25657003	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17349999	GOA
enables zinc:proton antiporter activity	IDA IDA: Inferred from direct assay	30893306	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in zinc export across plasma membrane	IDA IDA: Inferred from direct assay	19496757	GOA
involved in zinc ion import into lysosome	IDA IDA: Inferred from direct assay	17349999	GOA
involved in zinc ion import into lysosome	IMP IMP: Inferred from mutant phenotype	25808614	GOA
involved in zinc ion import into organelle	IDA IDA: Inferred from direct assay	21289295	GOA
involved in zinc ion import into organelle	IMP IMP: Inferred from mutant phenotype	22733820	GOA
involved in zinc ion import into secretory vesicle	IDA IDA: Inferred from direct assay	19496757	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17349999	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	19496757	GOA
located in late endosome	IDA IDA: Inferred from direct assay	17349999	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	25808614	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	21289295	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19496757	GOA
located in secretory vesicle	IDA IDA: Inferred from direct assay	19496757	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A2 Protein Structure

Cation_efflux

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
zinc transporter 2	solute carrier family 30 (zinc transporter), member 2

SLC30A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SLC30A2	Q9BRI3	ADAM33	Homo sapiens	Q08AM2	Y2H Array	25416956
Intra	SLC30A2	Q9BRI3	ADAM33	Homo sapiens	Q08AM2	Y2H Prey Pooling	25416956
Intra	SLC30A2	Q9BRI3	CCL4L1	Homo sapiens	Q8NHW4	Y2H Prey Pooling	25416956
Intra	SLC30A2	Q9BRI3	CCL4L1	Homo sapiens	Q8NHW4	Y2H Array	25416956
Intra	SLC30A2	Q9BRI3	SLC30A3	Homo sapiens	Q99726	IF	25657003
Intra	SLC30A2	Q9BRI3	SLC30A3	Homo sapiens	Q99726	Anti Tag CoIP	26728129
Intra	SLC30A2	Q9BRI3	SLC30A3	Homo sapiens	Q99726	BiFC	25657003
Intra	SLC30A2	Q9BRI3	ADAM33	Homo sapiens	Q9BZ11-2	Validated Y2H	25416956
Intra	SLC30A2	Q9BRI3	ADAM33	Homo sapiens	Q9BZ11-2	Y2H Array	25416956
Intra	SLC30A2	Q9BRI3	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	IL10RA	Homo sapiens	Q13651	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	IL10RA	Homo sapiens	Q13651	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	LYVE1	Homo sapiens	Q9Y5Y7	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	SLC30A1	Homo sapiens	Q9Y6M5	BiFC	25657003
Intra	SLC30A2	Q9BRI3	ATP13A1	Homo sapiens	Q9HD20-3	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	MS4A13	Homo sapiens	Q5J8X5	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	AQP2	Homo sapiens	P41181	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	AQP2	Homo sapiens	P41181	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	SLC30A10	Homo sapiens	Q6XR72	Anti Tag CoIP	26728129
Intra	SLC30A2	Q9BRI3	SLC30A4	Homo sapiens	O14863	BiFC	25657003
Intra	SLC30A2	Q9BRI3	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	PCNX2	Homo sapiens	A6NKB5-5	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	PCNX2	Homo sapiens	A6NKB5-5	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	TSPAN31	Homo sapiens	Q12999	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	TSPAN31	Homo sapiens	Q12999	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	SELL	Homo sapiens	P14151-2	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	SELL	Homo sapiens	P14151-2	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	TAS2R5	Homo sapiens	Q9NYW4	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	TAS2R5	Homo sapiens	Q9NYW4	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	TAS2R5	Homo sapiens	Q9NYW4	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	PLPPR1	Homo sapiens	Q8TBJ4	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	PLPPR1	Homo sapiens	Q8TBJ4	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	TNFRSF12A	Homo sapiens	Q9NP84	Y2H Prey Pooling	25416956
Intra	SLC30A2	Q9BRI3	TNFRSF12A	Homo sapiens	Q9NP84	Validated Y2H	25416956
Intra	SLC30A2	Q9BRI3	TNFRSF12A	Homo sapiens	Q9NP84	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	CCL4	Homo sapiens	P13236	Validated Y2H	25416956
Intra	SLC30A2	Q9BRI3	CCL4	Homo sapiens	P13236	Y2H Array	25416956
Intra	SLC30A2	Q9BRI3	CCL4	Homo sapiens	P13236	Y2H Array	31515488
Intra	SLC30A2	Q9BRI3	CCL4	Homo sapiens	P13236	Y2H Prey Pooling	25416956
Intra	SLC30A2	Q9BRI3	KCNN4	Homo sapiens	O15554	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	KCNN4	Homo sapiens	O15554	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	EMP3	Homo sapiens	P54852	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	PVR	Homo sapiens	P15151	Y2H Array	31515488
Intra	SLC30A2	Q9BRI3	PVR	Homo sapiens	P15151	Y2H Prey Pooling	25416956
Intra	SLC30A2	Q9BRI3	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	PVR	Homo sapiens	P15151	Validated Y2H	25416956
Intra	SLC30A2	Q9BRI3	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	CD40	Homo sapiens	P25942	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	CD40	Homo sapiens	P25942	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	SLC30A2	Q9BRI3	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	SLC30A2	Q9BRI3	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	SLC30A2	Q9BRI3	GPR161	Homo sapiens	Q8N6U8	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	GPR161	Homo sapiens	Q8N6U8	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	NDUFAF1	Homo sapiens	Q9Y375	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	NDUFAF1	Homo sapiens	Q9Y375	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	NDUFAF1	Homo sapiens	Q9Y375	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	F11R	Homo sapiens	Q9Y624	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	F11R	Homo sapiens	Q9Y624	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	F11R	Homo sapiens	Q9Y624	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25910212
Intra	SLC30A2	Q9BRI3	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25910212
Intra	SLC30A2	Q9BRI3	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	SLC30A2	Q9BRI3	KASH5	Homo sapiens	Q8N6L0	Y2H Bait-Prey Pool	25910212
Intra	SLC30A2	Q9BRI3	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	GJA5	Homo sapiens	P36382	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	GJA5	Homo sapiens	P36382	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	32296183
Intra	SLC30A2	Q9BRI3	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	EBAG9	Homo sapiens	O00559	Y2H Array	32296183
Intra	SLC30A2	Q9BRI3	EBAG9	Homo sapiens	O00559	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	FDPS	Homo sapiens	P14324	Y2H Prey Pooling	32296183
Intra	SLC30A2	Q9BRI3	FDPS	Homo sapiens	P14324	Y2H Array	32296183
Cross	SLC30A2	Q9BRI3	Tfrc	Rattus norvegicus	Q99376	Anti Tag CoIP	26728129

