Art. -Nr.: HY-B0215

Acetylcysteine

(Synonyms: N-Acetylcysteine; N-Acetyl-L-cysteine; NAC)

666 Cited Publications

Kundenbewertung

Based on 666 publication(s) in Google Scholar

Acetylcysteine (N-Acetylcysteine) is a mucolytic agent that can cross the blood-brain barrier, which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies.

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Reinheit: 99.86%
CAS. Nr.: 616-91-1
Formel: C₅H₉NO₃S
Molecular Weight:163.20

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Acetylcysteine Chemical Structure

CAS. Nr.: 616-91-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (666)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	EC₅₀	105.6 μM Compound: N-acetyl-L-cysteine	Hepatoprotective activity against H2O2-induced cell damage in rat hepatocyte assessed as reduction in cell growth Hepatoprotective activity against H2O2-induced cell damage in rat hepatocyte assessed as reduction in cell growth	[PMID: 29353722]
HT-22	EC₅₀	0.7 mM Compound: N-Acetylcysteine	Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay	[PMID: 32991171]
HUVEC	IC₅₀	10 mM Compound: N-acetyl cysteine	Antiinflammatory activity in HUVEC assessed as inhibition of TNFalpha-induced ICAM1 expression preincubated for 0.5 to 6 hrs followed by TNFalpha challenge measured after 4 hrs by immunostaining assay Antiinflammatory activity in HUVEC assessed as inhibition of TNFalpha-induced ICAM1 expression preincubated for 0.5 to 6 hrs followed by TNFalpha challenge measured after 4 hrs by immunostaining assay	10.1039/C0MD00262C
KB 3-1	IC₅₀	29.9 mM Compound: NAC	Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay	[PMID: 21657271]
KB-V1	IC₅₀	28.8 mM Compound: NAC	Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay	[PMID: 21657271]
SH-SY5Y	EC₅₀	1.68 mM Compound: NAC	Neuroprotection against H2O2-induced cell death in human SH-SY5Y cells preincubated for 6 hrs followed by H2O2 addition and measured after 24 hrs by MTT assay Neuroprotection against H2O2-induced cell death in human SH-SY5Y cells preincubated for 6 hrs followed by H2O2 addition and measured after 24 hrs by MTT assay	[PMID: 30470490]

In Vitro

Acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. Acetylcysteine also prevents death of PC12 cells and sympathetic neurons^[2].
Acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells^[3].
Acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. Acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. Acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. Acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it is suggested that Acetylcysteine interferes with redox-sensitive steps in the NGF mechanism^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acetylcysteine (150, 300 mg/kg) treatment significantly reduces liver transaminases in all groups of treatment, mostly in group Acetylcysteine 300 mg/kg. Lung glutathione peroxidase is significantly increases in group Acetylcysteine 300 mg/kg(P=0.04), while the other oxidation biomarkers show no significant differences^[6].
Acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 616-91-1
Appearance Solid
Molecular Weight 163.20
Formel C₅H₉NO₃S
Color White to off-white
SMILES

SC[C@@H](C(O)=O)NC(C)=O
Synonyms

N-Acetylcysteine; N-Acetyl-L-cysteine; NAC
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (666)

All Cell Proliferation/Viability AssayWBBio/Physico-chemical Assay

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Journal Impact Factor

Signal Transduct Target Ther

High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming. [Abstract]

2025 Aug 26;10(1):271. PMID: 40854873
Signal Transduct Target Ther

Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS. [Abstract]

2021 May 28;6(1):188. PMID: 34045438
Signal Transduct Target Ther

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis. [Abstract]

2020 May 8;5(1):51. PMID: 32382060
Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell

SLC7A11 is an unconventional H+ transporter in lysosomes. [Abstract]

2025 Jun 26;188(13):3441-3458.e25. PMID: 40280132
Nat Nanotechnol

Ferumoxytol promotes haematopoietic stem cell post-injury regeneration as a reactive oxygen species scavenger. [Abstract]

2025 Apr 23. PMID: 40269251
Mol Cancer

Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway. [Abstract]

2025 Mar 26;24(1):97. PMID: 40140842
Cell Metab

Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis. [Abstract]

2026 Jan 27:S1550-4131(25)00586-8. PMID: 41605214
Cell Metab

Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11. [Abstract]

2024 Aug 9:S1550-4131(24)00285-7. PMID: 39146936
Cell Metab

A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer. [Abstract]

2019 Dec 3;30(6):1107-1119.e8. PMID: 31607564
Nat Genet

Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance. [Abstract]

2023 Dec;55(12):2175-2188. PMID: 37985817
Nat Immunol

Microbiota-shaped neutrophil senescence regulates sexual dimorphism in bladder cancer. [Abstract]

2025 Apr 11. PMID: 40217111
Adv Mater

Acid-Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer. [Abstract]

2023 Mar;35(10):e2209910. PMID: 36576344
Cancer Commun (Lond)

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3-dependent PDGFB signaling. [Abstract]

2025 Nov 10. PMID: 41212905
Sci Bull

Essentiality of SLC7A11-mediated nonessential amino acids in MASLD. [Abstract]

2024 Dec 15;69(23):3700-3716. PMID: 39366830

Acetylcysteine purchased from MedChemExpress. Usage Cited in: Sci Bull. 2024 Dec 15;69(23):3700-3716. [Abstract]

Summary of cell viability measured for MCD-induced wild-type hepatocytes, hepatocytes treated with 2 mmol/L fatty acid (FA) for 24 h with the indicated concentrations of PAG together with 2 mmol/L N-acetylcysteine (NAC) or 5 μmol/L Fer-1.
Cell Stem Cell

Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury. [Abstract]

2024 Aug 21:S1934-5909(24)00285-6. PMID: 39181130
Nat Microbiol

Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages. [Abstract]

2025 Nov;10(11):2949-2965. PMID: 41073667
Nat Microbiol

Oxaloacetate sensing promotes innate immune antiviral defence against influenza virus infection. [Abstract]

2025 Oct;10(10):2521-2536. PMID: 40983701
Adv Funct Mater

2023 May 14.

Acetylcysteine purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2023 May 14.

The viability of MC38 cells treated with PAD@MS for 48 h in the presence or absence of 10 µM Ferr-1 (Ferrostatin-1), 20 µM Nec-1 (Necrostatin-1), 10 µM Z-VAD-FMK, and 1 mM N-Aetyl-L-cysteine (NAC).
Cell Host Microbe

Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival. [Abstract]

2023 Nov 8;31(11):1820-1836.e10. PMID: 37848028
Cancer Res

GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors. [Abstract]

2022 Sep 16;82(18):3223-3235. PMID: 35895805
Sci Immunol

Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation. [Abstract]

2022 Feb 4;7(68):eabk2092. PMID: 35119941
Nat Commun

Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16-CXCR6 signaling for potent antitumor response. [Abstract]

2026 Feb 9;17(1):1441. PMID: 41663428
Nat Commun

Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells. [Abstract]

2025 Dec 17;16(1):11181. PMID: 41407982
Nat Commun

Age mosaic of gut epithelial cells prevents aging. [Abstract]

2025 Jul 22;16(1):6734. PMID: 40695820
Nat Commun

Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma. [Abstract]

2025 Jan 31;16(1):1212. PMID: 39890789
Nat Commun

Methylcobalamin protects against liver failure via engaging gasdermin E. [Abstract]

2025 Jan 31;16(1):1233. PMID: 39890804
Nat Commun

Targeting fatty acid oxidation enhances response to HER2-targeted therapy. [Abstract]

2024 Aug 3;15(1):6587. PMID: 39097623
Nat Commun

Bacteriophage defends murine gut from Escherichia coli invasion via mucosal adherence. [Abstract]

2024 Jun 4;15(1):4764. PMID: 38834561
Nat Commun

Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability. [Abstract]

2024 Mar 16;15(1):2377. PMID: 38493213
Nat Commun

Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo. [Abstract]

2021 Aug 26;12(1):5131. PMID: 34446736
Cell Death Differ

ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance. [Abstract]

2025 Aug 6. PMID: 40770563
Acta Pharm Sin B

Generation and applications of an expandable and mature hiPSC-derived liver organoid. [Abstract]

2025 Dec;15(12):6382-6398. PMID: 41477334
Acta Pharm Sin B

Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis. [Abstract]

2024 Aug;14(8):3493-3512. PMID: 39220878
Acta Pharm Sin B

Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1. [Abstract]

2021 Dec;11(12):4045-4054. PMID: 35024325
Autophagy

Activation of chaperone-mediated autophagy suppresses glioblastoma by promoting wild-type IDH1/isocitrate dehydrogenase 1 degradation. [Abstract]

2025 Nov 30:1-21. PMID: 41231102
Autophagy

METTL3-dependent m6A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation. [Abstract]

2025 Oct;21(10):2168-2191. PMID: 40340690
Autophagy

Inhibition of PINK1 senses ROS signaling to facilitate neuroblastoma cell pyroptosis. [Abstract]

2025 Mar 31. PMID: 40160153
Autophagy

Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis. [Abstract]

2022 May;18(5):971-989. PMID: 34524943
Adv Sci (Weinh)

Cuproptosis and Disulfidptosis Converge to Empower PD-L1 Checkpoint Therapy via Cadict-Induced PD-L1 Translation. [Abstract]

2026 May;13(25):e15367. PMID: 41722054
Adv Sci (Weinh)

Elevated TRIM25 Impairs Poly (ADP-ribose) Metabolism via PARG Degradation and Mediates Compression-Induced Intervertebral Disc Degeneration. [Abstract]

2026 May;13(25):e19248. PMID: 41700742
Adv Sci (Weinh)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism. [Abstract]

2026 Apr;13(19):e16090. PMID: 41618855
Adv Sci (Weinh)

Gallium-Doped MXene Nanozymes Protect Liver Through Multi-Death Pathway Blockade and Hepatocyte Regeneration. [Abstract]

2026 Mar;13(14):e09079. PMID: 41487076
Adv Sci (Weinh)

Biomimetic Nanomedicine for Senescence-Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma. [Abstract]

2025 Dec 23:e17792. PMID: 41432006
Adv Sci (Weinh)

NADH-Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis. [Abstract]

2025 Dec 5:e20444. PMID: 41346305
Adv Sci (Weinh)

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways. [Abstract]

2025 Nov 3:e09151. PMID: 41178446
Adv Sci (Weinh)

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer-Like and Argonaute-Like Proteins. [Abstract]

2025 Sep 8:e06572. PMID: 40919711
Adv Sci (Weinh)

Novel Swelling-Lytic Cell Death Triggered by Cargo-Free Ionizable Lipid Nanoparticles. [Abstract]

2025 Aug 7:e09208. PMID: 40776529

Acetylcysteine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 7:e09208. [Abstract]

Trolox (100 µM), a hydrophilic analogue of VE with potent antioxidant effect, was used as a control of VE. After a short incubation time of 6 h, cathepsin inhibitors (CA‐074, Pep‐A, and E‐64), Ca²⁺ chelator, and cellular ROS scavengers (NAC, VC, and Trolox) displayed a delayed effect of ipLNP cytotoxicity.
Adv Sci (Weinh)

Targeted Dual-Responsive Liposomes Co-Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway. [Abstract]

2025 May 19:e02289. PMID: 40387011
Adv Sci (Weinh)

H. Pylori-Facilitated TERT/Wnt/β-Catenin Triggers Spasmolytic Polypeptide-Expressing Metaplasia and Oxyntic Atrophy. [Abstract]

2024 Nov 25:e2401227. PMID: 39587848
Adv Sci (Weinh)

Mechanical Activation of cPLA2 Impedes Fatty Acid β-Oxidation in Vein Grafts. [Abstract]

2024 Nov 26:e2411559. PMID: 39587975
Adv Sci (Weinh)

Capture of Totipotency in Mouse Embryonic Stem Cells in the Absence of Pdzk1. [Abstract]

2024 Dec 4:e2408852. PMID: 39630006
Adv Sci (Weinh)

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib-Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency. [Abstract]

2024 Dec 16:e2411479. PMID: 39680480
Adv Sci (Weinh)

Targeting Transient Receptor Potential Melastatin-2 (TRPM2) Enhances Therapeutic Efficacy of Third Generation EGFR Inhibitors against EGFR Mutant Lung Cancer. [Abstract]

2024 Jul 23:e2310126. PMID: 39044361
Adv Sci (Weinh)

Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer. [Abstract]

2023 Dec;10(36):e2303484. PMID: 37946697
Adv Sci (Weinh)

Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer. [Abstract]

2023 Sep;10(25):e2301088. PMID: 37428466
Adv Sci (Weinh)

IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death. [Abstract]

2021 Oct;8(19):e2101501. PMID: 34369094
Chem Eng J

2026 Jan 9;529:172705.
Chem Eng J

2024 Nov 28.
J Adv Res

Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD. [Abstract]

2025 Nov 19:S2090-1232(25)00929-4. PMID: 41270956
J Adv Res

Hypericin photoactivation induces triple-negative breast cancer cells pyroptosis by targeting the ROS/CALR/Caspase-3/GSDME pathway. [Abstract]

2025 Jan 25:S2090-1232(25)00059-1. PMID: 39870303
J Adv Res

SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells. [Abstract]

2025 Jan 18:S2090-1232(25)00045-1. PMID: 39832721
Biomaterials

Blue light promotes vitamin C-mediated ferroptosis of melanoma through specifically upregulating transporter SVCT2 and generating Fe2. [Abstract]

2023 Aug:299:122186. PMID: 37276798
Biomaterials

Self-amplified ROS production from fatty acid oxidation enhanced tumor immunotherapy by atorvastatin/PD-L1 siRNA lipopeptide nanoplexes. [Abstract]

2022 Dec:291:121902. PMID: 36371945
Biomaterials

Oxidative stress-driven DR5 upregulation restores TRAIL/Apo2L sensitivity induced by iron oxide nanoparticles in colorectal cancer. [Abstract]

2020 Mar;233:119753. PMID: 31923762
J Exp Clin Cancer Res

Inhibition of RACGAP1 sensitizes triple-negative breast cancer cells to ferroptosis by regulating CPT1A-dependent fatty acid metabolism. [Abstract]

2025 Dec 24;44(1):323. PMID: 41444950
J Exp Clin Cancer Res

Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling. [Abstract]

2025 Aug 27;44(1):255. PMID: 40866941
J Exp Clin Cancer Res

OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway. [Abstract]

2024 Dec 26;43(1):330. PMID: 39721999
J Exp Clin Cancer Res

PPFIA4 promotes castration-resistant prostate cancer by enhancing mitochondrial metabolism through MTHFD2. [Abstract]

2022 Apr 5;41(1):125. PMID: 35382861
J Nanobiotechnology

Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy. [Abstract]

2024 Dec 18;22(1):758. PMID: 39696565
J Nanobiotechnology

Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics. [Abstract]

2021 Apr 20;19(1):112. PMID: 33879173
Sci Adv

Liver regeneration-associated hepatocellular YAP1 activation prevents colorectal cancer liver metastasis through glutamine competition. [Abstract]

2025 Aug 22;11(34):eadw6926. PMID: 40845109
Cell Discov

Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway. [Abstract]

2025 Mar 18;11(1):23. PMID: 40097395
Sci Adv

Self-assembling peptide with dual function of cell penetration and antibacterial as a nano weapon to combat intracellular bacteria. [Abstract]

2025 Feb 7;11(6):eads3844. PMID: 39908383
Carbohydr Polym

Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy. [Abstract]

2025 Mar 1:351:123123. PMID: 39779030
Sci Adv

Chemical conversion of human epidermal stem cells into intestinal goblet cells for modeling mucus-microbe interaction and therapy. [Abstract]

2021 Apr 14;7(16):eabb2213. PMID: 33853767
Mol Ther

RAC1 directly phosphorylates both PKM2 and FBP1 to promote radioresistance in hepatocellular carcinoma. [Abstract]

