Ochratoxin A-D4
Ochratoxin A-D4 (Phe-OTA-D4) is the deuterium labeled Ochratoxin A. Ochratoxin A is an orally active food-borne mycotoxin that can cross the blood-brain barrier. Ochratoxin A is a secondary metabolite of fungi belonging to the genera Aspergillus and Penicillium, and is classified as a Group 2B carcinogen. Ochratoxin A exerts its effects through multiple pathways, including inducing oxidative stress, inhibiting mitochondrial respiration, causing oxidative DNA damage, disrupting the PPAR-γ-CD36 axis, inducing immunosuppression, generating ROS, mediating mitochondria-dependent apoptosis, inhibiting glutamate uptake, triggering demyelination and neuroinflammation, inducing DNA hypomethylation, and inhibiting cell proliferation. Ochratoxin A can induce nephrotoxicity, hepatotoxicity, immunotoxicity, and neurotoxicity, and also exhibits mutagenicity, teratogenicity, and carcinogenicity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1448049-50-0
- Formel: C20H14D4ClNO6
- Molecular Weight:407.84
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
MoreAlle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
0.08 μM
Compound: 2
|
Induction of apoptosis in human HepG2 cells assessed as caspase 3 activation after 24 hrs by fluorescence assay
Induction of apoptosis in human HepG2 cells assessed as caspase 3 activation after 24 hrs by fluorescence assay
|
[PMID: 19919898] |
| HepG2 | IC50 |
0.4 μM
Compound: 2
|
Cytotoxicity against human HepG2 cells after 48 hrs by WST8 assay
Cytotoxicity against human HepG2 cells after 48 hrs by WST8 assay
|
[PMID: 19919898] |
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS. Nr. 1448049-50-0
-
Molecular Weight 407.84
-
Formel C20H14D4ClNO6
-
SMILES
O=C(O)[C@H](CC1=CC=CC=C1)NC(C2=CC(Cl)=C(C3=C2O)C[C@](C([2H])([2H])[2H])([2H])OC3=O)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9. [Content Brief]
[2]. Bouisseau A, et al. First synthesis of a stable isotope of Ochratoxin A metabolite for a reliable detoxification monitoring. Org Lett. 2013 Aug 2;15(15):3888-90. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Ochratoxin A-D4 Related Classifications
HY-108385 Related Classifications
Powered by Bioz