HPB
Based on 1 Customer Validation
HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1.
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- Pureté: 99.11%
- CAS No.: 1800066-24-3
- Formule: C18H20N2O4
- Masse moléculaire:328.36
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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HDAC6 31 nM (IC50) |
HDAC1 1130 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
1130 nM
Compound: HPB
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Inhibition of recombinant human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in release of 7-amino-4-methoxycoumarin using fluorogenic HDAC as substrate measured after 30 mins by fluo
Inhibition of recombinant human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in release of 7-amino-4-methoxycoumarin using fluorogenic HDAC as substrate measured after 30 mins by fluo
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[PMID: 31414801] |
| Sf9 | IC50 |
31 nM
Compound: HPB
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Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells assessed as decrease in release of 7-amino-4-methoxycoumarin using fluorogenic HDAC as substrate measured after 30 mins by fluoresce
Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells assessed as decrease in release of 7-amino-4-methoxycoumarin using fluorogenic HDAC as substrate measured after 30 mins by fluoresce
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[PMID: 31414801] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1800066-24-3
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Appearance Solid
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Masse moléculaire 328.36
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Formule C18H20N2O4
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Color White to light yellow
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SMILES
O=C(N(CC1=CC=C(C(NO)=O)C=C1)CCO)CC2=CC=CC=C2
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Synonyms
HDAC6 inhibitor HPB
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (304.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
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- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0454 mL | 15.2272 mL | 30.4544 mL | 76.1360 mL |
| 5 mM | 0.6091 mL | 3.0454 mL | 6.0909 mL | 15.2272 mL | |
| 10 mM | 0.3045 mL | 1.5227 mL | 3.0454 mL | 7.6136 mL | |
| 15 mM | 0.2030 mL | 1.0151 mL | 2.0303 mL | 5.0757 mL | |
| 20 mM | 0.1523 mL | 0.7614 mL | 1.5227 mL | 3.8068 mL | |
| 25 mM | 0.1218 mL | 0.6091 mL | 1.2182 mL | 3.0454 mL | |
| 30 mM | 0.1015 mL | 0.5076 mL | 1.0151 mL | 2.5379 mL | |
| 40 mM | 0.0761 mL | 0.3807 mL | 0.7614 mL | 1.9034 mL | |
| 50 mM | 0.0609 mL | 0.3045 mL | 0.6091 mL | 1.5227 mL | |
| 60 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2689 mL | |
| 80 mM | 0.0381 mL | 0.1903 mL | 0.3807 mL | 0.9517 mL | |
| 100 mM | 0.0305 mL | 0.1523 mL | 0.3045 mL | 0.7614 mL |
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