KS0365
KS0365 is a selective TRPV3 agonist with an EC50 of 5.08 μM. KS0365 does not activate TRPV2 or TRPV4 channels. KS0365 triggers an increase in [Ca2+]i and accelerates keratinocyte migration. KS0365 can be used in studies related to impaired skin wound healing.
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- CAS No.: 1689577-22-7
- Formule: C15H19ClO
- Masse moléculaire:250.76
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Activité biologique
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TRPV3 5.08 μM (EC50) |
KS0365 (0.1-100 μM; 20 μM primary screen; 10 μM validation) potently and selectively activates recombinant mouse TRPV3 in HEKmTRPV3-CFP cells with an EC50 of 5.08 μM, inducing sustained [Ca2+]ᵢ increases without significant off-target effects at 10 μM[1].
KS0365 (0.8-12.5 μM HEK cells; 10-50 μM m308k cells; 24 h) induces TRPV3-dependent metabolic activity changes: it reduces metabolic activity in TRPV3-overexpressing HEKmTRPV3-CFP cells and causes a biphasic effect in m308k Mus musculus keratinocytes, with a TRPV3-mediated increase at 10 μM and off-target toxicity at 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEKmTRPV3-CFP cells, parental HEK293 cells, m308k mouse keratinocytes
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Concentration:0.8-12.5 μM (HEK cells); 10-50 μM (m308k cells)
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Incubation Time:24 h
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Result:Caused a concentration-dependent decrease in metabolic activity in HEKmTRPV3-CFP cells, which was reversed by co-treatment with 10 μM ruthenium red.
Showed no decrease in metabolic activity in parental HEK293 cells.
Exhibited a biphasic effect in m308k cells: 10 μM and 25 μM slightly but significantly increased metabolic activity (126.5% and 107.8% of untreated control, respectively), while 50 μM drastically decreased metabolic activity.
Inhibited the pro-metabolic effect of 10 μM KS0365 by 10 μM ruthenium red, but effects of 25 μM and 50 μM KS0365 were unaffected by ruthenium red.
Chemical Information
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CAS No. 1689577-22-7
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Masse moléculaire 250.76
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Formule C15H19ClO
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SMILES
ClC1=C(C(C)C)CCC1C2=CC(C)=CC=C2O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KS0365 Related Classifications
HY-186172 Related Classifications
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