Balanol
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides.
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- CAS No.: 63590-19-2
- Formule: C28H26N2O10
- Masse moléculaire:550.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Human PKCα 4-9 nM () |
PKC-βI 4-9 nM () |
PKC-βII 4-9 nM () |
Human PKCγ 4-9 nM () |
Human PKCδ 4-9 nM () |
Human PKCε 4-9 nM () |
human PKCη 150 nM () |
PKA |
Balanol (3 μM; 45 min) inhibits PKA, as inhibiting the induction of luciferase activity by Isoproterenol (HY-B0468) in neonatal rat myocytes A431 cells[1].
Balanol (10 μM; 45 min) inhibits the phosphorylation of CREB and MARCKS in A431 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 63590-19-2
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Masse moléculaire 550.51
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Formule C28H26N2O10
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SMILES
O=C(C1=C(C=C(C(O[C@H]2[C@@H](CNCCC2)NC(C3=CC=C(O)C=C3)=O)=O)C=C1O)O)C4=C(C=CC=C4O)C(O)=O
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Synonyms
Ophiocordin; Azepinostatin
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Initial Source
V. balanoides
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (269 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Balanol Related Classifications
HY-121197 Related Classifications
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