2025 Nov 7:S1525-0016(25)00870-6. PMID: 41204670
Redox Biol

PP4 modulates macrophage-neutrophil crosstalk to restrict CCL5 -driven NETosis in sepsis. [Abstract]

2026 Apr:91:104093. PMID: 41723906
Redox Biol

Porcine epidemic diarrhea virus promotes viral replication via ROS/HIF-1α-mediated glycolysis. [Abstract]

2026 Jan 5:89:104008. PMID: 41512444
Redox Biol

Neutrophil extracellular traps exacerbate inflammatory arthritis by inhibiting γδ Treg cell differentiation via the AIM2 inflammasome. [Abstract]

2025 Sep 30:87:103881. PMID: 41046783
Redox Biol

Dysregulated lipids homeostasis disrupts CHAC1-mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer. [Abstract]

2025 Jul:84:103693. PMID: 40460553
Redox Biol

LACTB suppresses liver cancer progression through regulation of ferroptosis. [Abstract]

2024 Sep:75:103270. PMID: 39047638
Redox Biol

Tryptanthrin targets GSTP1 to induce senescence and increases the susceptibility to apoptosis by senolytics in liver cancer cells. [Abstract]

2024 Aug 20:76:103323. PMID: 39180983
Redox Biol

SLC7A11 protects luminal A breast cancer cells against ferroptosis induced by CDK4/6 inhibitors. [Abstract]

2024 Aug 10:76:103304. PMID: 39153252
Redox Biol

Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis. [Abstract]

2024 Jun:72:103157. PMID: 38631119
Redox Biol

Breast cancer cells have an increased ferroptosis risk induced by system xc- blockade after deliberately downregulating CYTL1 to mediate malignancy. [Abstract]

2024 Apr:70:103034. PMID: 38211443
Redox Biol

Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation. [Abstract]

2023 Dec:68:102970. PMID: 38035662
Redox Biol

ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis. [Abstract]

2023 Jun:62:102674. PMID: 36989575
Redox Biol

TRIM21 deficiency protects against atrial inflammation and remodeling post myocardial infarction by attenuating oxidative stress. [Abstract]

2023 Jun:62:102679. PMID: 36996623
Redox Biol

RNA binding protein IGF2BP1 meditates oxidative stress-induced granulosa cell dysfunction by regulating MDM2 mRNA stability in an m6A-dependent manner. [Abstract]

2022 Sep 24;57:102492. PMID: 36182806
Redox Biol

Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of β-thalassemia. [Abstract]

2022 Apr:50:102239. PMID: 35092867
Redox Biol

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3. [Abstract]

2019 Jun:24:101215. PMID: 31121492
Engineering

2025 Aug 27.
J Hazard Mater

Silicon carbide nanoparticles induce pulmonary fibrosis by promoting macrophage apoptosis through parkin-mediated mitophagy disruption and the intervention effect of emodin. [Abstract]

2026 Apr 1:507:141765. PMID: 41864028
J Hazard Mater

Acrolein scavengers and detoxification: From high-throughput screening of flavonoids to mechanistic study of epigallocatechin gallate. [Abstract]

2024 Sep 17:480:135873. PMID: 39305594
J Hazard Mater

Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells. [Abstract]

2024 Apr 5:467:133719. PMID: 38335615
J Hazard Mater

Selenomethionine alleviates decabromodiphenyl ether-induced oxidative stress and ferroptosis via the NRF2/GPX4 pathway in the chicken brain. [Abstract]

2024 Mar 5:465:133307. PMID: 38154185
J Hazard Mater

Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells. [Abstract]

2021 Aug 15:416:126158. PMID: 34492938
Gut Microbes

Overconsumption of fructose aggravates acute GVHD by inducing gut dysbiosis and promoting macrophage-mediated inflammatory response. [Abstract]

2026 Dec 31;18(1):2642459. PMID: 41826266
EBioMedicine

SHMT2 regulates CD8+ T cell senescence via the reactive oxygen species axis in HIV-1 infected patients on antiretroviral therapy. [Abstract]

2025 Jan 13:112:105533. PMID: 39808948
EBioMedicine

Neutrophil extracellular traps as a unique target in the treatment of chemotherapy-induced peripheral neuropathy. [Abstract]

2023 Apr:90:104499. PMID: 36870200
MedComm (2020)

Gallium complex K6 inhibits colorectal cancer by increasing ROS levels to induce DNA damage and enhance phosphatase and tensin homolog activity. [Abstract]

2024 Jul 24;5(8):e665. PMID: 39049965
Cell Rep Med

Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis. [Abstract]

2025 Sep 25:102371. PMID: 41005298
Cell Rep Med

Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease. [Abstract]

2023 Mar 21;4(3):100953. PMID: 36809766
Cell Mol Biol Lett

Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer. [Abstract]

2024 Apr 23;29(1):58. PMID: 38649803
Int J Surg

2026 Mar 11.
Mol Biomed

Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice. [Abstract]

2025 Oct 2;6(1):75. PMID: 41037185
Cancer Lett

FABP4-mediated lipid metabolism promotes TNBC progression and breast cancer stem cell activity. [Abstract]

2024 Sep 19:217271. PMID: 39306229
Int J Biol Sci

GSTA1 deficiency drives neuroendocrine differentiation via TNFRSF13B/c-FOS/CHGA axis in prostate cancer. [Abstract]

2026 Jan 14;22(3):1632-1647. PMID: 41608640
Int J Biol Sci

ANXA6 Overexpression Causes Abnormal Decidual Macrophage-Trophoblast Crosstalk in Recurrent Spontaneous Abortion. [Abstract]

2025 Aug 11;21(12):5206-5222. PMID: 40959268
Int J Biol Sci

Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation. [Abstract]

2023 Feb 27;19(5):1471-1489. PMID: 37056925
Int J Biol Sci

4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis. [Abstract]

2022 Oct 24;18(16):6189-6209. PMID: 36439878
Environ Health Perspect

Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and in Vitro Study. [Abstract]

2024 Jun;132(6):67009. PMID: 38896780
Environ Int

Combined effects of ozone and heat on intestinal barrier integrity and epithelial renewal: mediating roles of gut microbiota and tryptophan metabolism. [Abstract]

2026 Feb:208:110128. PMID: 41687337
J Colloid Interface Sci

Engineering a cancer organoid-based platform for the early preclinical evaluation of the antitumor efficacy and safety of hydrophilic 2D metallic MoS2 nanosheets. [Abstract]

2025 Oct 8;703(Pt 2):139206. PMID: 41082801
J Colloid Interface Sci

Redox-engineered gold single-atom nanozymes orchestrate mitochondria-driven PANoptosis for energy-independent cancer catalytic therapy. [Abstract]

2025 Sep 25;703(Pt 1):139108. PMID: 41045899
J Colloid Interface Sci

A "simple" phototheranostic agent for high-performance type I photodynamic and photothermal synergistic cancer therapy. [Abstract]

2025 Sep 25;703(Pt 1):139117. PMID: 41027051
Cell Death Dis

Liver kinase B1 maintains natural killer cell survival by regulating redox homeostasis. [Abstract]

2026 Mar 27;17(1):413. PMID: 41896546
Cell Death Dis

ALDH3A2 negatively orchestrates gastric cancer progression through a synergistic induction of ferroptosis and ferroptosis-driven macrophage reprogramming. [Abstract]

2025 Dec 24. PMID: 41444219
Cell Death Dis

Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD+/Sirt1 pathway in the brain: a possible link between hyperhomocysteinemia and neurodegeneration. [Abstract]

2025 Jul 7;16(1):499. PMID: 40624018
Cell Death Dis

Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis. [Abstract]

2025 Jun 17;16(1):452. PMID: 40523886
Cell Death Dis

Peroxisomal membrane protein PMP70 confers drug resistance in colorectal cancer. [Abstract]

2025 Apr 14;16(1):293. PMID: 40229252
Cell Death Dis

Prostate cancer exploits BRD9-driven metabolic reprogramming to shape the aggressive phenotype. [Abstract]

2025 Apr 22;16(1):326. PMID: 40263302
Cell Death Dis

SNF2L maintains glutathione homeostasis by initiating SLC7A11 transcription through chromatin remodeling. [Abstract]

2024 Nov 12;15(11):820. PMID: 39532848
Cell Death Dis

NIR-715 photodynamic therapy induces immunogenic cancer cell death by enhancing the endoplasmic reticulum stress response. [Abstract]

2024 Dec 18;15(12):890. PMID: 39695072
Cell Death Dis

Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers. [Abstract]

2024 Feb 16;15(2):149. PMID: 38365764
Cell Death Dis

Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth. [Abstract]

2023 Dec 7;14(12):801. PMID: 38062013
Cell Death Dis

Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis. [Abstract]

2023 Apr 6;14(4):246. PMID: 37024456
Cell Death Dis

Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease. [Abstract]

2022 Mar 30;13(3):283. PMID: 35354793
Cell Death Dis

Osteopontin promotes hepatocellular carcinoma progression through inducing JAK2/STAT3/NOX1-mediated ROS production. [Abstract]

2022 Apr 13;13(4):341. PMID: 35418176
Cell Death Dis

High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes. [Abstract]

2021 May 18;12(6):506. PMID: 34006821
Cell Death Dis

SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species. [Abstract]

2021 Jan 12;12(1):77. PMID: 33436551
Cell Death Dis

Autophagy impairment as a key feature for acetaminophen-induced ototoxicity. [Abstract]

2021 Jan 4;12(1):3. PMID: 33414397
Acta Biomater

Delivery of MutT homolog 1 inhibitor by functionalized graphene oxide nanoparticles for enhanced chemo-photodynamic therapy triggers cell death in osteosarcoma. [Abstract]

2020 Jun;109:229-243. PMID: 32294550
Sci China Life Sci

Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis and autophagy via the p53-TFEB/TFE3 axis. [Abstract]

2025 May;68(5):1437-1451. PMID: 40059270
Genes Dis

2025 Sep 23.
Proc Natl Acad Sci U S A

The immunoproteasome regulates ILC2 responses by modulating mitochondrial capacity. [Abstract]

2025 Nov 25;122(47):e2518190122. PMID: 41264257
J Pharm Anal

Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy. [Abstract]

2024 Oct;14(10):101036. PMID: 39850232
Chin Herb Med

Paris saponin VII induces Caspase-3/GSDME-dependent pyroptosis in pancreatic ductal adenocarcinoma cells by activating ROS/Bax signaling. [Abstract]

2024 May 18;17(1):94-107. PMID: 39949804
Cell Commun Signal

Mitochondria-derived methylmalonic acid aggravates ischemia-reperfusion injury by activating reactive oxygen species-dependent ferroptosis. [Abstract]

2024 Jan 18;22(1):53. PMID: 38238728
J Pharm Anal

Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52. [Abstract]

2024 Jan;14(1):86-99. PMID: 38352945
Cell Commun Signal

Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation. [Abstract]

2023 May 25;21(1):123. PMID: 37231437
Cell Commun Signal

The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma. [Abstract]

2020 Oct 28;18(1):174. PMID: 33115468
Cell Commun Signal

TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1. [Abstract]

2019 Nov 19;17(1):149. PMID: 31744518
Dev Cell

Conserved signals control self-organization and symmetry breaking of murine bilayered epithelia during development and regeneration. [Abstract]

2025 Jun 25:S1534-5807(25)00362-4. PMID: 40592344
Int J Biol Macromol

Mechanistic insights into the hepatic metabolism of lentinan: A TLR2-ROS-lysosome axis. [Abstract]

2026 Feb:347:150597. PMID: 41643971
View

2026 Feb 4.
Int J Biol Macromol

CLIC1 regulates cellular oxidative stress and gastric cancer progress by enhancing ACOX1 ubiquitination. [Abstract]

2025 Oct 13;330(Pt 4):148292. PMID: 41093222
Int J Biol Macromol

CircEGLN1 alleviates calcium oxalate-induced renal injury via miR-212-5p/STARD7 axis, offering a potential strategy for kidney stone prevention. [Abstract]

2025 Sep;321(Pt 1):145938. PMID: 40685053
Int J Biol Macromol

Chlorogenic acid mitigates heat stress-induced oxidative damage in bovine mammary epithelial cells by inhibiting NF-κB-mediated NLRP3 inflammasome activation via upregulating the Nrf2 signaling pathway. [Abstract]

2025 Jan 20:140133. PMID: 39842566
Acta Pharmacol Sin

Secoemestrin C exerts rapid and prominent anti-breast cancer effect in triple-negative breast cancer by inducing SLX4 and YAP degradation. [Abstract]

2026 Jan 12. PMID: 41526650
Phytomedicine

Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway. [Abstract]

2026 Jun:155:158126. PMID: 41931998
Phytomedicine

Novel strategies for identification and prevention of idiosyncratic liver injury caused by TCM compatibility: Exemplification by Epimedii Folium and Psoraleae Fructus. [Abstract]

2026 Jan 16:153:157841. PMID: 41655541
Phytomedicine

Therapeutic potential of hydroxytyrosol against bisphenol S-induced toxicity to microglia via targeting cytochrome P450 1A1 (CYP1A1). [Abstract]

2025 Nov 27:150:157629. PMID: 41330185
Phytomedicine

Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via NF-κB pathway inhibition. [Abstract]

2025 Nov 29:150:157633. PMID: 41351983
Phytomedicine

Arnicolide C induces ROS-mediated modulation of PI3K/Akt and MAPK pathways to suppress MYC in hepatocellular carcinoma. [Abstract]

2025 Oct 20:148:157423. PMID: 41138574
Phytomedicine

Specnuezhenide attenuates rheumatoid arthritis bone destruction via dual regulation of osteoclast-osteoblast balance through KEAP1/NRF2 signaling. [Abstract]

2025 Sep 23:148:157293. PMID: 41045622
Phytomedicine

Nrf2-activated mitophagy and ferroptosis suppression synergistically mediate tangeretin's protection against hepatic ischemia-reperfusion injury. [Abstract]

2025 Sep:145:157034. PMID: 40617054
Phytomedicine

Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury. [Abstract]

2025 Jun:141:156672. PMID: 40220406
Phytomedicine

Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence. [Abstract]

2025 Jun:141:156697. PMID: 40215820
Phytomedicine

Melatonin protects RPE cells from necroptosis and NLRP3 activation via promoting SERCA2-related intracellular Ca2+ homeostasis. [Abstract]

2024 Dec:135:156088. PMID: 39341129
Phytomedicine

Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway. [Abstract]

2024 Dec:135:156143. PMID: 39461200
Phytomedicine

Shenqi Pill alleviates acetaminophen-induced liver injury: a comprehensive strategy of network pharmacology and spectrum-effect relationship reveals mechanisms and active components. [Abstract]

2024 Sep 14:135:156050. PMID: 39303509
Phytomedicine

β,β-Dimethylacrylalkannin, a key component of Zicao, induces cell cycle arrest and necrosis in hepatocellular carcinoma cells. [Abstract]

2024 Aug 19:134:155959. PMID: 39178682
Phytomedicine

Trichodelphinine A alleviates pulmonary fibrosis by inhibiting collagen synthesis via NOX4-ARG1/TGF-β signaling pathway. [Abstract]

2024 Sep:132:155755. PMID: 38870750
Phytomedicine

Baicalin and N-acetylcysteine regulate choline metabolism via TFAM to attenuate cadmium-induced liver fibrosis. [Abstract]

2024 Mar:125:155337. PMID: 38241915
Phytomedicine

Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal. [Abstract]

2023 Jul 25:116:154869. PMID: 37196512
BMC Med

NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma. [Abstract]

2022 Oct 19;20(1):365. PMID: 36258210
Phytomedicine

Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1/ROS/mtDNA pathways without increasing bleeding risk. [Abstract]

2022 Sep:104:154271. PMID: 35777120
Free Radic Biol Med

V8, a lysosomotropic wogonin derivative, alleviates hepatic steatosis by modulating GDF15-dependent mitochondrial homeostasis. [Abstract]

