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RGFP966

54 Cited Publications
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Based on 54 publication(s) in Google Scholar

RGFP966 is a highly selective HDAC3 inhibitor with an IC50 of 80 nM and shows no inhibition to other HDACs at concentrations up to 15 μM. RGFP966 can penetrate the blood brain barrier (BBB).

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  • Pureté: 99.81%
  • CAS No.: 1357389-11-7
  • Formule: C21H19FN4O
  • Masse moléculaire:362.40
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • RGFP966 Chemical Structure
    RGFP966 Chemical Structure
  • Experimental Validation Results for RGFP966
  • Experimental Validation Results for RGFP966
  • Experimental Validation Results for RGFP966
  • Experimental Validation Results for RGFP966
  • Experimental Validation Results for RGFP966
  • Experimental Validation Results for RGFP966
  • Experimental Validation Results for RGFP966
CAS No.: 1357389-11-7
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  • RGFP966 Chemical Structure
    RGFP966 Chemical Structure
    1/16
  • 1/16

    RGFP966 purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Feb 28;11(9):eadq2881. [Abstract]

    Customer Validation
     RGFP966 (10 mg/kg or 40 mg/kg; i.p.; every 2 days for 28 days) significantly increased the brain metastasis-free survival in a dose-dependent manner.

  • 1/16

    RGFP966 purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Nov 26;22(1):280. [Abstract]

    Customer Validation
     RGFP966 (1 µg/µL; i.t.; single dose) alleviated​ LDs accumulation in SDH. Scale bars: 100μm.

  • 1/16

    RGFP966 purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Nov 26;22(1):280. [Abstract]

    Customer Validation
     Level of lysine acetylation of FOXA2 in BV2 cells after treatment with vehicle (PBS) or RGFP966 (15 µM; 6 h).

  • 1/16

    RGFP966 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2021 Mar 18;19(1):35. [Abstract]

    Customer Validation
     Representative immunofluorescence with CD31 from db/m mice, db/db mice, and RGFP966 or vehicle treated (10 mg/kg; s.c.) db/db mice aorta tissue sections. The red area represented endothelium and the nucleus was blue. Scale bars: 200 μm.

  • 1/16

    RGFP966 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2020 Oct 1;80(1):43-58.e7. [Abstract]

    Customer Validation
     LPS-primed BMDMs treated with RGFP966 (2-10 μM) 30 min before ATP. SNs and cell extracts (lysate) were analyzed by immunoblotting.

  • 1/16

    RGFP966 purchased from MedChemExpress. Usage Cited in: Front Physiol. 2019 Aug 20;10:1060. [Abstract]

    Customer Validation
     Osteoarthritis rats are treated with RGFP966. Immunohistochemistry (IHC) was performed to measure relative inflammatory proteins in OA. Expression of collagen II in CG and OAG + RGFP966 group is higher than OAG by IHC.

  • 1/16

    RGFP966 purchased from MedChemExpress. Usage Cited in: Pancreatology. 2019 Mar;19(2):383-389. [Abstract]

    Customer Validation
     RGFP966 decreases PD-L1 expression in a time- and dose-dependent manner in pancreatic cancer cells.

  • RGFP966