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Cat. No.: HY-156615

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Igermetostat

Name: Igermetostat
Brand: MedChemExpress
SKU: HY-156615
Price: 960.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: XNW5004)

Igermetostat (XNW5004) is an orally active EZH2 inhibitor for research related to metastatic castration-resistant prostate cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2409538-60-7
Formule: C₃₂H₄₆N₄O₄
Masse moléculaire:550.73

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

Igermetostat Chemical Structure

CAS No.: 2409538-60-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Description
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- In Vivo
Chemical Information
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Description

Igermetostat (XNW5004) is an orally active EZH2 inhibitor for research related to metastatic castration-resistant prostate cancer^[1]^[2].

IC₅₀ & Target

^[1]

EZH2

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

In Vivo

Anti-cancer

Igermetostat (XNW5004) (800‑1600 mg; twice daily; oral, in combination with Enzalutamide (HY-70002) 160 mg once daily) exhibits antitumor efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2409538-60-7
Masse moléculaire 550.73
Formule C₃₂H₄₆N₄O₄
SMILES

O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(O[C@H]3C[C@H](N4CCCCC4)C3)=CC(N(CC)C5CCOCC5)=C2C
Synonyms

XNW5004
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chang Y, et al. A phase 1b/2 study to evaluate the safety and efficacy of igermetostat (XNW5004) in combination with enzalutamide in patients with metastatic castration‑resistant prostate cancer. Journal of Clinical Oncology. 2026;44(7_suppl):169.

[2]. Louati K, et al. The Identification by Shotgun Proteomics with High-Resolution Tandem Mass-Spectrometry of Histone Isoforms' Hypermethylation Phenotype as a Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas: Epigenetic Applications for Genotoxicity-Based Biomarkers and Cancer Therapy Targets. Journal of proteome research. 2025 Sep 05;24(9):4503-4525.

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références

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Igermetostat

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Description

IC50 & Target

In Vivo

Chemical Information

Pureté et documentation

Références

Calculators

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Igermetostat Related Classifications

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