2025 Oct 23:S0891-5849(25)01299-7. PMID: 41138960
Free Radic Biol Med

P2Y6 receptor blockade promotes depression-like symptoms through oxidative stress and impaired autophagy. [Abstract]

2025 Oct 17:242:203-219. PMID: 41110517
Free Radic Biol Med

Hyperactivation of the m6A demethylase FTO to down-regulate SLC7A11/xCT-mediated redox homeostasis and epigenetic remodeling in facial infiltrating lipomatosis. [Abstract]

2025 Nov:239:432-448. PMID: 40769313
Free Radic Biol Med

PPARγ mediated lysosomal membrane permeabilization and lipophagy blockage were involved in microplastics and di (2-ethylhexyl) phthalate co-exposure induced immature testis injury. [Abstract]

2025 Sep:237:615-630. PMID: 40532836
Free Radic Biol Med

Fut8 regulated Unc5b hyperfucosylation reduces macrophage emigration and accelerates atherosclerosis development via the ferroptosis pathway. [Abstract]

2025 Apr 20:S0891-5849(25)00235-7. PMID: 40262667
Free Radic Biol Med

MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2. [Abstract]

2025 Apr 30:S0891-5849(25)00272-2. PMID: 40316061
Free Radic Biol Med

Ubiquitination of ALOX15 regulates endoplasmic reticulum stress in Schwann cells and experimental autoimmune neuritis (EAN) models. [Abstract]

2025 Apr 11:S0891-5849(25)00228-X. PMID: 40222426
Free Radic Biol Med

Trimethylamine N-oxide (TMAO) treatment triggers premature ovarian insufficiency (POI) via the activation of mitochondrial pathway apoptosis in granulosa cells. [Abstract]

2025 May:232:214-230. PMID: 40054636
ACS Appl Mater Interfaces

The P2X7-Mediated Mitochondrial ROS as an Emerging Core Target of Tuftsin Nanoparticles in Severe Acute Pancreatitis Therapy via Regulating Mitophagy. [Abstract]

2025 Feb 5;17(5):7521-7538. PMID: 39854589
Free Radic Biol Med

Prohibitin 2 confers NADPH oxidase 1-mediated cytosolic oxidative signaling to promote gastric cancer progression by ERK activation. [Abstract]

2024 Aug 23:S0891-5849(24)00622-1. PMID: 39182738
Free Radic Biol Med

Atorvastatin combined with imipenem alleviates lung injury in sepsis by inhibiting neutrophil extracellular trap formation via the ERK/NOX2 signaling pathway. [Abstract]

2024 Aug 1:220:179-191. PMID: 38704053
Free Radic Biol Med

5-FU promotes HBV replication through oxidative stress-induced autophagy dysfunction. [Abstract]

2024 Mar:213:233-247. PMID: 38215891
Free Radic Biol Med

Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma. [Abstract]

2023 Jul:203:86-101. PMID: 37044150
Free Radic Biol Med

ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance. [Abstract]

2023 Apr:199:126-140. PMID: 36841363
Free Radic Biol Med

ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling. [Abstract]

2023 Feb 1:195:359-370. PMID: 36610560
Free Radic Biol Med

Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP+-induced oxidative stress. [Abstract]

2022 Mar;181:82-97. PMID: 35124181
Free Radic Biol Med

Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS- induced acute lung injury. [Abstract]

2021 Nov 20:176:378-391. PMID: 34644617
Free Radic Biol Med

Lipid overload impairs hepatic VLDL secretion via oxidative stress-mediated PKCδ-HNF4α-MTP pathway in large yellow croaker (Larimichthys crocea). [Abstract]

2021 Aug 20:172:213-225. PMID: 34116177
Free Radic Biol Med

Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress. [Abstract]

2021 Feb 20:164:1-12. PMID: 33388433
Free Radic Biol Med

Polygalacin D suppresses esophageal squamous cell carcinoma growth and metastasis through regulating miR-142-5p/Nrf2 axis. [Abstract]

2021 Feb 20:164:58-75. PMID: 33307164
Free Radic Biol Med

Glsnf1-mediated metabolic rearrangement participates in coping with heat stress and influencing secondary metabolism in Ganoderma lucidum. [Abstract]

2020 Feb 1;147:220-230. PMID: 31883976
Chemosphere

Magnolol ameliorates fumonisin B1-induced oxidative damage and lipid metabolism dysfunction in astrocyte-like C6 cells. [Abstract]

2024 May 8:359:142300. PMID: 38729444
Apoptosis

Loss of AR-regulated AFF3 contributes to prostate cancer progression and reduces ferroptosis sensitivity by downregulating ACSL4 based on single-cell sequencing analysis. [Abstract]

2024 Oct;29(9-10):1679-1695. PMID: 38478171
Sci Total Environ

Ferroptosis participated in inhaled polystyrene nanoplastics-induced liver injury and fibrosis. [Abstract]

2024 Mar 15:916:170342. PMID: 38278228
Sci Total Environ

Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress. [Abstract]

2024 Feb 20:912:169260. PMID: 38086481
Sci Total Environ

Manganese-induced α-synuclein overexpression promotes the accumulation of dysfunctional synaptic vesicles and hippocampal synaptotoxicity by suppressing Rab26-dependent autophagy in presynaptic neurons. [Abstract]

2023 Feb 1;858(Pt 1):159753. PMID: 36341850
J Orthop Translat

SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound. [Abstract]

2025 Apr 25:52:233-248. PMID: 40337549
Br J Pharmacol

Inhibition of GRK2 mitigates cisplatin-induced acute and chronic nephrotoxicity by targeting the NADPH oxidase 4/oxidative stress axis. [Abstract]

2026 Mar 5. PMID: 41782455
Br J Pharmacol

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. [Abstract]

2025 Jul 21. PMID: 40692165
Br J Pharmacol

A mitochondria-targeting and G-quadruplex structure-binding ligand inducing calcium overload and ferroptosis in human cancer cells. [Abstract]

2025 Aug;182(16):3923-3951. PMID: 40344208
Br J Pharmacol

7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death. [Abstract]

2025 May;182(10):2310-2331. PMID: 40038493
Brain Behav Immun

PARP14 inhibits microglial activation via NNT to alleviate depressive-like behaviors in mice. [Abstract]

2025 May:126:235-246. PMID: 39978699
Mucosal Immunol

Deficiency of immunoglobulin IgSF6 enhances antibacterial effects by promoting ER stress and the inflammatory response in intestinal macrophages. [Abstract]

2024 Apr;17(2):288-302. PMID: 38387824
Arch Pharm Res

Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT. [Abstract]

2026 Mar;49(3):357-374. PMID: 41826608
Biomed Pharmacother

Targeting ER stress in adrenocortical carcinoma: Celastrol as a novel therapeutic candidate. [Abstract]

2026 Feb 25:197:119156. PMID: 41747473
JHEP Rep

ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling. [Abstract]

2025 Apr 11;7(8):101423. PMID: 40671832
J Transl Med

TEFM facilitates uterine corpus endometrial carcinoma progression by activating ROS-NFκB pathway. [Abstract]

2024 Dec 27;22(1):1151. PMID: 39731053
Biomed Pharmacother

Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L. [Abstract]

2024 Jul 30:178:117215. PMID: 39084076
Biomed Pharmacother

Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway. [Abstract]

2024 Jun 19:177:117008. PMID: 38901196
J Transl Med

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling. [Abstract]

2024 Jun 10;22(1):555. PMID: 38858642
Biomed Pharmacother

Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes. [Abstract]

2024 May 10:175:116727. PMID: 38733771
Biomed Pharmacother

Pseudolaric acid B suppresses NSCLC progression through the ROS/AMPK/mTOR/autophagy signalling pathway. [Abstract]

2024 Jun:175:116614. PMID: 38670047
J Transl Med

Preclinical evaluation of Mito-LND, a targeting mitochondrial metabolism inhibitor, for glioblastoma treatment. [Abstract]

2023 Aug 7;21(1):532. PMID: 37550679
Biomed Pharmacother

Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation. [Abstract]

2023 Aug:164:114980. PMID: 37301135
Biomed Pharmacother

5-aminolevulinic acid-loaded dissolving microneedle array for photodynamic therapy of rheumatoid arthritis on rats. [Abstract]

2023 Jun:162:114684. PMID: 37058824
JHEP Rep

TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling. [Abstract]

2023 Feb 3;5(5):100695. PMID: 36968217
Biomed Pharmacother

Kaempferol attenuates doxorubicin-induced renal tubular injury by inhibiting ROS/ASK1-mediated activation of the MAPK signaling pathway. [Abstract]

2023 Jan:157:114087. PMID: 36481400
J Transl Med

Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis. [Abstract]

2022 Nov 26;20(1):549. PMID: 36435786
Biomed Pharmacother

Iguratimod ameliorates bleomycin-induced pulmonary fibrosis by inhibiting the EMT process and NLRP3 inflammasome activation. [Abstract]

2022 Sep:153:113460. PMID: 36076570
Biomed Pharmacother

Diterpenoid alkaloids isolated from Delphinium trichophorum alleviate pulmonary fibrosis via the TGF-β/Smad pathway in 3T6 and HFL-1 cells. [Abstract]

2022 May:149:112906. PMID: 36068772
Biomed Pharmacother

Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation. [Abstract]

2021 May:137:111308. PMID: 33556877
Redox Rep

Prophylactic quercetin administration attenuates pulmonary fibrosis via ferroptosis-resistant priming of alveolar epithelial cells. [Abstract]

2026 Dec;31(1):2632434. PMID: 41697789
Arterioscler Thromb Vasc Biol

NAMPT Is A Novel Inhibitor of Vascular Calcification in Chronic Kidney Disease. [Abstract]

2025 Oct;45(10):1872-1892. PMID: 40905115
Redox Rep

ROS-Drp1-mitophagy feedback loop regulates myogenic differentiation via actin cytoskeleton remodeling-mediated MRTF-A/SRF axis. [Abstract]

2025 Dec;30(1):2536400. PMID: 40691128
Redox Rep

CISD2 regulates oxidative stress and mitophagy to maintain the balance of the follicular microenvironment in PCOS. [Abstract]

2024 Dec;29(1):2377870. PMID: 39010730
Cell Mol Gastroenterol Hepatol

Vitamin D receptor activation targets ROS-mediated crosstalk between autophagy and apoptosis in hepatocytes in cholestasis mice. [Abstract]

2023;15(4):887-901. PMID: 36280140
Oncogene

USP10-mediated Ku70/80 stabilization inhibits PANoptosis and promotes chemoresistance in colorectal cancer. [Abstract]

2025 Sep 18. PMID: 40968255
Chin Med J (Engl)

Erianin induces GSDMD-dependent pyroptosis and synergistically enhances doxorubicin efficacy via the PI3K/AKT signaling pathway in diffuse large B-cell lymphoma. [Abstract]

2025 Aug 20. PMID: 40830921
Chin Med J (Engl)

Precision therapy targeting CAMK2 to overcome resistance to EGFR inhibitors in FAT1-mutated oral squamous cell carcinoma. [Abstract]

2024 Sep 3. PMID: 39227322
Environ Pollut

Trace-level Gabapentin can induce cardiovascular developmental toxicity through apoptosis in zebrafish larvae. [Abstract]

2024 Jul 9:124526. PMID: 38992826
Stem Cell Res Ther

LncRNA SNHG1 enhances cartilage regeneration by modulating chondrogenic differentiation and angiogenesis potentials of JBMMSCs via mitochondrial function regulation. [Abstract]

2024 Jun 18;15(1):177. PMID: 38886785
Oncogene

RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-κB activation and ovarian cancer progression. [Abstract]

2024 Feb;43(6):420-433. PMID: 38092960
Environ Pollut

Drp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage. [Abstract]

2021 Mar 1:272:116413. PMID: 33422762
Aging Cell

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence. [Abstract]

2021 Oct;20(10):e13483. PMID: 34587364
Cell Death Discov

ChaC1-based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells. [Abstract]

2025 Nov 17;11(1):532. PMID: 41249117
Cell Death Discov

Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells. [Abstract]

2024 Mar 12;10(1):134. PMID: 38472168
Cell Death Discov

A novel SLC25A1 inhibitor, parthenolide, suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability. [Abstract]

2023 Sep 23;9(1):350. PMID: 37741815
Cell Death Discov

Coal dust nanoparticles induced pulmonary fibrosis by promoting inflammation and epithelial-mesenchymal transition via the NF-κB/NLRP3 pathway driven by IGF1/ROS-mediated AKT/GSK3β signals. [Abstract]

2022 Dec 29;8(1):500. PMID: 36581638
Cell Death Discov

A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis. [Abstract]

2022 May 2;8(1):238. PMID: 35501301
Cell Death Discov

Bak instead of Bax plays a key role in metformin-induced apoptosis s in HCT116 cells. [Abstract]

2021 Nov 22;7(1):363. PMID: 34811352
Cell Death Discov

Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway. [Abstract]

2018 Apr 27:4:47. PMID: 29707240

Acetylcysteine purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2018 Apr 27:4:47. [Abstract]

Wild-type, Prx1^KO, and Prx1^OE cells are each divided into three groups, which are control groups, groups treated with 100 ng/mL LPS, and groups treated with 100 ng/mL LPS and NAC. Western blot analysis is then performed with antibodies against Bax, Bcl-2, Cyto-c, caspase 3, and GAPDH, and band intensity is measured with densitometry.
Microbiol Res

Inhibition of calpain reduces oxidative stress and attenuates pyroptosis and ferroptosis in Clostridium perfringens Beta-1 toxin-induced macrophages. [Abstract]

2024 Dec:289:127916. PMID: 39342748
Cell Rep

PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. [Abstract]

2024 Mar 18;43(3):113930. PMID: 38507412
Cell Rep

Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria. [Abstract]

2023 Sep 26;42(9):113147. PMID: 37756158
Cell Rep

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors. [Abstract]

2019 Jul 9;28(2):512-525.e6. PMID: 31291585
J Med Chem

Phytohormone Strigolactams Overcomes Oxaliplatin Resistance in Colorectal Cancer by Blocking the Late-Stage Autophagy to Tip the Metabolic Balance toward Ferroptosis. [Abstract]

2025 Nov 27;68(22):24546-24559. PMID: 41208142
Clin Transl Med

DDR2-mediated autophagy inhibition contributes to angiotensin II-induced adventitial remodeling. [Abstract]

2025 Jun;15(6):e70361. PMID: 40468620
Clin Transl Med

N-Acetyl-l-cysteine restores reproductive defects caused by Ggt1 deletion in mice. [Abstract]

2021 Aug;11(8):e510. PMID: 34459136
Int Forum Allergy Rhinol

Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1-interleukin 1β (IL-1β) pathway. [Abstract]

2021 Apr;11(4):773-783. PMID: 32779379
Antioxidants (Basel)

Alpha-Lipoic Acid Inhibits IFN-γ-Induced PD-L1 Expression in Prostate Cancer Cells and Enhances T-Cell-Mediated Anti-Tumor Cytotoxicity. [Abstract]

2026 Mar 25;15(4):413. PMID: 42072056
Antioxidants (Basel)

Parthenolide Restores Testosterone Biosynthesis After Nanoplastic Exposure by Blocking ROS-Driven NF-κB Nuclear Translocation. [Abstract]

2025 Oct 31;14(11):1315. PMID: 41300472
Antioxidants (Basel)

Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy. [Abstract]

2024 Nov 24;13(12):1446. PMID: 39765775
Antioxidants (Basel)

Canagliflozin Inhibits Palmitic Acid-Induced Vascular Cell Aging In Vitro through ROS/ERK and Ferroptosis Pathways. [Abstract]

2024 Jul 11;13(7):831. PMID: 39061899
Antioxidants (Basel)

TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo. [Abstract]

