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Art. -Nr.: HY-187813

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HDAC2-IN-4

HDAC2-IN-4 is a HDAC2 inhibitor with an IC₅₀ of 4.2 nM against human HDAC2. HDAC2-IN-4 binds to the active site of HDAC2 via hydrogen bonding and hydrophobic interactions, forming a thermodynamically stable and kinetically compatible protein-ligand complex to inhibit enzymatic activity. HDAC2-IN-4 inhibits cancer cell proliferation and exhibits low toxicity to normal cells. HDAC2-IN-4 can be used in studies related to human endocervical adenocarcinoma and Burkitt lymphoma.

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Formel: C₁₉H₂₈N₂O₅
Molecular Weight:364.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC2-IN-4 Chemical Structure

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Preis

Verfügbarkeit

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

hHDAC2

4.2 nM (IC₅₀)

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC50	5.07 μM	Antiproliferative activity against human endocervical adenocarcinoma HeLa cells assessed by resazurin assay after 72 h incubation with the compound followed by 3 h resazurin incubation. Antiproliferative activity against human endocervical adenocarcinoma HeLa cells assessed by resazurin assay after 72 h incubation with the compound followed by 3 h resazurin incubation.	42520173
Raji	IC50	1.87 μM	Antiproliferative activity against human Burkitt's lymphoma Raji cells assessed by resazurin assay after 72 h incubation with the compound followed by 3 h resazurin incubation. Antiproliferative activity against human Burkitt's lymphoma Raji cells assessed by resazurin assay after 72 h incubation with the compound followed by 3 h resazurin incubation.	42520173

In Vitro

HDAC2-IN-4 (23e) (0.1-100 μM; 1 h) potently inhibits purified human HDAC2 protein, with an IC₅₀ of 4.2 nM^[1].
HDAC2-IN-4 (500 ns) forms a thermodynamically stable and kinetically compatible complex with human HDAC2 protein^[1].
HDAC2-IN-4 (0.1-250 μM; 72 h) potently inhibits the proliferation of HeLa and Raji cancer cells, with IC₅₀ values of 5.07 μM and 1.87 μM, respectively, while exhibiting low toxicity toward non-cancerous Hek293T and DF cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

human endocervical adenocarcinoma (HeLa) cells, human Burkitt's lymphoma (Raji) cells, human embryonic kidney (Hek293T) non-cancer cells, primary human dermal fibroblasts (DF) non-cancer cells
Concentration:

0.1, 1, 10, 50 and 250 μM
Incubation Time:

72 h
Result:

Exhibited pronounced antiproliferative activity against HeLa cells with an IC₅₀ of 5.07 μM.
Exhibited pronounced antiproliferative activity against Raji cells with an IC₅₀ of 1.87 μM.
Showed low toxicity against non-cancer Hek293T and DF cells, demonstrating selective cytotoxicity toward malignant cells.

Chemical Information

Molecular Weight 364.44
Formel C₁₉H₂₈N₂O₅
SMILES

O=C(OCCCC)C1=CC=C(NC(CCCCCCC(NO)=O)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lisouskaya M, et al. Design, Synthesis, In Vitro Evaluation, and Molecular Docking of 4-Substituted Anilides as Histone Deacetylase Inhibitors and Potential Anticancer Agents. Chemistry & biodiversity. 2026 Jul;23(7):e71516.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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HDAC2-IN-4

Alle HDAC Isoform-spezifische Produkte anzeigen