ZYJ-34v
ZYJ-34v is an orally active histone deacetylase inhibitor. ZYJ-34v has antitumor activity.
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- CAS No.: 1450662-32-4
- Formule: C27H35N3O6
- Masse moléculaire:497.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
ZYJ-34v can inhibit HDACs. The IC50 values of MDA-MB-231, HCT116, PC-3, HepG2 and MCF-7 cells were 1.41, 0.63 and 2.62, respectively. 4.23 and 4.76 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:MDA-MB-231
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Concentration:1 μM
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Incubation Time:24 h
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Result:Inhibited deacetylation of tubulin, histone H3 and H4, and significantly induced an increase in the protein level of p21.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:a mouse MDA-MB-231 xenograft model[1]
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Dosage:90 mg/kg
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Administration:p.o.
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Result:Decreased the final tumor volume.
Chemical Information
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CAS No. 1450662-32-4
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Masse moléculaire 497.58
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Formule C27H35N3O6
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SMILES
COC(C=C1)=CC=C1NC([C@H]2N(CC3=CC(OCC(NO)=O)=CC=C3C2)C(C(CCC)CCC)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZYJ-34v Related Classifications
HY-139796 Related Classifications
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