2024 Mar 1;13(3):308. PMID: 38539841
Antioxidants (Basel)

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway. [Abstract]

2024 Jan 31;13(2):183. PMID: 38397781
Antioxidants (Basel)

Canagliflozin Delays Aging of HUVECs Induced by Palmitic Acid via the ROS/p38/JNK Pathway. [Abstract]

2023 Mar 30;12(4):838. PMID: 37107212
Antioxidants (Basel)

Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury. [Abstract]

2023 Jan 9;12(1):158. PMID: 36671020
Antioxidants (Basel)

Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia. [Abstract]

2022 Dec 29;12(1):74. PMID: 36670935
Antioxidants (Basel)

Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling. [Abstract]

2022 Sep 18;11(9):1838. PMID: 36139913
J Anim Sci Biotechnol

Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway. [Abstract]

2024 Sep 5;15(1):119. PMID: 39232832
J Cell Biol

Polyploidy reprograms epithelial cells for motility and phagocytosis via stress signaling. [Abstract]

2026 May 4;225(5):e202507096. PMID: 42012408
Elife

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming. [Abstract]

2025 Apr 29:13:RP100406. PMID: 40299922
Phytother Res

Asiatic Acid Alleviates Ulcerative Colitis Through a Gut Microbiota-Driven cAMP/PKA/NF-κB Pathway: γ-Glutamyltyrosine Is a Crucial Player. [Abstract]

2025 Nov 24. PMID: 41277357
Phytother Res

Formosanin C Induces ROS/p38-Mediated Cell Death While Also Promoting Protective Autophagy in Pancreatic Cancer. [Abstract]

2025 Oct 6. PMID: 41054182
Phytother Res

Xanthohumol Regulates Mitophagy in Osteosarcoma Cells via AMPK-ULK1-FUNDC1 Signaling Pathway. [Abstract]

2025 May;39(5):2393-2406. PMID: 40190139
J Pineal Res

Sleep Deprivation Induces Gut Damage via Ferroptosis. [Abstract]

2024 Aug;76(5):e12987. PMID: 38975671
J Agric Food Chem

Mitochondrial Targeting of GSDMD-N and p-MLKL Drives PANoptosis in benzo[ a]pyrene-Induced Hepatotoxicity. [Abstract]

2026 Mar 18;74(10):8758-8770. PMID: 41800912
J Agric Food Chem

Curcumin Alleviates Bisphenol A-Induced Blood-Testis Barrier Disruption in Mice by Targeting Surfactant Protein B (SFTPB) to Suppress Oxidative Stress-Activated NLRP3 Inflammasome. [Abstract]

2025 Nov 19;73(46):29874-29885. PMID: 41212106
Cell Mol Life Sci

Synergetic contributions of Seneca Valley virus 3 C and 3D proteins to induction of ferroptosis for viral replication. [Abstract]

2025 Nov 14;82(1):406. PMID: 41236547
J Agric Food Chem

NEFA Induces Ferroptosis in Transition Dairy Cattle Liver by Increasing Lipid Reactive Oxygen Species and Downregulating SLC7A11. [Abstract]

2025 Jul 30;73(30):18733-18745. PMID: 40684388
J Agric Food Chem

3-MCPD Induces Renal Cell Pyroptosis and Inflammation by Inhibiting ESCRT-III-Mediated Cell Repair and Mitophagy. [Abstract]

2024 Jun 10. PMID: 38857427
J Agric Food Chem

New Insights into Decabromodiphenyl Ether-Induced Splenic Injury in Chickens: Involvement of ROS-Mediated Endoplasmic Reticulum Stress Pathway Triggering Autophagy and Apoptosis. [Abstract]

2024 Feb 21;72(7):3741-3754. PMID: 38340082
J Agric Food Chem

Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice. [Abstract]

2023 Nov 2. PMID: 37917162
J Agric Food Chem

Eugenol Alleviates TGEV-Induced Intestinal Injury via Suppressing ROS/NLRP3/GSDMD-Dependent Pyroptosis. [Abstract]

2023 Jan 25;71(3):1477-1487. PMID: 36642968
J Agric Food Chem

1,3-Dichloro-2-propanol-Induced Renal Tubular Cell Necroptosis through the ROS/RIPK3/MLKL Pathway. [Abstract]

2022 Sep 7;70(35):10847-10857. PMID: 36000575
EMBO Rep

Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction. [Abstract]

2022 Feb 3;23(2):e53499. PMID: 34882936
J Agric Food Chem

Sodium Sulfite-Induced Mast Cell Pyroptosis and Degranulation. [Abstract]

2021 Jul 14;69(27):7755-7764. PMID: 34191510
EMBO Rep

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development. [Abstract]

2021 Jan 7;22(1):e50827. PMID: 33314701
Hepatol Int

Small extracellular vesicles derived from lipotoxic hepatocytes transport FASN to promote hepatic stellate cell activation. [Abstract]

2025 Nov 12. PMID: 41225085
Ecotoxicol Environ Saf

Yttrium nitrate activates the oxidative stress-mediated NF-κB pathway to induce testicular inflammatory response and reduce sperm quality in mice. [Abstract]

2025 Sep 1:302:118720. PMID: 40706520
Ecotoxicol Environ Saf

NQO1 antagonizes PM2.5-induced apoptosis of Sertoli cells by activating the UPRmt pathway. [Abstract]

2025 Sep 1:302:118729. PMID: 40714395
Ecotoxicol Environ Saf

Arsenic exposure provoked prostatic PANoptosis by inducing mitochondrial dysfunction in mice and WPMY-1 cells. [Abstract]

2025 Apr 3:295:118139. PMID: 40185034
Ecotoxicol Environ Saf

Polyhexamethylene guanidine phosphate induces epithelial-to-mesenchymal transition and cancer stem cell-like properties via Wnt/β-catenin signaling in human bronchial epithelial cells. [Abstract]

2025 Mar 1:292:117930. PMID: 39986058
Ecotoxicol Environ Saf

Bisphenol A exposure enhances proliferation and tumorigenesis of papillary thyroid carcinoma through ROS generation and activation of NOX4 signaling pathways. [Abstract]

2025 Mar 1:292:117946. PMID: 40014988
Antioxid Redox Signal

Androgen Receptor Mediates Dopamine Agonist Resistance by Regulating Intracellular Reactive Oxygen Species in Prolactin-Secreting Pituitary Adenoma. [Abstract]

2025 Jun;42(16-18):954-972. PMID: 39360800
Hum Reprod

Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing. [Abstract]

2024 Oct 1;39(10):2189-2209. PMID: 39241251
Ecotoxicol Environ Saf

Polystyrene nanoplastics exposure triggers spermatogenic cell senescence via the Sirt1/ROS axis. [Abstract]

2024 May 18:279:116461. PMID: 38763051
Ecotoxicol Environ Saf

Systolic heart failure induced by butylparaben in zebrafish is caused through oxidative stress and immunosuppression. [Abstract]

2023 Dec:268:115692. PMID: 37981439
Ecotoxicol Environ Saf

Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) indicates mitochondrial dysfunction induces NLRP3 inflammasome and inflammatory cell death in renal tubular epithelial cells. [Abstract]

2022 Aug:241:113790. PMID: 35753275
Ecotoxicol Environ Saf

Potent necrosis effect of methanethiol mediated by METTL7B enzyme bioactivation mechanism in 16HBE cell. [Abstract]

2022 May 1;236:113486. PMID: 35397445
Ecotoxicol Environ Saf

Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-β/Smad signaling pathway in HRMCs. [Abstract]

2021 Nov 30:228:113040. PMID: 34856488
Ecotoxicol Environ Saf

2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) activates Aryl hydrocarbon receptor (AhR) mediated ROS and NLRP3 inflammasome/p38 MAPK pathway inducing necrosis in cochlear hair cells. [Abstract]

2021 Sep 15:221:112423. PMID: 34146985
Ecotoxicol Environ Saf

Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway. [Abstract]

2020 Mar 1;190:110133. PMID: 31896473
Cancer Cell Int

Natural compound triptolide induces caspase-3/GSDME-mediated pyroptosis by promoting ROS accumulation in small cell lung cancer. [Abstract]

2025 Nov 28;25(1):426. PMID: 41316249
Eur J Med Chem

Novel β-carboline derivatives show promise as dual-target inhibitors of DNA and TOP2A for the treatment of triple negative breast cancer. [Abstract]

2025 Nov 15:298:118041. PMID: 40779814
Food Biosci

2025 Mar.
Transl Res

GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis. [Abstract]

2024 May 24:S1931-5244(24)00107-5. PMID: 38797432
Cell Biol Toxicol

LvHemB1, a novel cationic antimicrobial peptide derived from the hemocyanin of Litopenaeus vannamei, induces cancer cell death by targeting mitochondrial voltage-dependent anion channel 1. [Abstract]

2022 Feb;38(1):87-110. PMID: 33630204
Int J Mol Med

Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1. [Abstract]

2023 Nov;52(5):109. PMID: 37800609
J Invest Dermatol

Trehalose Prevents IL-4/IL-13-Induced Skin Barrier Impairment by Suppressing IL-33 Expression and Increasing NRF2 Activation in Human Keratinocytes In Vitro. [Abstract]

2024 Oct 9:S0022-202X(24)02175-4. PMID: 39384017
J Invest Dermatol

TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis. [Abstract]

2024 May 30:S0022-202X(24)00384-1. PMID: 38823435
Atherosclerosis

TIGAR mitigates atherosclerosis by promoting cholesterol efflux from macrophages. [Abstract]

2021 Jun:327:76-86. PMID: 33994201
Biochem Pharmacol

Ellagic acid mediated pyroptosis in hepatocellular carcinoma via the ESR1/G6PD pathway. [Abstract]

2025 Jul 16:241:117178. PMID: 40680865
Biochem Pharmacol

NCOA5 suppresses tumor progression and cisplatin resistance in non-small cell lung cancer by interfering with PRDX6 transcription. [Abstract]

2025 Oct:240:117102. PMID: 40619029
Biochem Pharmacol

Ammonium tetrathiomolybdate attenuates acetaminophen-induced acute liver failure by inhibiting the TRPV4/Calcium/NF-κB signaling pathway. [Abstract]

2025 Apr 10:116917. PMID: 40220797
Biochem Pharmacol

Cotargeting of thioredoxin 1 and glutamate-cysteine ligase in both imatinib-sensitive and imatinib-resistant CML cells. [Abstract]

2025 Jan 18:116763. PMID: 39832669
Biochem Pharmacol

NLRP3 inflammasome activation contributes to the development of the pro-fibrotic phenotype of lung fibroblasts. [Abstract]

2024 Aug 17:116496. PMID: 39159876
Biochem Pharmacol

BACH1 impairs hepatocyte regeneration after hepatectomy with repeated ischemia/reperfusion by reprogramming energy metabolism and exacerbating oxidative stress. [Abstract]

2024 Jun 19:116377. PMID: 38906228
Biochem Pharmacol

Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells. [Abstract]

2024 May:223:116194. PMID: 38583812
Cell Prolif

Intercellular mitochondrial transfer alleviates pyroptosis in dental pulp damage. [Abstract]

2023 Sep;56(9):e13442. PMID: 37086012
Biochem Pharmacol

The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia. [Abstract]

2022 Apr:198:114948. PMID: 35192847
Biochem Pharmacol

Chrysin induces autophagy-dependent ferroptosis to increase chemosensitivity to gemcitabine by targeting CBR1 in pancreatic cancer cells. [Abstract]

2021 Nov:193:114813. PMID: 34673014
Biochem Pharmacol

Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer. [Abstract]

2021 Aug:190:114588. PMID: 33957094
Cell Prolif

Ginsenoside Rb3 provides protective effects against cisplatin-induced nephrotoxicity via regulation of AMPK-/mTOR-mediated autophagy and inhibition of apoptosis in vitro and in vivo. [Abstract]

2019 Jul;52(4):e12627. PMID: 31094028
Inflamm Res

COX5A induces M2 macrophage polarization in chronic rhinosinusitis with nasal polyps through ROS generation. [Abstract]

2026 Mar 17;75(1):64. PMID: 41842984
J Ethnopharmacol

Simo Tang mitigates mitochondria-dependent apoptosis via PI3K/AKT pathway activation in Chronic atrophic gastritis. [Abstract]

2026 May 23:363:121417. PMID: 41765119
J Ethnopharmacol

Osthole promotes skin flap survival by inhibiting ferroptosis and alleviating pyroptosis. [Abstract]

2025 Dec 16:358:121058. PMID: 41406561
Chem Biol Interact

New insights into Lambda-cyhalothrin-induced lipid metabolism disorder in liver: Crosstalk between oxidative stress and PPARα signaling pathway. [Abstract]

2026 Jan 25:424:111872. PMID: 41386472
Chem Biol Interact

Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma. [Abstract]

2025 Jun 18:111614. PMID: 40541645
J Ethnopharmacol

Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy. [Abstract]

2025 May 27:120055. PMID: 40441459
Mar Drugs

Cholestane-3β,5α,6β-triol Induces Multiple Cell Death in A549 Cells via ER Stress and Autophagy Activation. [Abstract]

2024 Apr 13;22(4):174. PMID: 38667791
Geroscience

Di-(2-ethylhexyl) phthalate exposure induces premature testicular senescence by disrupting mitochondrial respiratory chain through STAT5B-mitoSTAT3 in Leydig cell. [Abstract]

2024 Oct;46(5):4373-4396. PMID: 38499958
Chem Biol Interact

Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway. [Abstract]

2023 Sep 1:382:110602. PMID: 37302459
Chem Biol Interact

Hexavalent chromium disrupts the skin barrier by targeting ROS-mediated mitochondrial pathway apoptosis in keratinocytes. [Abstract]

2023 Jul 1:379:110523. PMID: 37146930
J Ethnopharmacol

PI3K/AKT/mTOR, NF-κB and ERS pathway participated in the attenuation of H2O2-induced IPEC-J2 cell injury by koumine. [Abstract]

2023 Mar 25:304:116028. PMID: 36529250
J Ethnopharmacol

Glaucocalyxin A impairs tumor growth via amplification of the ATF4/CHOP/CHAC1 cascade in human oral squamous cell carcinoma. [Abstract]

2022 May 23:290:115100. PMID: 35151835
Mar Drugs

Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells. [Abstract]

2020 Dec 1;18(12):609. PMID: 33271756
Chem Biol Interact

Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells. [Abstract]

2020 Nov 1;331:109279. PMID: 33035517
Mar Drugs

Inspired by Sea Urchins: Warburg Effect Mediated Selectivity of Novel Synthetic Non-Glycoside 1,4-Naphthoquinone-6S-Glucose Conjugates in Prostate Cancer. [Abstract]

2020 May 11;18(5):251. PMID: 32403427
Mar Life Sci Technol

New activities of homoyessotoxin against lung cancer through the regulation of EGFR/PI3K/AKT pathway. [Abstract]

2026 Feb 2;8(1):144-163. PMID: 41783560
Mol Ther Oncolytics

Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis. [Abstract]

2021 Aug 28:23:107-123. PMID: 34703880
J Pathol

Neutrophil extracellular traps aggravate lung injury by inducing pyroptosis of alveolar macrophages. [Abstract]

2026 Jun;269(2):197-209. PMID: 41823322
Cells

The Barrier Disruption and Pyroptosis of Intestinal Epithelial Cells Caused by Perfringolysin O (PFO) from Clostridium perfringens. [Abstract]

2024 Jul 3;13(13):1140. PMID: 38994991
Cells

Hepatic ROS Mediated Macrophage Activation Is Responsible for Irinotecan Induced Liver Injury. [Abstract]

2022 Nov 26;11(23):3791. PMID: 36497051
Microchem J

2026 Feb 9.
Life Sci

Cisplatin transported by COX17 induces cochlear damage by binding Myosin IIA to regulate cell pyroptosis induced by mitochondrial dysfunction. [Abstract]

