Grossamide
Based on 1 publication(s) in Google Scholar
Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.0%
- CAS No.: 80510-06-1
- Formule: C36H36N2O8
- Masse moléculaire:624.68
-
Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Grossamide
MoreVoir tous les produits spécifiques à Isoform TNF Receptor
More
Activité biologique
Grossamide downregulates LPS-mediated production of inflammatory molecules[1].
Grossamide (0-20 μM, 1 h) inhibits the mRNA levels of TNF-α and IL-6 in a dose-dependent manner, inhibits LPS-induced NF-κB activation, and inhibits LPS-induced TLR4 and MyD88 expression without cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:BV-2 microglia cell
-
Concentration:0, 10, 15, and 20 μM
-
Incubation Time:1 h and co-cultured with LPS (100 ng/mL) for another 6 h
-
Result:Inhibited the mRNA levels of TNF-α and IL-6 in a dose-dependent manner.
-
Cell Line:BV-2 microglia cell
-
Concentration:0, 10, 15, and 20 μM
-
Incubation Time:1 h followed by LPS (100 ng/mL) stimulation for 1 h or 24 h
-
Result:Inhibited LPS-induced phosphorylation of IκBα and significantly reduced phosphorylation of NF-κB p65 levels. Dose-dependently decreased the expression of TLR4 and MyD88.
-
Cell Line:BV-2 microglia cell
-
Concentration:0, 10, 15, and 20 μM
-
Incubation Time:1 h and co-cultured in the absence or presence of 100 ng/ mL LPS for 24 h
-
Result:Had no cytotoxicity.
Chemical Information
-
CAS No. 80510-06-1
-
Appearance Solid
-
Masse moléculaire 624.68
-
Formule C36H36N2O8
-
Color White to off-white
-
SMILES
O=C([C@H]1C2=CC(/C=C/C(NCCC(C=C3)=CC=C3O)=O)=CC(OC)=C2O[C@]1([H])C(C=C4)=CC(OC)=C4O)NCCC(C=C5)=CC=C5O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
J Comput Aided Mol Des
Integrated computational and experimental evaluation of grossamide as a natural product scaffold for dual carbohydrase inhibition in diabetes. [Abstract]2025 Nov 10;39(2):122. PMID: 41212441
Pureté et documentation
-
Fiche technique (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Grossamide Related Classifications
HY-N3979 Related Classifications
Powered by Bioz