CT-133
CT-133 is a selective and potent CRTH2 Receptor antagonist, with a Ki value of 2.2 nM. The Ki value for the DP1 receptor is greater than 3800 nM. CT-133 inhibits neutrophil migration induced by PGD2 (HY-101988). CT-133 significantly alleviates lung inflammation and improves lung function impairment in a mouse model of acute lung injury (ALI) induced by cigarette smoke. CT-133 effectively inhibits the excessive expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokines (KC), and reverses the inhibition of the anti-inflammatory factor IL-10. CT-133 can be used for the study of ALI.
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- CAS. Nr.: 2417155-47-4
- Formel: C20H19FN3NaO4S
- Molecular Weight:439.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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IL-6 |
IL-1β |
IL-10 |
Chemical Information
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CAS. Nr. 2417155-47-4
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Molecular Weight 439.44
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Formel C20H19FN3NaO4S
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SMILES
O=C(O[Na])CC1=C2N(C[C@@H](CC2)N(C)S(=O)(C3=CC=C(C=C3)F)=O)C4=NC=CC=C41
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CT-133 Related Classifications
HY-160844 Related Classifications
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