2025 Nov 1:380:123961. PMID: 40945651
Microchem J

2024 Dec.
Drug Des Devel Ther

ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1. [Abstract]

2024 Aug 29:18:3903-3919. PMID: 39224902
Life Sci

Nicotine induces senescence in spermatogonia stem cells by disrupting homeostasis between circadian oscillation and rhythmic mitochondrial dynamics via the SIRT6/Bmal1 pathway. [Abstract]

2024 Jun 25:122860. PMID: 38936603
Mech Ageing Dev

Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Klotho in coronary atherosclerotic disease. [Abstract]

2023 Apr:211:111789. PMID: 36764463
Drug Des Devel Ther

Andrographolide Inhibits Static Mechanical Pressure-Induced Intervertebral Disc Degeneration via the MAPK/Nrf2/HO-1 Pathway. [Abstract]

2023 Feb 20:17:535-550. PMID: 36845666
Commun Biol

mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling. [Abstract]

2022 Jul 22;5(1):726. PMID: 35869262
Drug Des Devel Ther

Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway. [Abstract]

2020 Nov 13;14:4901-4913. PMID: 33223823
Life Sci

Electroacupuncture ameliorates cardiopulmonary bypass induced apoptosis in lung via ROS/Nrf2/NLRP3 inflammasome pathway. [Abstract]

2019 Dec 1;238:116962. PMID: 31628913
Cancer Gene Ther

b-AP15 enhances TRAIL-induced cell death in HNSCC via the induction of ROS/JNK/DR5 signalling. [Abstract]

2026 May 2. PMID: 42069980
Precis Clin Med

Agrimol B inhibits pancreatic ductal adenocarcinoma by induction of lethal mitophagy through decreasing mitochondrial transcription termination factor 3. [Abstract]

2026 Mar 14;9(2):pbag009. PMID: 41978696
CNS Neurosci Ther

Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway. [Abstract]

2024 Mar;30(3):e14454. PMID: 37697971
Nutrients

Trimethylamine-N-Oxide Promotes Osteoclast Differentiation and Bone Loss via Activating ROS-Dependent NF-κB Signaling Pathway. [Abstract]

2022 Sep 23;14(19):3955. PMID: 36235607
CNS Neurosci Ther

Hypercapnia promotes microglial pyroptosis via inhibiting mitophagy in hypoxemic adult rats. [Abstract]

2020 Nov;26(11):1134-1146. PMID: 32666671
Int J Mol Sci

Baloxavir Acid-Induced Mitochondrial Toxicity and Cell Cycle Arrest Contribute to Its Adverse Effects. [Abstract]

2026 Mar 25;27(7):2967. PMID: 41977157
Biomed Signal Process Control

2026 Feb 26.
J Nutr Biochem

Ketogenic diet modulates AMPK-mTOR pathway in breast cancer. [Abstract]

2026 Jul:153:110312. PMID: 41688032
PLoS Pathog

White spot syndrome virus IE1 protein hijacks the host pentose phosphate pathway to fuel viral replication. [Abstract]

2026 Jan 27;22(1):e1013913. PMID: 41592137
Int J Mol Sci

Xanthohumol Triggers Pyroptotic in Prostate Cancer Cells via the Caspase-3/GSDME Signaling Pathway. [Abstract]

2025 Oct 24;26(21):10347. PMID: 41226386
Biol Direct

Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway. [Abstract]

2025 Aug 22;20(1):94. PMID: 40847353
Int J Mol Sci

Effects of Acrylamide on Mouse Implantation and Decidualization. [Abstract]

2025 Apr 26;26(9):4129. PMID: 40362368
J Nutr Biochem

Genistein upregulates AHR to protect against environmental toxin-induced NASH by inhibiting NLRP3 inflammasome activation and reconstructing antioxidant defense mechanisms. [Abstract]

2023 Nov:121:109436. PMID: 37666477
Int J Mol Sci

Mitochondrial Trafficking of MLKL, Bak/Bax, and Drp1 Is Mediated by RIP1 and ROS which Leads to Decreased Mitochondrial Membrane Integrity during the Hyperglycemic Shift to Necroptosis. [Abstract]

2023 May 11;24(10):8609. PMID: 37239951
Int J Mol Sci

Disulfiram/Cu Kills and Sensitizes BRAF-Mutant Thyroid Cancer Cells to BRAF Kinase Inhibitor by ROS-Dependently Relieving Feedback Activation of MAPK/ERK and PI3K/AKT Pathways. [Abstract]

2023 Feb 8;24(4):3418. PMID: 36834830
Int J Mol Sci

Silica Nanoparticles Promote Apoptosis in Ovarian Granulosa Cells via Autophagy Dysfunction. [Abstract]

2023 Mar 8;24(6):5189. PMID: 36982262
Int J Mol Sci

Diclofenac Sensitizes Signet Ring Cell Gastric Carcinoma Cells to Cisplatin by Activating Autophagy and Inhibition of Survival Signal Pathways. [Abstract]

2022 Oct 11;23(20):12066. PMID: 36292923
Int J Mol Sci

Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. [Abstract]

2022 Apr 26;23(9):4783. PMID: 35563172
Front Cell Infect Microbiol

Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of intracellular iron and reactive oxygen species of macrophages in response to Bacillus Calmette-Guerin infection. [Abstract]

2022 Sep 23:12:1004148. PMID: 36211962
Pharmaceuticals (Basel)

Long-Term Sleep Deprivation-Induced Myocardial Remodeling and Mitochondrial Dysfunction in Mice Were Attenuated by Lipoic Acid and N-Acetylcysteine. [Abstract]

2022 Dec 29;16(1):51. PMID: 36678548
Biomolecules

N-Acetylcysteine, an ROS Inhibitor, Alleviates the Pathophysiology of Hyperthyroidism-Induced Cardiomyopathy via the ROS/Ca2+ Pathway. [Abstract]

2022 Aug 29;12(9):1195. PMID: 36139036
Front Pharmacol

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1. [Abstract]

2022 May 16;13:848957. PMID: 35652039
Front Pharmacol

Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease. [Abstract]

2022 Mar 23:13:809157. PMID: 35401162
Pharmaceuticals (Basel)

Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells. [Abstract]

2021 Sep 22;14(10):949. PMID: 34681173
Front Pharmacol

Effects of Nervilia fordii Extract on Pulmonary Fibrosis Through TGF-β/Smad Signaling Pathway. [Abstract]

2021 Apr 19:12:659627. PMID: 33953686
Cell Oncol (Dordr)

The Xc- inhibitor sulfasalazine improves the anti-cancer effect of pharmacological vitamin C in prostate cancer cells via a glutathione-dependent mechanism. [Abstract]

2020 Feb;43(1):95-106. PMID: 31617161
Bioorg Chem

Lometrexol targets MRPL2 to suppress NSCLC via dual regulation of mitochondrial ribosomal activity and nuclear PDCD11/ Ca2+ signaling. [Abstract]

2026 Mar:170:109509. PMID: 41558196
Eur J Pharmacol

ROS-mediated senescence and autophagy inhibition drive 5-FU/Aumolertinib synergy in colorectal cancer. [Abstract]

2025 Dec 5:1011:178448. PMID: 41352706
Bioorg Chem

Galactomannan tetrasaccharide targets mannose receptor to suppress hepatocellular carcinoma growth through ROS/JNK signaling-induced apoptosis and ROS-mediated autophagy-dependent cell death. [Abstract]

2025 Sep 19:165:109012. PMID: 40992041
Eur J Pharmacol

Alpinetin protects against myocardial ischemia-reperfusion injury by inhibiting ferroptosis and apoptosis via mitochondrial ferritin. [Abstract]

2025 Oct 15:1005:178123. PMID: 40914268
Int Immunopharmacol

Aloperine exerts anti-tumor effect and activates the tumor cell-intrinsic STING pathway in gallbladder cancer. [Abstract]

2025 Sep 23:166:115590. PMID: 40991999
Eur J Pharmacol

OTSSP167 suppresses TNBC brain metastasis via ROS-driven P38/JNK and FAK/ERK pathways. [Abstract]

2025 Oct 5:1004:178017. PMID: 40744390
Int Immunopharmacol

The BPIFA2 - LRP5 axis orchestrates mitochondrial dysfunction to mediate kidney injury in lupus nephritis. [Abstract]

2025 Jun 20:162:115114. PMID: 40543103
Int Immunopharmacol

Elevated transferrin receptor 1 promoting B-cell autoimmunity in systemic lupus erythematosus. [Abstract]

2025 May 14:158:114804. PMID: 40373595
Eur J Pharmacol

Mechanism of berbamine-mediated DNA damage in synovial fibroblasts to alleviate rheumatoid arthritis. [Abstract]

2025 Apr 2:177597. PMID: 40185320
J Mol Struct

2025 Aug 25.
Int Immunopharmacol

Maackiain induces apoptosis and autophagy via ROS-mediated endoplasmic reticulum stress in endometrial cancer. [Abstract]

2025 Jan 4:147:113935. PMID: 39756166
Int Immunopharmacol

Artesunate induces HO-1-mediated cell cycle arrest and senescence to protect against ocular fibrosis. [Abstract]

2024 Aug 15:141:112882. PMID: 39151383
Int Immunopharmacol

Taraxasterol protects against acetaminophen-induced hepatotoxicity by reducing liver inflammatory response and ameliorating oxidative stress in mice. [Abstract]

2024 Jun 28:138:112580. PMID: 38943970
Eur J Pharm Sci

CYP2E1 mediated advanced oxidation protein products exacerbate acetaminophen induced drug-derived liver injury in vitro and in vivo. [Abstract]

2024 Jun 10:106829. PMID: 38866111
Int Immunopharmacol

Oroxylin A suppress LL-37 generated rosacea-like skin inflammation through the modulation of SIRT3-SOD2-NF-κB signaling pathway. [Abstract]

2024 Mar 10:129:111636. PMID: 38364746
Eur J Pharmacol

Xanthohumol attenuates collagen synthesis in scleroderma skin fibroblasts by ROS/Nrf2/TGFβ1/Smad3 pathway. [Abstract]

2024 Jan 15:963:176227. PMID: 38072040
mBio

Respiratory syncytial virus co-opts hypoxia-inducible factor-1α-mediated glycolysis to favor the production of infectious virus. [Abstract]

2023 Oct 31;14(5):e0211023. PMID: 37796013
Int Immunopharmacol

Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling. [Abstract]

2023 Aug 23;124(Pt A):110781. PMID: 37625369
Eur J Pharmacol

Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway. [Abstract]

2023 Oct 15:957:176009. PMID: 37619784
Int Immunopharmacol

Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury. [Abstract]

2021 Mar:92:107352. PMID: 33422760
J Med Virol

Dynamic Interplay Between miR-133a and RBMX During Dengue Virus Infection. [Abstract]

2025 Aug;97(8):e70543. PMID: 40772600
Molecules

Research for a Common Thread: Insights into the Mechanisms of Six Potential Anticancer Agents. [Abstract]

2025 Feb 24;30(5):1031. PMID: 40076255
J Med Virol

Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis. [Abstract]

2024 Oct;96(10):e29945. PMID: 39370874
Molecules

Synergistic Effect of Flavonoids and Metformin on Protection of the Methylglyoxal-Induced Damage in PC-12 Neuroblastoma Cells: Structure-Activity Relationship and Potential Target. [Abstract]

2024 May 14;29(10):2306. PMID: 38792167
Toxicology

Differential susceptibility of BRL cells with/without insulin resistance and the role of endoplasmic reticulum stress signaling pathway in response to acrylamide-exposure toxicity effects in vitro. [Abstract]

2024 May:504:153800. PMID: 38604440
Molecules

Vitexin Regulates Heat Shock Protein Expression by Modulating ROS Levels Thereby Protecting against Heat-Stress-Induced Apoptosis. [Abstract]

2023 Nov 17;28(22):7639. PMID: 38005362
Toxicology

Irisin protects against doxorubicin-induced cardiotoxicity by improving AMPK-Nrf2 dependent mitochondrial fusion and strengthening endogenous anti-oxidant defense mechanisms. [Abstract]

2023 Aug 1:494:153597. PMID: 37499777
Molecules

Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells. [Abstract]

2023 Mar 3;28(5):2358. PMID: 36903603
Toxicology

Maternal exposure to PM2.5 decreases ovarian reserve in neonatal offspring mice through activating PI3K/AKT/FoxO3a pathway and ROS-dependent NF-κB pathway. [Abstract]

2022 Nov:481:153352. PMID: 36243239
Toxicology

AHR/ROS-mediated mitochondria apoptosis contributes to benzo[a]pyrene-induced heart defects and the protective effects of resveratrol. [Abstract]

2021 Oct:462:152965. PMID: 34597721
Mol Oncol

Olaparib synergy screen reveals Exemestane induces replication stress in triple-negative breast cancer. [Abstract]

2025 Jul 13. PMID: 40652528
Cancers (Basel)

Triptolide Triggers Protective Autophagy via ROS Induction in NSCLC: Therapeutic Synergy with Autophagy Inhibition. [Abstract]

2026 Mar 11;18(6):902. PMID: 41899507
Rheumatology (Oxford)

Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence. [Abstract]

2025 Aug 13:keaf437. PMID: 40802538
Cancers (Basel)

Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis. [Abstract]

2022 Dec 15;14(24):6206. PMID: 36551691
Cancers (Basel)

Scabertopin Derived from Elephantopus scaber L. Mediates Necroptosis by Inducing Reactive Oxygen Species Production in Bladder Cancer In Vitro. [Abstract]

2022 Dec 2;14(23):5976. PMID: 36497458
Skelet Muscle

Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin-p53 interaction. [Abstract]

2022 Jul 29;12(1):19. PMID: 35906707
Mol Neurobiol

GPX4 Inhibition Contributes to NLRP3-Mediated Pyroptosis and Cognitive Impairment in Ketamine-Exposed Neonatal Rats. [Abstract]

2025 May 23. PMID: 40404947
Aquat Toxicol

Perfluorooctane sulfonate causes pyroptosis and lipid metabolism disorders through ROS-mediated NLRP3 inflammasome activation in grass carp hepatocyte. [Abstract]

2024 Feb:267:106839. PMID: 38228041
Front Cell Dev Biol

TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells. [Abstract]

2021 Oct 6;9:734818. PMID: 34692691
FASEB J

Penicillide Triggers Immunogenic Pyroptosis in Tumor Cells via Oxidative Stress/NF-κB/GSDMD Signaling Axis. [Abstract]

2026 Mar 31;40(6):e71636. PMID: 41842655
FASEB J

RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux. [Abstract]

2025 Dec 31;39(24):e71369. PMID: 41408993
J Cell Mol Med

Dexamethasone Promotes Autophagy Dependent Ferroptosis of Placental Trophoblast Cells Through GRα. [Abstract]

2025 Jul;29(13):e70613. PMID: 40624893
FASEB J

Artesunate induces ferroptosis in osteosarcoma through NCOA4-mediated ferritinophagy. [Abstract]

2025 Apr 15;39(7):e70488. PMID: 40168090
J Cell Mol Med

NEDD4L affects KLF5 stability through ubiquitination to control ferroptosis and radiotherapy resistance in oesophageal squamous cell carcinoma. [Abstract]

2024 Sep;28(18):e70062. PMID: 39317954
Biochim Biophys Acta Mol Basis Dis

Heme induced progesterone-resistant profiling and promotion of endometriosis in vitro and in vivo. [Abstract]

2023 Oct;1869(7):166761. PMID: 37247698
Drug Dev Res

Shikonin potentiates therapeutic efficacy of oxaliplatin through reactive oxygen species-mediated intrinsic apoptosis and endoplasmic reticulum stress in oxaliplatin-resistant colorectal cancer cells. [Abstract]

