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Cat. No.: HY-187195

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Abd141

Abd141 is a dual PROTAC degrader of ATR and Aurora kinase A (AURKA), with DC₅₀ values of 97.7 nM and 6.7 nM, respectively. Abd141 inhibits the proliferation of acute lymphoblastic leukemia cells. Abd141 can be used in the research of acute lymphoblastic leukemia.
(Pink: AURKA and ATR ligand (HY-187196); Blue: Cereblon ligand (HY-43722); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₄₃H₄₄N₈O₇S
Masse moléculaire:816.92

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Abd141 Chemical Structure

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Quantité

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
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Activité biologique

Description

Abd141 is a dual PROTAC degrader of ATR and Aurora kinase A (AURKA), with DC₅₀ values of 97.7 nM and 6.7 nM, respectively. Abd141 inhibits the proliferation of acute lymphoblastic leukemia cells. Abd141 can be used in the research of acute lymphoblastic leukemia^[1]. (Pink: AURKA and ATR ligand (HY-187196); Blue: Cereblon ligand (HY-43722); Black: linker).

IC₅₀ & Target

^[1]

Aurora A

6.7 nM (DC₅₀)

ATR

97.7 nM (DC₅₀)

Cereblon

97 nM (Kd)

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform ATM/ATR :

Voir tous les produits spécifiques à Isoform Aurora Kinase :

In Vitro

OthersAnti-cancerApoptosis

Others

Abd141 binds to CRBNmidi, with a measured K_d value of 97 nM determined by MST at 25 °C^[1].

Anti-cancer

Abd141 (10 nM-5 μM; 24 h) potently degrades ATR (DC₅₀ = 97.7 nM) and Aurora A (DC₅₀ = 6.7 nM) after 24-hour incubation in MOLT-4 acute lymphoblastic leukemia cells, and does not affect the level of WEE1 at a concentration of 500 nM^[1].
Abd141 (0.5 μM; 24-120 h) inhibits the proliferation of MOLT-4 acute lymphoblastic leukemia cells in a CRBN-dependent manner^[1].

Anti-cancer

Apoptosis

Abd141 (0.5 μM; 24 h) enhances Cytarabine (HY-13605)-induced apoptosis of MOLT-4 acute lymphoblastic leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MOLT-4 wild-type and MOLT-4ΔCRBN cells
Concentration:

0.5 μM
Incubation Time:

24 h, 96 h, 120 h
Result:

Stalled MOLT-4 wild-type cell growth, with significantly lower cell numbers at 96 h and 120 h compared to untreated controls.
Showed no growth suppression in MOLT-4ΔCRBN cells.

Apoptosis Analysis^[1]

Cell Line:

MOLT-4 cells
Concentration:

0.5 μM Abd141; 0.5 μM Cytarabine
Incubation Time:

24 h
Result:

Did not induce significant apoptosis when used alone.
Augmented Cytarabine-induced apoptosis from 34% to 62%.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

Masse moléculaire 816.92
Formule C₄₃H₄₄N₈O₇S
SMILES

O=C(C1=NC(C2=CC=C(S(=O)(NCCC3CCN(C(CCCC#CC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)=O)CC3)=O)C=C2)=CN=C1N)NC7=CC=CC=C7
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Alfayomy AM, et al. Identification of dual-targeting PROTACs for ataxia telangiectasia and RAD3-related and aurora kinase A as chemo-sensitizers for leukemia cells. European journal of medicinal chemistry. 2026 Jul 10;318:119125. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
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Abd141

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform ATM/ATR

Voir tous les produits spécifiques à Isoform Aurora Kinase

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