Sanazole
Sanazole (AK-2123) is a hypoxic cell radiosensitizer. Sanazole enhances radiation-induced DNA strand breaks. In mouse fibroblast tumors, Sanazole increases nuclear condensation and fragmentation, as well as elevates caspase-3 activity, thereby enhancing radiation-induced apoptosis.
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- CAS. Nr.: 104958-90-9
- Formel: C7H11N5O4
- Molecular Weight:229.19
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Chemical Information
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CAS. Nr. 104958-90-9
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Molecular Weight 229.19
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Formel C7H11N5O4
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SMILES
O=C(NCCOC)CN1N=C([N+]([O-])=O)N=C1
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Synonyms
AK-2123
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Rajagopalan, et al. Radiosensitizer Sanazole (AK-2123) enhances γ-radiation-induced Apoptosis in murine fibrosarcoma. Journal of radiation research 44.4 (2003): 359-365. [Content Brief]
[2]. García-Angulo, et al. "Intratumoral and parametrial infusion of a 3-nitrotriazole (AK-2123) in the radiotherapy of the uterine cervix cancer: stage II–III—preliminary positive results." International Journal of Radiation Oncology Biology Physics 22.3 (1992): 589-591. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Sanazole Related Classifications
HY-117249 Related Classifications
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