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Zinc Deficiency, Transient Neonatal	TNZD Zinc Deficiency, Neonatal, Due To Low Breast Milk Zinc Neonatal Zinc Deficiency Due To Low Breast Milk Zinc
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome
Hypermanganesemia With Dystonia 2	HMNDYT2 Dystonia-Parkinsonism-Hypermanganesemia Syndrome Hypermanganesemia With Dystonia, Type 2
Hypermanganesemia With Dystonia	Familial Manganese-Induced Neurotoxicity Hmndyt
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3	Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like Scd-Eds EDSSPD3 Ehlers-Danlos Syndrome Spondylodysplastic Type 3 Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome Slc39a13-Related Speds Slc39a13-Related Spondylodysplastic Eds Spondylocheirodysplastic Ehlers-Danlos Syndrome Speds-Slc39a13 Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Hypermanganesemia With Dystonia 1	Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis HMNDYT1 Hmdpc Hypermanganesemia With Dystonia Polycythemia And Cirrhosis Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Acrodermatitis
Metal Metabolism Disorder	Metal Metabolism, Inborn Errors Inborn Metal Metabolism Disorder
Menkes Disease	Copper Transport Disease Menkes Syndrome MNK Kinky Hair Disease Steely Hair Disease Menkes Kinky-Hair Syndrome Mk Steely Hair Syndrome Menkea Syndrome Md Menkes Kinky Hair Syndrome Hypocupremia, Congenital Kinky Hair Syndrome X-Linked Copper Deficiency Menkes Kinky Hair Disease
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS13180	SLC30A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC30A2	VGNC	VGNC:77452
Rattus norvegicus	SLC30A2	RGD	RGD:3707
Canis familiaris	SLC30A2	VGNC	VGNC:46347
Bos taurus	SLC30A2	VGNC	VGNC:34807
Mus musculus	SLC30A2	MGD	MGI:106637
Felis catus	SLC30A2	VGNC	VGNC:107622
Others	SLC30A2	NCBI