2023 May;84(3):542-555. PMID: 36779379
Biochim Biophys Acta Mol Basis Dis

Immune response gene 1 deficiency aggravates high fat diet-induced nonalcoholic fatty liver disease via promotion of redox-sensitive AKT suppression. [Abstract]

2023 Apr;1869(4):166656. PMID: 36706797
J Mol Med (Berl)

Mitochondrial respiration inhibitor enhances the anti-tumor effect of high-dose ascorbic acid in castration-resistant prostate cancer. [Abstract]

2023 Feb;101(1-2):125-138. PMID: 36478125
J Cell Mol Med

MgIG exerts therapeutic effects on crizotinib-induced hepatotoxicity by limiting ROS-mediated autophagy and pyroptosis. [Abstract]

2022 Aug;26(16):4492-4505. PMID: 35855570
FASEB J

LPS stimulation stabilizes HIF-1α by enhancing HIF-1α acetylation via the PARP1-SIRT1 and ACLY-Tip60 pathways in macrophages. [Abstract]

2022 Jul;36(7):e22418. PMID: 35713568
J Food Biochem

Artemisia capillaris Thunb. water extract attenuates adriamycin-induced renal injury by regulating apoptosis through the ROS/MAPK axis. [Abstract]

2022 Feb;46(2):e14065. PMID: 34984698
Bioengineered

Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast. [Abstract]

2021 Dec;12(2):11578-11585. PMID: 34874791
Environ Toxicol Pharmacol

Acute cadmium exposure induces GSDME-mediated pyroptosis in triple-negative breast cancer cells through ROS generation and NLRP3 inflammasome pathway activation. [Abstract]

2021 Oct:87:103686. PMID: 34098069
J Cell Mol Med

Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells. [Abstract]

2021 Apr;25(7):3300-3311. PMID: 33611811
J Cell Mol Med

MD1 deletion exaggerates cardiomyocyte autophagy induced by heart failure with preserved ejection fraction through ROS/MAPK signalling pathway. [Abstract]

2020 Aug;24(16):9300-9312. PMID: 32648659
J Cell Mol Med

FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1. [Abstract]

2022 Jul;26(13):3783-3796. PMID: 35656815
J Cell Mol Med

Tamoxifen inhibits cell proliferation by impaired glucose metabolism in gallbladder cancer. [Abstract]

2020 Jan;24(2):1599-1613. PMID: 31782270
Biogerontology

Antioxidant and anti-aging activities of Salvia miltiorrhiza Bunge callus extracts in H2O2-induced premature senescence and chronological aging models of human dermal fibroblasts. [Abstract]

2026 Feb 7;27(2):54. PMID: 41653369
iScience

Biomimetic hydrogel for the construction of patient-derived bladder cancer organoids with aggressive growth. [Abstract]

2026 Jan 27;29(2):114786. PMID: 41704753
J Inflamm Res

ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway. [Abstract]

2025 Aug 14:18:11095-11108. PMID: 40831518
iScience

Modeling hepatic steatosis with human adult stem cell-derived liver organoids. [Abstract]

2025 Apr 3;28(5):112344. PMID: 40276762
Toxics

Polyethylene Terephthalate Microplastic Exposure Induced Reproductive Toxicity Through Oxidative Stress and p38 Signaling Pathway Activation in Male Mice. [Abstract]

2024 Oct 25;12(11):779. PMID: 39590959
iScience

Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis. [Abstract]

2024 Jul 14;27(8):110496. PMID: 39100694
J Inflamm Res

Exogenous Functional Mitochondria Derived from Bone Mesenchymal Stem Cells That Respond to ROS Can Rescue Neural Cells Following Ischemic Stroke. [Abstract]

2024 May 23:17:3383-3395. PMID: 38803690
iScience

Cinacalcet exhibits rapid bactericidal and efficient anti-biofilm activities against multidrug-resistant Gram-positive pathogens. [Abstract]

2023 Mar 11;26(4):106378. PMID: 37034999
J Inflamm Res

Neutrophil Extracellular Traps Induce Alveolar Macrophage Pyroptosis by Regulating NLRP3 Deubiquitination, Aggravating the Development of Septic Lung Injury. [Abstract]

2023 Feb 27:16:861-877. PMID: 36876152
Biogerontology

SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway. [Abstract]

2023 Oct;24(5):813-827. PMID: 36738354
J Inflamm Res

The β3/5 Integrin-MMP9 Axis Regulates Pulmonary Inflammatory Response and Endothelial Leakage in Acute Lung Injury. [Abstract]

2021 Oct 5;14:5079-5094. PMID: 34675589
Adv Ther

2024 Jul 18.
Adv Ther

2024 April 30.
J Funct Foods

2024 Apr, 115, 106102.
J Funct Foods

2024 Feb, 113, 106040.
Virol Sin

SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria. [Abstract]

2023 Aug;38(4):520-530. PMID: 37156297
J Dermatol Sci

Roflumilast enhances the melanogenesis and attenuates oxidative stress-triggered damage in melanocytes. [Abstract]

2023 May;110(2):44-52. PMID: 37069030
J Funct Foods

2023 Apr.
J Cell Physiol

ETNPPL modulates hyperinsulinemia-induced insulin resistance through the SIK1/ROS-mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes. [Abstract]

2023 May;238(5):1046-1062. PMID: 36924049
Hum Gene Ther

HIV Tat- conjugated Histone H3 peptides induce tumor cell death via cellular stress responses. [Abstract]

2023 Jan;34(1-2):42-55. PMID: 36373826
Sci Rep

Gnetum montanum extract attenuates lipopolysaccharide induced acute lung inflammation through Nrf2 and heme oxygenase 1 mediated redox modulation in macrophages. [Abstract]

2026 Apr 24;16(1):18995. PMID: 42031984
Sci Rep

ROS-NLRP3 participates in the pyroptosis response of excretory-secretory products from protoscoleces of Echinococcus granulosus in hepatocytes. [Abstract]

2026 Mar 20;16(1):14316. PMID: 41862686
Sci Rep

APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer. [Abstract]

2026 Mar 15;16(1):13595. PMID: 41840064
Fish Shellfish Immunol

The AhR/ROS-mediated lipid peroxidation pathway contributes to 6PPDQ-induced intestine-specific injury in zebrafish during embryonic development. [Abstract]

2026 Jun:173:111268. PMID: 41819393
Sci Rep

Oxidative stress imbalance and cellular damage mediated by the ND4 G11778A mutation. [Abstract]

2026 Feb 21;16(1):10122. PMID: 41723241
Sci Rep

New insights into the mechanism of microvascular rarefaction via endothelial-mesenchymal transition in steroid-induced osteonecrosis of femoral head. [Abstract]

2025 Dec 15;16(1):986. PMID: 41398023
Sci Rep

Targeting tumor metabolic flexibility enhances radiotherapeutic efficacy via mitochondrial complex I Inhibition in an intracranial S180 sarcoma mouse model. [Abstract]

2025 Nov 28. PMID: 41310084
Oncol Rep

REV1‑targeting inhibitor JH‑RE‑06 induces ferroptosis via NCOA4‑mediated ferritinophagy in colorectal cancer cells. [Abstract]

2025 Dec;54(6):159. PMID: 40999956
Sci Rep

The synergistic antitumour effect of Carrimycin combined with 5-fluorouracil on colorectal cancer. [Abstract]

2025 Mar 17;15(1):9155. PMID: 40097541
Sci Rep

Triptolide induces apoptosis of glioma cells by inhibiting NF-κB activation during oxidative stress. [Abstract]

2024 Nov 29;14(1):29740. PMID: 39614071
Fish Shellfish Immunol

Grass Carp Reovirus (GCRV) infection activates the PERK-eIF2α pathway to promote the viral replication. [Abstract]

2024 Nov 9:155:110020. PMID: 39528019
Sci Rep

Biocompatible ionized air alleviates rat osteoarthritis by modulating polarization from M1 to M2 macrophages. [Abstract]

2024 Dec 30;14(1):31901. PMID: 39738316
Sci Rep

Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2. [Abstract]

2025 Jan 15;15(1):2028. PMID: 39815001
Oncol Rep

Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration‑resistant prostate cancer cells. [Abstract]

2024 May;51(5):71. PMID: 38577936
J Biol Chem

SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3. [Abstract]

2024 May;300(5):107233. PMID: 38552738
Biomedicines

Long Noncoding RNA AC078850.1 Induces NLRP3 Inflammasome-Mediated Pyroptosis in Atherosclerosis by Upregulating ITGB2 Transcription via Transcription Factor HIF-1α. [Abstract]

2023 Jun 16;11(6):1734. PMID: 37371830
Fish Shellfish Immunol

Nano-selenium protects grass carp hepatocytes against 4-tert-butylphenol-induced mitochondrial apoptosis and necroptosis via suppressing ROS-PARP1 axis. [Abstract]

2023 Apr:135:108682. PMID: 36924910
J Biol Chem

Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity. [Abstract]

2022 Apr;298(4):101753. PMID: 35189139
Aging (Albany NY)

2,5-dimethyl celecoxib induces apoptosis and autophagy via activation of ROS/JNK axis in nasopharyngeal carcinoma cells. [Abstract]

2021 Sep 12;13(17):21483-21496. PMID: 34511433
Aging (Albany NY)

Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS. [Abstract]

2021 Jan 20;13(3):4242-4257. PMID: 33495407
Oncol Rep

DMAPT‑D6 induces death‑receptor‑mediated apoptosis to inhibit glioblastoma cell oncogenesis via induction of DNA damage through accumulation of intracellular ROS. [Abstract]

2021 Mar;45(3):1261-1272. PMID: 33469671
Oncol Rep

Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma. [Abstract]

2020 Oct;44(4):1596-1604. PMID: 32945475
Aging

Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment. [Abstract]

2020 Jun 23;12(13):13437-13462. PMID: 32575075
Sci Rep

Ovariectomy upregulated the expression of Peroxiredoxin 1 &5 in osteoblasts of mice. [Abstract]

2016 Oct 27;6:35995. PMID: 27786251

Acetylcysteine purchased from MedChemExpress. Usage Cited in: Sci Rep. 2016 Oct 27;6:35995. [Abstract]

Pretreatment of NAC, a free radical scavenger, largely decreases the expression of caspase-3 and almost abolishes the H₂O₂ induced upregulation of PRX1. Western blot analysis shows the pretreatment of osteoblast cells with E₂ partially abrogates the increased PRX1 and caspase-3 expressions induced by H₂O₂.
J Virol

Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity. [Abstract]

2026 Feb 17;100(2):e0165625. PMID: 41489372
J Virol

African swine fever virus hijacks host pyrimidine metabolism to promote viral replication. [Abstract]

2025 Nov 25;99(11):e0098525. PMID: 41171159
ACS Infect Dis

The Outer Membrane Protein Tp92 of Treponema pallidum Induces BeWo Cells Apoptosis and Oxidative Stress via the Nrf2/keap1 Pathway. [Abstract]

2025 Aug 19. PMID: 40830074
Cardiovasc Toxicol

Per- and Polyfluoroalkyl Substances (PFAS) Enhance Cholesterol Accumulation and Dysregulate Inflammatory Responses in Macrophages. [Abstract]

2025 Jul 29. PMID: 40728694
Cell Signal

LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux. [Abstract]

2025 Apr 23:132:111834. PMID: 40280227
J Pathol Clin Res

Platinum drugs upregulate CXCR4 and PD-L1 expression via ROS-dependent pathways, with implications for novel combined treatment in gastric cancer. [Abstract]

2025 Jan;11(1):e70015. PMID: 39870588
Cardiovasc Toxicol

Ciprofloxacin Accelerates Angiotensin-II-Induced Vascular Smooth Muscle Cells Senescence Through Modulating AMPK/ROS pathway in Aortic Aneurysm and Dissection. [Abstract]

2024 Sep;24(9):889-903. PMID: 39138741
Cardiovasc Toxicol

N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice. [Abstract]

2024 May;24(5):481-498. PMID: 38647950
Cell Signal

Aldehyde oxidase 1 promotes gallbladder carcinogenesis through ROS-mediated activation of the Wnt/β-catenin pathway. [Abstract]

2024 Apr:116:111042. PMID: 38199597
Biochim Biophys Acta Mol Cell Res

Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells. [Abstract]

2023 Feb;1870(2):119411. PMID: 36521686
Cell Signal

Eldecalcitol induces apoptosis and autophagy in human osteosarcoma MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway. [Abstract]

2021 Feb;78:109841. PMID: 33217539
Heliyon

ARMCX3 regulates ROS signaling, affects neural differentiation and inflammatory microenvironment in dental pulp stem cells. [Abstract]

2024 Aug 28;10(17):e37079. PMID: 39296219
Heliyon

Celastrol induces ferroptosis by suppressing RRM2 in hepatocellular carcinoma. [Abstract]

2024 Jul 2;10(13):e33936. PMID: 39071636
Am J Pathol

Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice. [Abstract]

2024 Feb;194(2):307-320. PMID: 38245252
Bone

Glucocorticoid caused lactic acid accumulation and damage in human chondrocytes via ROS-mediated inhibition of Monocarboxylate Transporter 4. [Abstract]

2022 Feb:155:116299. PMID: 34915176
Microb Pathog

C. albicans airway colonization amplifies inflammation in emphysema through the ROS/NLRP3 pathway of macrophages. [Abstract]

2025 Oct:207:107853. PMID: 40588176
Mol Med Rep

Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis. [Abstract]

2025 Jul;32(1):202. PMID: 40376993
Vet Res

African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation. [Abstract]

2024 Dec 20;55(1):172. PMID: 39707514
Microb Pathog

Degarelix limits the survival of mycobacteria and granuloma formation. [Abstract]

2024 Dec:197:107046. PMID: 39433139

Acetylcysteine purchased from MedChemExpress. Usage Cited in: Microb Pathog. 2024 Dec:197:107046. [Abstract]

BMDMs pretreated with degarelix (1 μM), aminoguanidine hydrochloride (AGHS, 100 μM), BafA1 (100 nM), NAC (5 mM), Z-VAD (20 μM), or 3-MA (5 mM) were infected with H37Rv (MOI = 2). At different time points after infection, bacterial survival was calculated by dividing the CFU at 24 h by the CFU at 3 h.
Vet Res

Regulatory effects of Trichinella spiralis serpin-type serine protease inhibitor on endoplasmic reticulum stress and oxidative stress in host intestinal epithelial cells. [Abstract]

2024 Jun 14;55(1):78. PMID: 38877574
Food Chem Toxicol

Evaluation of cigarette smoke-induced oxidative stress and inflammation in BEAS-2B cells based on a lung microfluidic chip. [Abstract]

2023 Jun:176:113787. PMID: 37062330
Food Chem Toxicol

Hydrogen sulfide protects Sertoli cells against toxicant Acrolein-induced cell injury. [Abstract]

2023 Jun:176:113784. PMID: 37059385
Food Chem Toxicol

Ganoderma lucidum extract-mediated gasdermin E cleavage promotes tumor cell pyroptosis and inhibits metastasis in breast cancer. [Abstract]

2023 Apr:174:113654. PMID: 36758785
Med Oncol

Src inhibitor dasatinib sensitized gastric cancer cells to cisplatin. [Abstract]

2022 Dec 16;40(1):49. PMID: 36525117
Parasit Vectors

A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4-ROS-NLRP3 pathway. [Abstract]

2022 Sep 23;15(1):334. PMID: 36151570
Mol Med Rep

Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway. [Abstract]

2021 Oct;24(4):729. PMID: 34414459
Mol Med Rep

Tannic acid alleviates lipopolysaccharide‑induced H9C2 cell apoptosis by suppressing reactive oxygen species‑mediated endoplasmic reticulum stress. [Abstract]

2021 Jul;24(1):535. PMID: 34080663
Food Chem Toxicol

Lycopene ameliorates chronic stress-induced hippocampal injury and subsequent learning and memory dysfunction through inhibiting ROS/JNK signaling pathway in rats. [Abstract]

