Friedelin
Based on 2 publication(s) in Google Scholar
Friedelin is derived from the leaves of Maytenus ilicifolia (Mart). Friedelin is an orally active non-competitive inhibitor of CYP3A4, with IC50 and Ki values of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1, with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively. Friedelin can be used in research related to inflammation, neurological diseases, and metabolic disorders.
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- Reinheit: 99.0%
- CAS. Nr.: 559-74-0
- Formel: C30H50O
- Molecular Weight:426.72
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Speicherung:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Friedelin
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Biologische Aktivität
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CYP2 |
CYP3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
11.1 μM
Compound: 4
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Growth inhibition of human A549 cells by MTT assay
Growth inhibition of human A549 cells by MTT assay
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[PMID: 20153184] |
| BV-2 | IC50 |
>50 μM
Compound: 10
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Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells
Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells
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[PMID: 18926710] |
| CHO | EC50 |
>10 μM
Compound: Friedeline
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Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
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[PMID: 19911773] |
| COS-1 | EC50 |
0 μM
Compound: Friedeline
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Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay
Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay
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[PMID: 19911773] |
| HepG2 2.2.15 | CC50 |
1787.4 μM
Compound: C1; F
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Cytotoxicity against human HepG2.215 cells assessed as reduction in cell viability after 3 days by MTT assay
Cytotoxicity against human HepG2.215 cells assessed as reduction in cell viability after 3 days by MTT assay
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[PMID: 29627260] |
| HL-60 | GI50 |
12.2 μM
Compound: 4
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Growth inhibition of human HL60 cells by MTT assay
Growth inhibition of human HL60 cells by MTT assay
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[PMID: 20153184] |
| HT-29 | GI50 |
13.5 μM
Compound: 4
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Growth inhibition of human HT-29 cells by MTT assay
Growth inhibition of human HT-29 cells by MTT assay
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[PMID: 20153184] |
| MCF7 | GI50 |
>100 μM
Compound: 1
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Cytotoxicity against human MCF7 cells by SRB assay
Cytotoxicity against human MCF7 cells by SRB assay
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[PMID: 11678649] |
| NCI-H460 | GI50 |
>100 μM
Compound: 1
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Cytotoxicity against human NCI-H460 cells by SRB assay
Cytotoxicity against human NCI-H460 cells by SRB assay
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[PMID: 11678649] |
| SF-268 | GI50 |
>100 μM
Compound: 1
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Cytotoxicity against human SF268 cells by SRB assay
Cytotoxicity against human SF268 cells by SRB assay
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[PMID: 11678649] |
| SK-OV-3 | GI50 |
12.7 μM
Compound: 4
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Growth inhibition of human SKOV3 cells by MTT assay
Growth inhibition of human SKOV3 cells by MTT assay
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[PMID: 20153184] |
| TK-10 | GI50 |
>100 μM
Compound: 1
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Cytotoxicity against human TK10 cells by SRB assay
Cytotoxicity against human TK10 cells by SRB assay
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[PMID: 11678649] |
| UACC-62 | GI50 |
>100 μM
Compound: 1
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Cytotoxicity against human UACC62 cells by SRB assay
Cytotoxicity against human UACC62 cells by SRB assay
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[PMID: 11678649] |
Friedelin (40 μM, 24 hours) significantly inhibits NF-κB pathway activation and reduced inflammatory responses in tenocytes[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Tenocytes (Tendinopathy)
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Concentration:40 μM
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Incubation Time:24 hours
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Result:Significantly inhibited NF-κB pathway activation, reduced expression of inflammatory factors IL-1β, IL-6, and TNF-α.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Scopolamine (HY-N0296)-induced neurodegeneration mice model[3]
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Dosage:30 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily, for 14 days
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Result:Improved scopolamine-induced oxidative stress, neurodegeneration, and memory impairment.
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Animal Model:Carrageenan (HY-125474)-induced acute inflammation Wistar rats model[2]
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Dosage:40 mg/kg
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Administration:Oral gavage (p.o.), single dose
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Result:Maximally inhibited acute inflammatory response, significantly reduced paw edema thickness.
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Animal Model:Collagenase Type I (HY-E70005A)-induced tendinopathy C57BL/6 mice model[4]
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Dosage:40 μM
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Administration:Local injection near the right Achilles tendon, once weekly, for 4 weeks
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Result:Significantly improved tendon mechanical strength, reduced inflammatory cell infiltration, restored ordered collagen fiber arrangement.
Chemical Information
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CAS. Nr. 559-74-0
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Appearance Solid
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Molecular Weight 426.72
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Formel C30H50O
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Color White to off-white
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SMILES
C[C@@]12[C@]([C@@]3([H])[C@](C)(CCC(C)(C)C3)CC1)(CC[C@]4(C)[C@]2([H])CC[C@@]([C@H]5C)(C)[C@@]4([H])CCC5=O)C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Friedelin suppresses osteoclastogenesis via sequential dual-targeting of p105 processing and STAT3-mediated metabolic reprogramming. [Abstract]2026 Jun:155:158197. PMID: 42001836 -
Nutrients
Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65. [Abstract]2022 Apr 18;14(8):1673. PMID: 35458235
Lösungsmittel & Löslichkeit
THF : 8.33 mg/mL (19.52 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Wei J, et al. In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes. Pharm Biol. 2018 Dec;56(1):363-367. [Content Brief]
[2]. Antonisamy P, et al. Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models. J Pharm Pharmacol. 2011 Aug;63(8):1070-7. [Content Brief]
[3]. Sandhu M, et al. Friedelin Attenuates Neuronal Dysfunction and Memory Impairment by Inhibition of the Activated JNK/NF-κB Signalling Pathway in Scopolamine-Induced Mice Model of Neurodegeneration. Molecules. 2022 Jul 14;27(14):4513. [Content Brief]
[4]. Jiang H, et al. Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65. Nutrients. 2022 Apr 18;14(8):1673. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| THF | 1 mM | 2.3435 mL | 11.7173 mL | 23.4346 mL | 58.5864 mL |
| 5 mM | 0.4687 mL | 2.3435 mL | 4.6869 mL | 11.7173 mL | |
| 10 mM | 0.2343 mL | 1.1717 mL | 2.3435 mL | 5.8586 mL | |
| 15 mM | 0.1562 mL | 0.7812 mL | 1.5623 mL | 3.9058 mL |
Friedelin Related Classifications
HY-N4110 Related Classifications
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