Azumamide E
Azumamide E is a HDAC inhibitor, with an IC50 of 0.064 μM against HDAC, 1.22 μM against HDAC1, and 2.28 μM against HDAC4. Azumamide E inhibits HDAC activity in nuclear extracts of leukemia cells and cervical adenocarcinoma cells. Azumamide E suppresses angiogenesis. Azumamide E is applicable for research on leukemia, cervical adenocarcinoma, and anti-angiogenesis.
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- CAS No.: 585535-37-1
- Formule: C27H38N4O6
- Masse moléculaire:514.62
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HDAC1 1..22 μM (IC50) |
HDAC4 2.28 μM (IC50) |
Azumamide E (Compound 5) potently inhibits HDAC activity in human leukemia K562 cells, with an IC50 of 0.064 μM[1].
Azumamide potently inhibits HDAC1 and HDAC4 enzymes prepared from 293T cells, with IC50 values of 1.22 μM and 2.28 μM, respectively, and does not inhibit HDAC6 at concentrations up to 50 μM[2].
Azumamide E (0-19 μM) exhibits dose-dependent anti-angiogenic activity in an in vitro vascular formation model using mouse induced pluripotent stem cells (iPS cells), with potent inhibitory effects observed at 1.9 μM and activity detectable at 0.19 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 585535-37-1
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Masse moléculaire 514.62
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Formule C27H38N4O6
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Sequence
Cyclo({d-Ala}-{d-Phe}-{Oaa}-{d-Val})
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Sequence Shortening
Cyclo(af-{Oaa}-v)
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Structure Classification
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Initial Source
Marine Sponge Mycale izuensis
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Nakao Y, et al. Azumamides A-E: histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis. Angew Chem Int Ed Engl. 2006 Nov 20;45(45):7553-7. [Content Brief]
[2]. Nakao Y, et al. Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008;18(9):2982-2984. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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