2020 Nov;145:111688. PMID: 32810585
BMC Cancer

TRPM2 channels mediate ROS-induced actin remodeling and cell migration of prostate cancer cells. [Abstract]

2025 May 28;25(1):956. PMID: 40437388
Toxicol Appl Pharmacol

H3K9/18 lactylation regulates DNA damage due to nickel exposure in human bronchial epithelial cells. [Abstract]

2025 Apr 16:117347. PMID: 40250488
Cardiovasc Ther

Dehydroevodiamine Alleviates Doxorubicin-Induced Cardiomyocyte Injury by Regulating Neuregulin-1/ErbB Signaling. [Abstract]

2024 Dec 7:2024:5538740. PMID: 39742014
Nat Sci Sleep

TRPC5 Promotes Intermittent Hypoxia-Induced Cardiomyocyte Injury Through Oxidative Stress. [Abstract]

2024 Dec 19:16:2125-2141. PMID: 39720578
J Diabetes Res

Diabetic Cardiomyopathy Uncovered: Transcriptomics, NLRP3, and Carvedilol Mechanisms. [Abstract]

2024 Nov 23:2024:9378405. PMID: 39619569
Eur J Med Res

Exosomal NOX1 promotes tumor-associated macrophage M2 polarization-mediated cancer progression by stimulating ROS production in cervical cancer: a preliminary study. [Abstract]

2023 Sep 7;28(1):323. PMID: 37679792
Toxicol Appl Pharmacol

Bidirectional crosstalk of the cAMP/ROS-dependent signaling pathways in inflammatory macrophage: An activation of formononetin. [Abstract]

2023 Aug 1:472:116571. PMID: 37269934
Acta Biochim Biophys Sin (Shanghai)

Glutamine deprivation induces ferroptosis in pancreatic cancer cells. [Abstract]

2023 Mar 20;55(8):1288-1300. PMID: 36942991
BMC Cancer

Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells. [Abstract]

2022 Jul 2;22(1):724. PMID: 35778693
Toxicol Appl Pharmacol

A novel halogenated adenosine analog 5'-BrDA displays potent toxicity against colon cancer cells in vivo and in vitro. [Abstract]

2022 Feb 1:436:115857. PMID: 34979143
J Immunol

The Microbial Composition of Penaeid Shrimps' Hepatopancreas Is Modulated by Hemocyanin. [Abstract]

2021 Dec 1;207(11):2733-2743. PMID: 34670821
Toxicol Appl Pharmacol

Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways. [Abstract]

2021 May 1:418:115484. PMID: 33716044
J Immunol

Brucella Infection Regulates Thioredoxin-Interacting Protein Expression to Facilitate Intracellular Survival by Reducing the Production of Nitric Oxide and Reactive Oxygen Species. [Abstract]

2020 Feb 1;204(3):632-643. PMID: 31852753
BMC Complement Altern Med

Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway. [Abstract]

2019 Aug 29;19(1):233. PMID: 31464618
Biochim Biophys Acta Mol Cell Biol Lipids

Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels. [Abstract]

2026 Jan;1871(1):159705. PMID: 41213325
Pathogens

N-Acetylcysteine as a Host-Directed Therapy Against Clarithromycin-Resistant Mycobacterium abscessus. [Abstract]

2025 Mar 21;14(4):302. PMID: 40333083
Biochim Biophys Acta Mol Cell Biol Lipids

Peroxisome proliferator-activated receptor gamma is essential for stress adaptation by maintaining lipid homeostasis in female fish. [Abstract]

2022 Jul;1867(7):159162. PMID: 35427795
Front Oncol

The Novel Curcumin Derivative 1g Induces Mitochondrial and ER-Stress-Dependent Apoptosis in Colon Cancer Cells by Induction of ROS Production. [Abstract]

2021 Jun 14;11:644197. PMID: 34195069
Basic Clin Pharmacol Toxicol

Thal protects against paraquat-induced lung injury through a microRNA-141/HDAC6/IκBα-NF-κB axis in rat and cell models. [Abstract]

2021 Feb;128(2):334-347. PMID: 33015978
Int J Med Sci

N-cadherin Alleviates Apoptosis and Senescence of Nucleus Pulposus Cells via Suppressing ROS-dependent ERS in the Hyper-osmolarity Microenvironment. [Abstract]

2024 Jan 1;21(2):341-356. PMID: 38169592
Cell Transplant

Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis. [Abstract]

2023 Jan-Dec:32:9636897231177356. PMID: 37265069
Cell Transplant

Elevated Angiotensin-II Levels Contribute to the Pathogenesis of Open-Angle Glaucoma Via Inducing the Expression of Fibrosis-Related Genes in Trabecular Meshwork Cells Through a ROS/NOX4/SMAD3 Axis. [Abstract]

2023 Jan-Dec:32:9636897231162526. PMID: 36999649
Int J Med Sci

Accumulation of RIPK1 into mitochondria is requisite for oxidative stress-mediated necroptosis and proliferation in Rat Schwann cells. [Abstract]

2022 Oct 31;19(13):1965-1976. PMID: 36438920
Int J Med Sci

N-acetylcysteine Ameliorates Vancomycin-induced Nephrotoxicity by Inhibiting Oxidative Stress and Apoptosis in the in vivo and in vitro Models. [Abstract]

2022 Apr 11;19(4):740-752. PMID: 35582415
Hum Exp Toxicol

EGFR tyrosine kinase inhibitor Almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non-small cell lung cancer cells. [Abstract]

2021 Dec;40(12_suppl):S49-S62. PMID: 34219533
Pharmacology

Tanshinone IIA Ameliorates Inflammation Response in Osteoarthritis via Inhibition of miR-155/FOXO3 Axis. [Abstract]

2021;106(1-2):20-28. PMID: 33395681
Environ Toxicol

Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes. [Abstract]

2021 Apr;36(4):520-529. PMID: 33166055
Environ Toxicol

Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis. [Abstract]

2021 Feb;36(2):257-266. PMID: 32951314
Environ Toxicol

ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling. [Abstract]

2020 Oct;35(10):1100-1113. PMID: 32506763
J Microbiol Biotechnol

Shiga Toxin Induces Apoptosis via ROS-Caspase Activation in Human Cerebral Endothelial Cell Line hCMEC/D3 and Astrocyte Co-Culture. [Abstract]

2026 Jan 8:36:e2512006. PMID: 41508407
Kaohsiung J Med Sci

Kaempferitrin's Dual Assault: Inducing Apoptosis and Ferroptosis in Diffuse Large B-Cell Lymphoma via NF-κB Inactivation. [Abstract]

2025 Oct 1:e70110. PMID: 41031478
Naunyn Schmiedebergs Arch Pharmacol

Kaempferol attenuates cyclosporine-induced renal tubular injury via inhibiting the ROS-ASK1-MAPK pathway. [Abstract]

2025 Mar;398(3):3001-3014. PMID: 39316086
Kaohsiung J Med Sci

Dihydroartemisinin enhances gefitinib cytotoxicity against lung adenocarcinoma cells by inducing ROS-dependent apoptosis and ferroptosis. [Abstract]

2023 Jul;39(7):699-709. PMID: 37057810
Cancer Med

Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation. [Abstract]

2019 May;8(5):2462-2473. PMID: 30972978
BBA Adv

VDAC1 inhibitor DIDS uncouples respiration in isolated tissue mitochondria and induces mitochondrial hyperfusion in mammalian cells. [Abstract]

2025 Oct 8:8:100171. PMID: 41158950
Mol Pharmacol

LZ-106 inhibits anchorage-independent growth of non-small cell lung cancer cells by a positive feedback between reactive oxygen species induction and autophagy flux blockage. [Abstract]

2025 Nov;107(11):100078. PMID: 41110219
Mol Immunol

Psoralidin induces pyroptosis in both tumor cells and macrophages as well as enhances nature killer cell cytotoxicity to suppress hepatocellular carcinoma. [Abstract]

2025 Jun 5:184:22-31. PMID: 40479862
Curr Issues Mol Biol

As2S2 Mediates the ROS/P38 MAPK Signaling Pathway to Induce Apoptosis and S-Phase Arrest in Myelodysplastic Syndrome Cells. [Abstract]

2025 Apr 7;47(4):253. PMID: 40699652
FEBS Lett

Identification of novel anti-leishmanials targeting glutathione synthetase of the parasite: a drug repurposing approach. [Abstract]

2025 Feb;599(3):367-380. PMID: 39266470
Mol Immunol

Activation of TLR4 induces severe acute pancreatitis-associated spleen injury via ROS-disrupted mitophagy pathway. [Abstract]

2022 Feb:142:63-75. PMID: 34965485
Transbound Emerg Dis

Brucella induces heme oxygenase-1 expression to promote its infection. [Abstract]

2022 Sep;69(5):2697-2711. PMID: 34918880
FEBS Lett

AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation. [Abstract]

2021 Oct;595(19):2447-2462. PMID: 34387860
Arch Biochem Biophys

FTY720 induces neutrophil extracellular traps via a NADPH oxidase-independent pathway. [Abstract]

2021 Oct 30:711:109015. PMID: 34437865
Mol Immunol

Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin. [Abstract]

2021 Feb;130:85-95. PMID: 33250268
J Anim Sci

Effects of dietary indole-3-acetate sodium on intestinal morphology, nutrient absorption, and inflammatory responses in weaned piglets. [Abstract]

2026 Jan 8:104:skag048. PMID: 41698006
Mol Brain

Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson's disease. [Abstract]

2025 Apr 4;18(1):29. PMID: 40186271
Free Radic Res

Gold nanoparticles-supported iron oxide particles endows bone scaffolds with anti-tumor function. [Abstract]

2025 Feb 12:1-15. PMID: 39936845
Carcinogenesis

SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma. [Abstract]

2025 Jan 24:bgaf002. PMID: 39851260
Oral Dis

Indoxyl sulfate exacerbates alveolar bone loss in chronic kidney disease through ferroptosis. [Abstract]

2025 Jan;31(1):264-277. PMID: 38934473
Toxicol Lett

Roles of AhR/CYP1s signaling pathway mediated ROS production in uremic cardiomyopathy. [Abstract]

2024 May 15:396:81-93. PMID: 38670245
Am J Cancer Res

LINC02362/hsa-miR-18a-5p/FDX1 axis suppresses proliferation and drives cuproptosis and oxaliplatin sensitivity of hepatocellular carcinoma. [Abstract]

2023 Nov 15;13(11):5590-5609. PMID: 38058825
Int J Biochem Cell Biol

PROTAC-mediated degradation of Class I HDACs by JPS016 alleviates septic cardiomyopathy via mitophagy-driven exopher formation and mitochondrial quality control. [Abstract]

2026 Mar:192:106910. PMID: 41687730
World J Cardiol

Nicotinamide adenine dinucleotide inhibits the production of reactive oxygen species and myocardial cell pyroptosis caused by hypoxia/re-oxygenation injury. [Abstract]

2026 Jan 26;18(1):114108. PMID: 41607618
Mol Biol Rep

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2025 Nov 4;53(1):44. PMID: 41186784
J Biochem Mol Toxicol

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2025 Oct;39(10):e70484. PMID: 40990894
J Appl Toxicol

Exposure to Polyethylene Terephthalate Microplastic Induces Mouse Liver Fibrosis Through Oxidative Stress and p38 MAPK/p65 NF-κB Signaling Pathway. [Abstract]

2025 Sep;45(9):1694-1704. PMID: 40312270
J Appl Toxicol

Synergistic Effect of ROS and p38 MAPK in Apoptosis of TM4 Cells Induced by Titanium Dioxide Nanoparticles. [Abstract]

2025 Apr 14. PMID: 40229128
J Appl Toxicol

Titanium dioxide nanoparticles induce apoptosis through ROS-Ca2+ -p38/AKT/mTOR pathway in TM4 cells. [Abstract]

2024 Jun;44(6):818-832. PMID: 38272789
Mol Biol Rep

Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation. [Abstract]

2024 Jan 6;51(1):86. PMID: 38183539
Mol Biol Rep

Corosolic acid enhances oxidative stress-induced apoptosis and senescence in pancreatic cancer cells by inhibiting the JAK2/STAT3 pathway. [Abstract]

2024 Jan 22;51(1):176. PMID: 38252208
Int J Biochem Cell Biol

Graphene oxide leads to mitochondrial-dependent apoptosis by activating ROS-p53-mPTP pathway in intestinal cells. [Abstract]

2022 May;146:106206. PMID: 35398141
J Appl Toxicol

PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome-mediated hepatocyte pyroptosis. [Abstract]

2022 May;42(5):806-817. PMID: 34687223
Innate Immun

Autophagy plays a protective role during Pseudomonas aeruginosa-induced apoptosis via ROS-MAPK pathway. [Abstract]

2020 Oct;26(7):580-591. PMID: 32878509
Onco Targets Ther

SSPH I, a Novel Anti-Cancer Saponin, Inhibits Autophagy and Induces Apoptosis via ROS Accumulation and ERK1/2 Signaling Pathway in Hepatocellular Carcinoma Cells. [Abstract]

2020 Jun 23;13:5979-5991. PMID: 32606806
Int J Biochem Cell Biol

ROS enhances the cytotoxicity of cisplatin by inducing apoptosis and autophagy in tongue squamous cell carcinoma cells. [Abstract]

2020 May;122:105732. PMID: 32097729
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Radiat Res

Timosaponin AIII Enhances Radiosensitivity in Breast Cancer through Induction of ROS-Mediated DNA Damage and Apoptosis. [Abstract]

2025 Apr 1;203(4):257-270. PMID: 39933562
Animals (Basel)

Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3. [Abstract]

2023 Dec 1;13(23):3723. PMID: 38067074
Vet Microbiol

Porcine circovirus type 2 induces CHOP-ERO1α-ROS-mediated apoptosis in PK-15 cells. [Abstract]

2022 Oct:273:109548. PMID: 36037618
Toxicol In Vitro

Piperlongumine induces apoptosis and G2/M phase arrest in human osteosarcoma cells by regulating ROS/PI3K/Akt pathway. [Abstract]

2020 Jun;65:104775. PMID: 31987842
PLoS One

Silencing NRF2 enhances arsenic trioxide-induced ferroptosis in hepatocellular carcinoma cells. [Abstract]

2025 May 22;20(5):e0322746. PMID: 40402956
Brain Res

Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/autophagy/NLRP3 signal axis in fibrillar Aβ-activated microglia. [Abstract]

2023 Feb 15:1801:148206. PMID: 36539049
Chin J Integr Med

Quercetin Confers Protection against Sepsis-Related Acute Respiratory Distress Syndrome by Suppressing ROS/p38 MAPK Pathway. [Abstract]

2025 Jun 24. PMID: 40553253
Clin Transl Oncol

Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism. [Abstract]

2025 Jun;27(6):2557-2567. PMID: 39612123
Clin Transl Oncol

Effect of doramectin on programmed cell death pathway in glioma cells. [Abstract]

2023 Oct;25(10):2871-2883. PMID: 37084153
Tissue Cell

Raddeanin A induced apoptosis of non-small cell lung cancer cells by promoting ROS-mediated STAT3 inactivation. [Abstract]

2021 Aug:71:101577. PMID: 34146943
Fundam Clin Pharmacol

Advanced oxidation protein products induce apoptosis of human chondrocyte through reactive oxygen species-mediated mitochondrial dysfunction and endoplasmic reticulum stress pathways. [Abstract]

2017 Feb;31(1):64-74. PMID: 27483042

Acetylcysteine purchased from MedChemExpress. Usage Cited in: Fundam Clin Pharmacol. 2017 Feb;31(1):64-74. [Abstract]

Advanced oxidation production product (AOPP)-triggered apoptosis-related signals were triggered by ROS production. Human chondrocytes were pretreated with N-Acetylcysteine (NAC; 5 mM) for 60 min, and then, chondrocyte were co-incubated with AOPP and NAC for 24 h. Pretreatment of ROS scavenger NAC markedly alleviated AOPP-triggered mitochondria-mediated apoptosis proteins.

