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Art. -Nr.: HY-163430

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HDAC-IN-71

HDAC-IN-71 (Compound 17q) is a potent HDAC inhibitor with IC₅₀ values of 12.6, 14.1, 20, 3, and 72 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC10, respectively. HDAC-IN-71 induces apoptosis and can be used in cancer research.

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CAS. Nr.: 2995354-52-2
Formel: C₁₉H₂₄N₂O₅
Molecular Weight:360.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

HDAC-IN-71 Chemical Structure

CAS. Nr.: 2995354-52-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

HDAC1

12.6 nM (IC₅₀)

HDAC2

14.1 nM (IC₅₀)

HDAC3

20 nM (IC₅₀)

HDAC6

3 nM (IC₅₀)

HDAC10

72 nM (IC₅₀)

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.39 μM Compound: 17q	Antiproliferative activity against human A549 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
DU-145	IC₅₀	0.16 μM Compound: 17q	Antiproliferative activity against human DU-145 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human DU-145 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
HCT-116	IC₅₀	0.47 μM Compound: 17q	Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
HT-29	IC₅₀	1.05 μM Compound: 17q	Antiproliferative activity against human HT-29 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human HT-29 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
LNCaP	IC₅₀	0.63 μM Compound: 17q	Antiproliferative activity against human LNCaP cells incubated for 96 hrs by MTT assay Antiproliferative activity against human LNCaP cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
MCF7	IC₅₀	0.35 μM Compound: 17q	Antiproliferative activity against human MCF7 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
MDA-MB-231	IC₅₀	0.31 μM Compound: 17q	Antiproliferative activity against human MDA-MB-231 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
NCI-H1650	IC₅₀	3.56 μM Compound: 17q	Antiproliferative activity against human NCI-H1650 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human NCI-H1650 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
NCI-H446	IC₅₀	0.65 μM Compound: 17q	Antiproliferative activity against human NCI-H446 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human NCI-H446 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
PC-3	IC₅₀	0.72 μM Compound: 17q	Antiproliferative activity against human PC-3 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human PC-3 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]

In Vitro

HDAC-IN-71 (0-1.6 μM; 24 h) inhibits colony formation in a dose-dependent manner and completely inhibits colony formation of DU145 cells at a concentration of 3.2 μM^[1].
HDAC-IN-71 (0-1.6 μM; 72 h) arrests cells in G2/M phase and induces apoptosis in DU145 cell line in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

DU145 cells
Concentration:

0, 0.2, 0.4, 0.8, 1.6 μM
Incubation Time:

12 h
Result:

Inhibited cancer cell migration.

Cell Cycle Analysis^[1]

Cell Line:

DU145 cells
Concentration:

0, 0.2, 0.4, 0.8, 1.6 μM
Incubation Time:

72 h
Result:

Arrested cells in G2/M phase in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

DU145 cells
Concentration:

0.8, 1.6, 3.2 μM
Incubation Time:

24 h
Result:

Induced histone acetylation and inhibited HDAC6 expression.

In Vivo

HDAC-IN-71 (100, 200 mg/kg; p.o.; daily; 40 days) inhibits tumor growth at concentrations of 100 mg/kg and 200 mg/kg, with TGI values of 50.92% and 68.00% respectively^[1].
Pharmacokinetic analysis^[1]

Parameters	I.V. (2 mg/kg)	P.O. (10 mg/kg)
AUC_0-∞ (h ng/mL)	1633.35	3799.46
T_1/2 (h)	3.12	2.87
CL (L/h/kg)	1.57
V (L/kg)	4.63
C_max(ng/mL)	851.5	774.0
F		46.52%

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c nude mice^[1]
Dosage:

100, 200 mg/kg
Administration:

Oral administration; daily; 40 days
Result:

Significantly inhibited prostate cancer (PCa) tumor growth.

Chemical Information

CAS. Nr. 2995354-52-2
Molecular Weight 360.40
Formel C₁₉H₂₄N₂O₅
SMILES

COC1=C(C=CC=C1)/C=C2CC(N(C\2=O)CCCCCCC(NO)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jiang Q, et al. Discovery of novel itaconimide-based derivatives as potent HDAC inhibitors for the efficient treatment of prostate cancer. Eur J Med Chem. 2024 Apr 5;269:116315. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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