Acetylcysteine purchased from MedChemExpress. Usage Cited in: Fundam Clin Pharmacol. 2017 Feb;31(1):64-74. [Abstract]

Effect of advanced oxidation production products (AOPPs) on ROS production in human chondrocyte. Human chondrocytes were treated with the indicated concentration of AOPPs (50–400 μg/mL) for 120 min, or 200 μg/mL of AOPPs for the 0–120 min. The intracellular ROS production was determined by measuring the fluorescence of DCFH. Inhibition experiments were carried out by pretreatment for 60 min with N-Acetylcysteine (NAC) (5 mM), and then, chondrocytes were co-incubated with AOPP and NAC for 24 h. Pretreatment of NAC suppressed AOPP-induced ROS production.

Acetylcysteine purchased from MedChemExpress. Usage Cited in: Fundam Clin Pharmacol. 2017 Feb;31(1):64-74. [Abstract]

Advanced oxidation production product (AOPP)-triggered apoptosis-related signals were triggered by ROS production. Human chondrocytes were pretreated with N-Acetylcysteine (NAC; 5 mM) for 60 min, and then, chondrocyte were co-incubated with AOPP and NAC for 24 h. Pretreatment of chondrocyte with NAC abrogated the intracellular Ca²⁺ mobilization.
PeerJ

HMGB1-activatied NLRP3 inflammasome induces thrombocytopenia in heatstroke rat. [Abstract]

2022 Aug 4:10:e13799. PMID: 35945940
J Orthop Res

Dual Regulative Role of Alpha-Kinase 1 on Synovial Angiogenesis and Chondrocyte Ferroptosis in Inflammatory Osteoarthritis. [Abstract]

2026 Jan;44(1):e70116. PMID: 41388916
J Oral Biosci

Antihypertensive agent losartan promotes tongue squamous cell carcinoma cell proliferation via EGFR/ERK1/2/cyclin D1 signaling axis. [Abstract]

2024 Sep 6:S1349-0079(24)00198-1. PMID: 39245205
Immunobiology

The involvement of oxidative stress and the TLR4/NF-κB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia. [Abstract]

2024 May 17;229(3):152809. PMID: 38788361
Exp Ther Med

Cucurbitacin B induces apoptosis in colorectal cells through reactive oxygen species generation and endoplasmic reticulum stress pathways. [Abstract]

2023 Sep 1;26(4):484. PMID: 37753296
Cancer Chemother Pharmacol

Glaucocalyxin A induces apoptosis and autophagy in tongue squamous cell carcinoma cells by regulating ROS. [Abstract]

2021 Aug;88(2):235-246. PMID: 33904969
Biochem Biophys Res Commun

Apelin-13 treats postmenopausal osteoporosis by reducing mitochondrial oxidative phosphorylation and modulating the OPG/RANK/RANKL/IGF-1 pathway. [Abstract]

2025 Sep 29:786:152738. PMID: 41043277
J Mol Histol

Neferine induces cell growth inhibition and apoptosis via ROS-mediated activation of p38 in pancreatic ductal adenocarcinoma cells. [Abstract]

2025 Jul 31;56(4):246. PMID: 40742573
Thromb J

Oroxylin A reverses SHP-2 oxidative inactivation in GPVI signaling to suppress platelet activation and thrombus formation. [Abstract]

2025 Mar 18;23(1):26. PMID: 40102927
Biochem Biophys Res Commun

S-Allyl-L-cysteine (SAC) inhibits copper-induced apoptosis and cuproptosis to alleviate cardiomyocyte injury. [Abstract]

2024 Jul 2:730:150341. PMID: 39018965
Biochem Biophys Res Commun

Piperine induces autophagy of colon cancer cells: Dual modulation of AKT/mTOR signaling pathway and ROS production. [Abstract]

2024 Jul 2:728:150340. PMID: 38968770
Biochem Biophys Res Commun

Mitigation of ROS-triggered endoplasmic reticulum stress by upregulating Nrf2 retards diabetic nephropathy. [Abstract]

2024 Aug 20:721:149972. PMID: 38772213
J Mol Histol

Silibinin ameliorates cisplatin-induced acute kidney injury via activating Nfe2l1-mediated antioxidative response to suppress the ROS/MAPK signaling pathway. [Abstract]

2022 Aug;53(4):729-740. PMID: 35727472
Biochem Biophys Res Commun

Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation. [Abstract]

2022 Jan 8:587:99-106. PMID: 34872005
J Mol Histol

Oxidative stress induced pyroptosis leads to osteogenic dysfunction of MG63 cells. [Abstract]

2020 Jun;51(3):221-232. PMID: 32356234
Biochem Biophys Res Commun

Brucella infection regulates peroxiredoxin-5 protein expression to facilitate intracellular survival by reducing the production of nitric oxide and reactive oxygen species. [Abstract]

2019 Aug 13;516(1):82-88. PMID: 31196623
Biochem Biophys Res Commun

Host defense peptide Hymenochirin-1B induces lung cancer cell apoptosis and cell cycle arrest through the mitochondrial pathway. [Abstract]

2019 Apr 30;512(2):269-275. PMID: 30885438
Connect Tissue Res

Dapagliflozin attenuates lipotoxic tenocyte injury via PPARα activation and irisin-driven antioxidant pathways. [Abstract]

2025 Sep 17:1-13. PMID: 40959984
Anat Rec

Resibufogenin suppresses growth and metastasis through inducing caspase-1-dependent pyroptosis via ROS-mediated NF-κB suppression in non-small cell lung cancer. [Abstract]

2021 Feb;304(2):302-312. PMID: 32396707
Int J Environ Health Res

The ROS/NF-κB/HK2 axis is involved in the arsenic-induced Warburg effect in human L-02 hepatocytes. [Abstract]

2024 Jan;34(1):150-165. PMID: 36264688
Cytotechnology

Acetyl l-carnitine protects adipose-derived stem cells against serum-starvation: regulation on the network composed of reactive oxygen species, autophagy, apoptosis and senescence. [Abstract]

2022 Feb;74(1):105-121. PMID: 35185289
Genes Genomics

Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line. [Abstract]

2021 Oct;43(10):1223-1230. PMID: 34398448
Am J Transl Res

Chlorin A-mediated photodynamic therapy induced apoptosis in human cholangiocarcinoma cells via impaired autophagy flux. [Abstract]

2020 Sep 15;12(9):5080-5094. PMID: 33042407
Curr Med Sci

Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring. [Abstract]

2025 Jun 24. PMID: 40553255
Braz J Med Biol Res

Synergistic effect of venetoclax and ibrutinib on ibrutinib-resistant ABC-type DLBCL cells. [Abstract]

2024 Oct 7:57:e13278. PMID: 39383379
J Int Med Res

Treatment with 7% and 10% CO2 enhanced expression of IL-1β, TNF-α, and IL-6 in hypoxic cultures of human whole blood. [Abstract]

2020 Apr;48(4):300060520912105. PMID: 32264730
Mol Cell Toxicol

2022.
bioRxiv

Gut Microbiota-derived Acetate Safeguards the Colonic Epithelial Acetyl-CoA Reserve to Avert Colonic Senescence. [Abstract]

2026 May 19:2026.05.15.725523. PMID: 42239342
bioRxiv

2026 Mar 31.
Res Sq

2026 Mar 10.
Res Sq

2026 Feb 26.
Res Sq

2026 Feb 5.
Res Sq

2026 Feb 1.
SSRN

2025 Dec 19.
SSRN

2025 Nov 7.
Res Sq

2025 Aug 08.
bioRxiv

2025 Aug 21.
arXiv

2025 Aug 28.
Res Sq

2025 Jul 14.
SSRN

2025 Jun 4.
SSRN

2025 May 7.
Patent

US20250129329A1.
bioRxiv

2025 April 30.
Res Sq

2025 Mar 16.
Res Sq

2024 Sep 08.
Res Sq

2024 Oct 27.
Res Sq

2024 Sep 11.
SSRN

2024 May 22.
bioRxiv

2024 June 21.
SSRN

2024 May 30.
SSRN

2024 Mar 8.
Pharmacological Research-Modern Chinese Medicine

2024 Mar, 10, 100365.
Research Square Preprint

2024 Jan 24.
Research Square Preprint

2023 Oct 13.
SSRN

2023 Sep 13.
Authorea

2023 Aug 7.
Research Square Preprint

2023 May 11.
Research Square Preprint

2023 May 19.
Research Square Print

2023 Feb 20.
J Tradit Chinese Medical Sci

2023 Feb 10.
Environ Sci Pollut Res Int

PbO nanoparticles increase the expression of ICAM-1 and VCAM-1 by increasing reactive oxygen species production in choroid plexus. [Abstract]

2023 Mar;30(14):40162-40173. PMID: 36607576
Research Square Print

December 6th, 2022.
Research Square Print

November 8th, 2022
Research Square Print

October 4th, 2022.
Research Square Print

October 14th, 2022.
Evid Based Complement Alternat Med

Verbena Attenuates Adriamycin-Induced Renal Tubular Injury via Inhibition of ROS-ERK1/2-NLRP3 Signal Pathway. [Abstract]

2022 Sep 28;2022:7760945. PMID: 36212965
Research Square Print

September 1st, 2022.
Oxid Med Cell Longev

PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/ β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib. [Abstract]

2022 Sep 5:2022:9029544. PMID: 36105480
Research Square Print

August 19th, 2022.
Oxid Med Cell Longev

Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE. [Abstract]

2022 Jul 18:2022:5961123. PMID: 35898618
Research Square Preprint

2022 Jun.
Research Square Preprint

2022 May.
Oxid Med Cell Longev

Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy. [Abstract]

2022 Apr 19;2022:4608914. PMID: 35498125
Oxid Med Cell Longev

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2022 Apr 25;2022:3846217. PMID: 35656025
Research Square Print

2022 May.
Oxid Med Cell Longev

Four-Octyl Itaconate Attenuates UVB-Induced Melanocytes and Keratinocytes Apoptosis by Nrf2 Activation-Dependent ROS Inhibition. [Abstract]

2022 Mar 11:2022:9897442. PMID: 35308171
Research Square Preprint

2021 Jul.
Research Square Preprint

2021 Jul.
Oxid Med Cell Longev

Melatonin Ameliorates Corticosterone-Mediated Oxidative Stress-Induced Colitis in Sleep-Deprived Mice Involving Gut Microbiota. [Abstract]

2021 Jun 23:2021:9981480. PMID: 34257825
Oxid Med Cell Longev

The Activation of ROS/NF- κ B/MMP-9 Pathway Promotes Calcium-Induced Kidney Crystal Deposition. [Abstract]

2021 Jun 8:2021:8836355. PMID: 34211634
Research Square Preprint

2021 May.
Oxid Med Cell Longev

Reactive Oxygen Species Mediate Low Back Pain by Upregulating Substance P in Intervertebral Disc Degeneration. [Abstract]

2021 May 14:2021:6681815. PMID: 34093962
Research Square Preprint

2021 Apr.
Research Square Preprint

2021 Mar.
Research Square Preprint

2021 Jan.
Ann Transl Med

Diabetes induces hepatocyte pyroptosis by promoting oxidative stress-mediated NLRP3 inflammasome activation during liver ischaemia and reperfusion injury. [Abstract]

2020 Jun;8(12):739. PMID: 32647664
Research Square Preprint

2020 Jul.
Oxid Med Cell Longev

Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma. [Abstract]

2020 Mar 25;2020:5649174. PMID: 32308804
Biomedical & Life Sciences

2020 Jan, 7: 1-18.
Oxid Med Cell Longev

ROS Reduction Does Not Decrease the Anticancer Efficacy of X-Ray in Two Breast Cancer Cell Lines. [Abstract]

2019 Mar 14:2019:3782074. PMID: 31001373
Journal of China Medical University

2018, 47(8): 692-695, 700.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (612.75 mM; Need ultrasonic)

DMSO : 100 mg/mL (612.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.1275 mL

30.6373 mL

61.2745 mL

5 mM

1.2255 mL

6.1275 mL

12.2549 mL

10 mM

0.6127 mL

3.0637 mL

6.1275 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Konzentration

Volumen

Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (15.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (15.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (15.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 120 mg/mL (735.29 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Protokoll

Cell Assay^[2]

For survival experiments, washed cells are resuspended in RPM1 1640 medium and plated in 0.5 mL at a density of 8-10×10⁵ per well in 24 well plastic culture dishes coated with rat tail collagen. To feed, but to avoid loss of floating cells, fresh medium (0.2 mL) is added to the cultures on days 1, 5, and 10. For experiments involving "primed" PC12 cells, cultures are pretreated for l-2 weeks with NGF in RPM1 1640 medium supplemented with 1% heat-iN-acetylcysteinetivated horse serum. The cells are then washed and passaged into serum-free RPM1 1640 medium.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[6]

Rats: Rats are randomLy allocated into five groups: sham group (n=5), control group with IIR (n=8) and three groups with IIR who are given Acetylcysteine in different dosages: 150 mg/kg intraperitoneally 5 min before ischemia (n=8, group Acetylcysteine 150), 300 mg/kg i.p 5 min before ischemia (n=7, group Acetylcysteine 300), and 150 mg/kg i.p 5 min before ischemia plus 150 mg/kg 5 min before reperfusion (n=7, group Acetylcysteine 150 + 150). After 4 h of reperfusion, the animals are euthanized by exsanguination from the abdominal aorta.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Halasi M, et al. ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors. Biochem J. 2013 Sep 1;454(2):201-8. [Content Brief]

[2]. Ferrari G, et al. N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci. 1995 Apr;15(4):2857-66. [Content Brief]

[3]. Tsai JC, et al. Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem. 1996 Feb 16;271(7):3667-70. [Content Brief]

[4]. Yan CY, et al. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci. 1998 Jun 1;18(11):4042-9. [Content Brief]

[5]. Farr SA, et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem. 2003 Mar;84(5):1173-83. [Content Brief]

[6]. Kalimeris K, et al. N-acetylcysteine ameliorates liver injury in a rat model of intestinal ischemia reperfusion. J Surg Res. 2016 Dec;206(2):263-272. [Content Brief]

[7]. Garigliany MM, et al. N-acetylcysteine lacks universal inhibitory activity against influenza A viruses. J Negat Results Biomed. 2011 May 9;10:5. [Content Brief]

[8]. Gu Q, et al. Disulfidptosis, a novel cell death pathway: molecular landscape and therapeutic implications[J]. Aging Dis, 2024, 10. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	6.1275 mL	30.6373 mL	61.2745 mL	153.1863 mL
	5 mM	1.2255 mL	6.1275 mL	12.2549 mL	30.6373 mL
	10 mM	0.6127 mL	3.0637 mL	6.1275 mL	15.3186 mL
	15 mM	0.4085 mL	2.0425 mL	4.0850 mL	10.2124 mL
	20 mM	0.3064 mL	1.5319 mL	3.0637 mL	7.6593 mL
	25 mM	0.2451 mL	1.2255 mL	2.4510 mL	6.1275 mL
	30 mM	0.2042 mL	1.0212 mL	2.0425 mL	5.1062 mL
	40 mM	0.1532 mL	0.7659 mL	1.5319 mL	3.8297 mL
	50 mM	0.1225 mL	0.6127 mL	1.2255 mL	3.0637 mL
	60 mM	0.1021 mL	0.5106 mL	1.0212 mL	2.5531 mL
	80 mM	0.0766 mL	0.3830 mL	0.7659 mL	1.9148 mL
	100 mM	0.0613 mL	0.3064 mL	0.6127 mL	1.5319 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Acetylcysteine

666 Cited Publications

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Acetylcysteine

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Acetylcysteine Related Classifications

Art. -Nr.: HY-B0215